Related papers: Predicting erectile dysfunction after treatment fo…
Modern external beam cancer radiotherapy applies prescribed radiation doses to tumor targets while minimally affecting nearby vulnerable organs-at-risk (OARs). Creating a treatment plan is difficult and time-consuming with no guarantee of…
Studies have identified various risk factors associated with the onset of stroke in an individual. Data mining techniques have been used to predict the occurrence of stroke based on these factors by using patients' medical records. However,…
This work aims to study the generalizability of a pre-developed deep learning (DL) dose prediction model for volumetric modulated arc therapy (VMAT) for prostate cancer and to adapt the model to three different internal treatment planning…
Colorectal cancer refers to the cancer from the dentate line to the junction of rectosigmoid colon, which is one of the most common malignant tumors of the digestive tract. The treatment of colorectal cancer is controversial, so…
Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy, yet voxel-wise DL uncertainty maps are rarely presented to clinicians. Purpose: This study assessed how DL-generated uncertainty maps impact…
Diabetes mellitus is a common disease of human body caused by a group of metabolic disorders where the sugar levels over a prolonged period is very high. It affects different organs of the human body which thus harm a large number of the…
Distinguishing causal relationships from statistical correlations remains a fundamental challenge in clinical research, limiting the translation of observational findings into interventional treatment guidelines. Here we apply causal…
Overtreatment of early-stage low-risk prostate cancer (PC) patients represents a significant problem in disease management and has socio-economic implications. Development of genetic and molecular markers of clinically significant disease…
As the global population ages, the incidence of Chronic Kidney Disease (CKD) is rising. CKD often remains asymptomatic until advanced stages, which significantly burdens both the healthcare system and patient quality of life. This research…
The nature of clinical data makes it difficult to quickly select, tune and apply machine learning algorithms to clinical prognosis. As a result, a lot of time is spent searching for the most appropriate machine learning algorithms…
Over 30 million Americans are affected by Type II diabetes (T2D), a treatable condition with significant health risks. This study aims to develop and validate predictive models using machine learning (ML) techniques to estimate emergency…
Prostate cancer is one of the most frequently diagnosed malignancies in men worldwide. However, precise prediction of biochemical recurrence (BCR) after radical prostatectomy remains challenging due to the multifocality of tumors…
The performance of Emergency Departments (EDs) is of great importance for any health care system, as they serve as the entry point for many patients. However, among other factors, the variability of patient acuity levels and corresponding…
Almost 30% of prostate cancer (PCa) patients undergoing radical prostatectomy (RP) experience biochemical recurrence (BCR), characterized by increased prostate specific antigen (PSA) and associated with increased mortality. Accurate early…
Lung cancer is a significant cause of mortality worldwide, emphasizing the importance of early detection for improved survival rates. In this study, we propose a machine learning (ML) tool trained on data from the PLCO Cancer Screening…
Biparametric MRI has emerged as an alternative to multiparametric prostate MRI, which eliminates the need for the potential harms to the patient due to the contrast medium. One major issue with biparametric MRI is difficulty to detect…
Globally, infertility rates are increasing, with 2.5\% of all births being assisted by in vitro fertilisation (IVF) in 2022. Male infertility is the cause for approximately half of these cases. The quality of sperm DNA has substantial…
As cancer advances, cells often spread from the primary tumor to other parts of the body and form metastases. This is the main cause of cancer related mortality. Here we investigate a conceptually simple model of metastasis formation where…
In cancer epidemiology using population-based data, regression models for the excess mortality hazard is a useful method to estimate cancer survival and to describe the association between prognosis factors and excess mortality. This method…
Nowadays, Breast cancer has risen to become one of the most prominent causes of death in recent years. Among all malignancies, this is the most frequent and the major cause of death for women globally. Manually diagnosing this disease…