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The idea of using fragment embedding to circumvent the high computational scaling of accurate electronic structure methods while retaining high accuracy has been a long-standing goal for quantum chemists. Traditional fragment embedding…

Chemical Physics · Physics 2022-10-11 Hong-Zhou Ye , Matthew Welborn , Nathan D. Ricke , Troy Van Voorhis

Atomistic simulation methods have evolved through successive computational levels, each building upon more fundamental approaches: from quantum mechanics to density functional theory (DFT), and subsequently, to machine learning interatomic…

The expectation-maximization (EM) algorithm is a well-known iterative method for computing maximum likelihood estimates from incomplete data. Despite its numerous advantages, a main drawback of the EM algorithm is its frequently observed…

Computation · Statistics 2018-08-14 Nicholas C. Henderson , Ravi Varadhan

The family of Expectation-Maximization (EM) algorithms provides a general approach to fitting flexible models for large and complex data. The expectation (E) step of EM-type algorithms is time-consuming in massive data applications because…

Computation · Statistics 2018-06-21 Sanvesh Srivastava , Glen DePalma , Chuanhai Liu

This fluid dynamics video showcases how optically induced electrowetting can be used to manipulate liquid droplets in open space and particulate phases inside the droplet. A photoconductive layer is added to a conventional…

Fluid Dynamics · Physics 2009-10-20 Han-Sheng Chuang , Aloke Kumar , Steven T. Wereley

This review describes recent advances by the authors and others on the topic of incorporating experimental data into molecular simulations through maximum entropy methods. Methods which incorporate experimental data improve accuracy in…

Chemical Physics · Physics 2019-05-15 Dilnoza B. Amirkulova , Andrew D. White

Determinantal Point Processes (DPPs) are elegant probabilistic models of repulsion and diversity over discrete sets of items. But their applicability to large sets is hindered by expensive cubic-complexity matrix operations for basic tasks…

Machine Learning · Computer Science 2016-05-31 Chengtao Li , Stefanie Jegelka , Suvrit Sra

It was recently demonstrated that a simple Monte Carlo (MC) algorithm involving the swap of particle pairs dramatically accelerates the equilibrium sampling of simulated supercooled liquids. We propose two numerical schemes integrating the…

Statistical Mechanics · Physics 2019-06-24 Ludovic Berthier , Elijah Flenner , Christopher J. Fullerton , Camille Scalliet , Murari Singh

To prepare images for better segmentation, we need preprocessing applications, such as smoothing, to reduce noise. In this paper, we present an enhanced computation method for smoothing 2D object in binary case. Unlike existing approaches,…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-03-31 Ramzi Mahmoudi , Mohamed Akil

We propose a novel semiparametric model for the joint distribution of a continuous longitudinal outcome and the baseline covariates using an enriched Dirichlet process (EDP) prior. This joint model decomposes into a linear mixed model for…

Methodology · Statistics 2018-06-08 Bret Zeldow , James Flory , Alisa Stephens-Shields , Marsha Raebel , Jason Roy

In this paper, we studied a buffered mini-batch gradient descent (BMGD) algorithm for training complex model on massive datasets. The algorithm studied here is designed for fast training on a GPU-CPU system, which contains two steps: the…

Computation · Statistics 2023-12-15 Haobo Qi , Du Huang , Yingqiu Zhu , Danyang Huang , Hansheng Wang

Distribution Matching Distillation (DMD) distills score-based generative models into efficient one-step generators, without requiring a one-to-one correspondence with the sampling trajectories of their teachers. Yet, the limited capacity of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Xiangyu Fan , Zesong Qiu , Zhuguanyu Wu , Fanzhou Wang , Zhiqian Lin , Tianxiang Ren , Dahua Lin , Ruihao Gong , Lei Yang

Flow-based microfluidic biochips have attracted much atten- tion in the EDA community due to their miniaturized size and execution efficiency. Previous research, however, still follows the traditional computing model with a dedicated…

Emerging Technologies · Computer Science 2017-05-16 Chunfeng Liu , Bing Li , Hailong Yao , Paul Pop , Tsung-Yi Ho , Ulf Schlichtmann

Large-scale atomistic simulations are essential to bridge computational materials and chemistry to realistic materials and drug discovery applications. In the past few years, rapid developments of machine learning interatomic potentials…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-03 Kevin Han , Bowen Deng , Amir Barati Farimani , Gerbrand Ceder

The goal of entanglement distillation is to turn a large number of weakly entangled states into a smaller number of highly entangled ones. Practical entanglement distillation schemes offer a tradeoff between the fidelity to the target…

Molecule optimization is a critical step in drug development to improve desired properties of drug candidates through chemical modification. We developed a novel deep generative model Modof over molecular graphs for molecule optimization.…

Machine Learning · Computer Science 2022-01-17 Ziqi Chen , Martin Renqiang Min , Srinivasan Parthasarathy , Xia Ning

Finite mixture models are powerful tools for modelling and analyzing heterogeneous data. Parameter estimation is typically carried out using maximum likelihood estimation via the Expectation-Maximization (EM) algorithm. Recently, the…

Computation · Statistics 2020-05-15 Sharon X. Lee , Geoffrey J. McLachlan , Kaleb L. Leemaqz

With the emergence of various molecular tasks and massive datasets, how to perform efficient training has become an urgent yet under-explored issue in the area. Data pruning (DP), as an oft-stated approach to saving training burdens,…

Machine Learning · Computer Science 2024-09-04 Dingshuo Chen , Zhixun Li , Yuyan Ni , Guibin Zhang , Ding Wang , Qiang Liu , Shu Wu , Jeffrey Xu Yu , Liang Wang

Biocomputing systems based on engineered bacteria can lead to novel tools for environmental monitoring and detection of metabolic diseases. In this paper, we propose a Bacterial Molecular Computing on a Chip (BMCoC) using microfluidic and…

Numerical simulation of the complex plasma dynamics associated with high power, high frequency microwave breakdown at high pressures, leading to the formation of filamentary plasma structures such as self-organized plasma arrays, is a…

Plasma Physics · Physics 2025-05-13 Pratik Ghosh , Bhaskar Chaudhury