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We target the problem of provably computing the equivalence between two complex expression trees. To this end, we formalize the problem of equivalence between two such programs as finding a set of semantics-preserving rewrite rules from one…

Programming Languages · Computer Science 2021-06-10 Steve Kommrusch , Théo Barollet , Louis-Noël Pouchet

Molecular evolution is the process of simulating the natural evolution of molecules in chemical space to explore potential molecular structures and properties. The relationships between similar molecules are often described through…

Biomolecules · Quantitative Biology 2025-01-28 Kun Li , Longtao Hu , Xiantao Cai , Jia Wu , Wenbin Hu

Genome-Scale Metabolic Models (GEMs) describe the interactions between genes, proteins, and the biochemical reactions that underpin an organism's metabolism aiming to computationally simulate functions at the cellular level. While many…

This paper surveys the trend of leveraging machine learning to solve mixed integer programming (MIP) problems. Theoretically, MIP is an NP-hard problem, and most of the combinatorial optimization (CO) problems can be formulated as the MIP.…

Artificial Intelligence · Computer Science 2022-03-08 Jiayi Zhang , Chang Liu , Junchi Yan , Xijun Li , Hui-Ling Zhen , Mingxuan Yuan

A gene expression compendium is a heterogeneous collection of gene expression experiments assembled from data collected for diverse purposes. The widely varied experimental conditions and genetic backgrounds across samples creates a…

Quantitative Methods · Quantitative Biology 2022-03-29 Alexandra J. Lee , Taylor Reiter , Georgia Doing , Julia Oh , Deborah A. Hogan , Casey S. Greene

Ongoing progress in computational intelligence (CI) has led to an increased desire to apply CI techniques for the purpose of improving software engineering processes, particularly software testing. Existing state-of-the-art automated…

Neural and Evolutionary Computing · Computer Science 2023-02-16 Jarrod Goschen , Anna Sergeevna Bosman , Stefan Gruner

Machine learning components commonly appear in larger decision-making pipelines; however, the model training process typically focuses only on a loss that measures accuracy between predicted values and ground truth values. Decision-focused…

Machine Learning · Computer Science 2019-07-19 Aaron Ferber , Bryan Wilder , Bistra Dilkina , Milind Tambe

Representation Engineering (RepE) is a novel paradigm for controlling the behavior of LLMs. Unlike traditional approaches that modify inputs or fine-tune the model, RepE directly manipulates the model's internal representations. As a…

Machine Learning · Computer Science 2025-10-09 Jan Wehner , Sahar Abdelnabi , Daniel Tan , David Krueger , Mario Fritz

The single nucleotide polymorphism (SNP) is the most widely studied type of genetic variation. A haplotype is defined as the sequence of alleles at SNP sites on each haploid chromosome. Haplotype information is essential in unravelling the…

Genomics · Quantitative Biology 2020-06-19 Sina Majidian , Mohammad Hossein Kahaei , Dick de Ridder

We present a new combinatorial model for identifying regulatory modules in gene co-expression data using a decomposition into weighted cliques. To capture complex interaction effects, we generalize the previously-studied weighted edge…

Data Structures and Algorithms · Computer Science 2021-09-08 Madison Cooley , Casey S. Greene , Davis Issac , Milton Pividori , Blair D. Sullivan

Genetic Programming (GP) has traditionally entangled the evolution of symbolic representations with their performance-based evaluation, often relying solely on raw fitness scores. This tight coupling makes GP solutions more fragile and…

Neural and Evolutionary Computing · Computer Science 2025-06-09 Nam H. Le , Josh Bongard

This paper examines the Evolutionary programming (EP) method for optimizing PID parameters. PID is the most common type of regulator within control theory, partly because it's relatively simple and yields stable results for most…

Neural and Evolutionary Computing · Computer Science 2017-09-28 Adam Nyberg

Multiword expressions (MWEs) are composed of multiple words and exhibit variable degrees of compositionality. As such, their meanings are notoriously difficult to model, and it is unclear to what extent this issue affects transformer…

Computation and Language · Computer Science 2024-01-30 Filip Miletić , Sabine Schulte im Walde

The objective of this paper is to define an effective strategy for building an ensemble of Genetic Programming (GP) models. Ensemble methods are widely used in machine learning due to their features: they average out biases, they reduce the…

Neural and Evolutionary Computing · Computer Science 2019-06-14 Mauro Castelli , Ivo Gonçalves , Luca Manzoni , Leonardo Vanneschi

Despite LLMs' excellent code creation capabilities, multilingual code generation remains extremely challenging. To address this, we intent to improve the multi-programming-lingual (MultiPL) performance of the base LLMs while retaining the…

Computation and Language · Computer Science 2025-09-09 Qing Wang , Xue Han , Jiahui Wang , Lehao Xing , Qian Hu , Lianlian Zhang , Chao Deng , Junlan Feng

The application of genetic algorithms (GAs) to many optimization problems in organizations often results in good performance and high quality solutions. For successful and efficient use of GAs, it is not enough to simply apply simple GAs…

Neural and Evolutionary Computing · Computer Science 2008-12-18 Maroun Bercachi , Philippe Collard , Manuel Clergue , Sébastien Verel

Deep learning, a rebranding of deep neural network research works, has achieved a remarkable success in recent years. With multiple hidden layers, deep learning models aim at computing the hierarchical feature representations of the…

Neural and Evolutionary Computing · Computer Science 2018-06-06 Jiawei Zhang , Limeng Cui , Fisher B. Gouza

Standard multiparameter eigenvalue problems (MEPs) are systems of $k\ge 2$ linear $k$-parameter square matrix pencils. Recently, a new form of multiparameter eigenvalue problems has emerged: a rectangular MEP (RMEP) with only one…

Numerical Analysis · Mathematics 2023-12-19 Michiel E. Hochstenbach , Tomaž Košir , Bor Plestenjak

In biological research machine learning algorithms are part of nearly every analytical process. They are used to identify new insights into biological phenomena, interpret data, provide molecular diagnosis for diseases and develop…

Feature selection is a crucial step in data mining to enhance model performance by reducing data dimensionality. However, the increasing dimensionality of collected data exacerbates the challenge known as the "curse of dimensionality",…

Machine Learning · Computer Science 2024-02-15 Xubin Wang , Haojiong Shangguan , Fengyi Huang , Shangrui Wu , Weijia Jia