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Aims: The presence of coronary tandem lesions poses a significant challenge for the accurate diagnosis and management of coronary artery diseases. This study set out to provide a deeper understanding of the haemodynamic interactions between…

\emph{In vitro} experiments in which tumour cells are seeded in a gelatinous medium, or hydrogel, show how mechanical interactions between tumour cells and the tissue in which they are embedded, together with local levels of an…

Tissues and Organs · Quantitative Biology 2022-06-13 Gopikrishnan C. Remesan , Jennifer A Flegg , Helen M Byrne

Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional…

Blood pressure regulation is commonly addressed in terms of local mechanisms such as vascular resistance, compliance and neurohumoral control. However, the human vasculature encompasses multiple quasi-closed flow loops under both…

Medical Physics · Physics 2026-02-11 Arturo Tozzi

The two-phase mixing layer formed between parallel gas and liquid streams is an important fundamental problem in turbulent multiphase flows. The problem is relevant to many industrial applications and natural phenomena, such as air-blast…

Fluid Dynamics · Physics 2018-12-05 Y. Ling , D. Fuster , G. Tryggvason , S. Zaleski

The coarse-grained molecular dynamics (MD) or Brownian dynamics (BD) simulation is a particle-based approach that has been applied to a wide range of biological problems that involve interactions with surrounding fluid molecules or the…

Soft Condensed Matter · Physics 2014-11-20 Szu-Pei Fu , Yuan-Nan Young , Shidong Jiang

Recent developments in surgical robotics have led to new advancements in the automation of surgical sub-tasks such as suturing, soft tissue manipulation, tissue tensioning and cutting. However, integration of dynamics to optimize these…

Robotics · Computer Science 2021-02-03 Jingbin Huang , Fei Liu , Florian Richter , Michael C. Yip

We explore the bifurcations and dynamics of a scalar differential equation with a single constant delay which models the population of human hematopoietic stem cells in the bone marrow. One parameter continuation reveals that with a delay…

Dynamical Systems · Mathematics 2021-12-03 Daniel C. De Souza , Antony R. Humphries

Parametric reduced-order modelling often serves as a surrogate method for hemodynamics simulations to improve the computational efficiency in many-query scenarios or to perform real-time simulations. However, the snapshots of the method…

Computational Engineering, Finance, and Science · Computer Science 2023-10-24 Dongwei Ye , Valeria Krzhizhanovskaya , Alfons G. Hoekstra

Understanding how red blood cell (RBC) suspensions navigate porous materials is critical for for both fundamental physiology, such as maternal-fetal exchange in the placenta, and transformative biomedical applications, including rapid,…

Soft Condensed Matter · Physics 2025-09-03 Sampad Laha , Ananta Kumar Nayak , Alexander Farutin , Suman Chakraborty , Chaouqi Misbah

In this paper, a novel deep learning framework is proposed for temporal super-resolution simulation of blood vessel flows, in which a high-temporal-resolution time-varying blood vessel flow simulation is generated from a…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Zhizheng Jiang , Fei Gao , Renshu Gu , Jinlan Xu , Gang Xu , Timon Rabczuk

We consider a mathematical model for the evolutionary dynamics of tumour cells in vascularised tumours under chemotherapy. The model comprises a system of coupled partial integro-differential equations for the phenotypic distribution of…

Tissues and Organs · Quantitative Biology 2020-06-02 Chiara Villa , Mark A. J. Chaplain , Tommaso Lorenzi

The dynamical mechanical analysis of blood generally uses models inspired by conventional flows, assuming scale-independent homogeneous flows and without considering fluid-surface boundary interactions. The present experimental study…

Fluid Dynamics · Physics 2024-09-24 Ursula Windberger , Patrick Baroni , Laurence Noirez

Non-particulate continuum descriptions allow for computationally efficient modeling of suspension flows at scales that are inaccessible to more detailed particulate approaches. It is well known that the presence of particles influences the…

Soft Condensed Matter · Physics 2013-11-13 Florian Janoschek , Jens Harting , Federico Toschi

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

The dynamics of red blood cells (RBCs) in oscillatory shear flow was studied using differential equations of three variables: a shape parameter, the inclination angle $\theta$, and phase angle $\phi$ of the membrane rotation. In steady…

Soft Condensed Matter · Physics 2010-06-24 Hiroshi Noguchi

Phase-field models have proven indispensable for deciphering the microstructure complexities inherent in multicomponent systems. The confluence of varying phase molar volumes presents unique challenges. Understanding the impact of molar…

Materials Science · Physics 2025-03-25 Chengyin Wu , Yanzhou Ji

Bifurcations and branches in the microcirculation dramatically affect blood flow as they determine the spatiotemporal organization of red blood cells (RBCs). Such changes in vessel geometries can further influence the formation of a…

In this study, we present a comprehensive numerical analysis of blood flow within human left ventricle models, with particular emphasis on optimizing simulation conditions to enhance the realism and computational efficiency of heart flow…

Various biological processes such as transport of oxygen and nutrients, thrombus formation, vascular angiogenesis and remodeling are related to cellular/subcellular level biological processes, where mesoscopic simulations resolving detailed…

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