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Network inference, the task of reconstructing interactions in a complex system from experimental observables, is a central yet extremely challenging problem in systems biology. While much progress has been made in the last two decades,…

Quantitative Methods · Quantitative Biology 2024-09-12 Stephen Y Zhang

Most stroke patients experience upper limb motor dysfunction. Compensatory movements are prevalent during rehabilitation training, which is detrimental to patients' long-term recovery. Therefore, detecting compensatory movements is of great…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Jiaxing Fan , Jiaojiao Liu , Wenkong Wang , Yang Zhang , Xin Ma , Jichen Zhang

Deep neural networks (DNN) have shown promises in the lesion segmentation of multiple sclerosis (MS) from multicontrast MRI including T1, T2, proton density (PD) and FLAIR sequences. However, one challenge in deploying such networks into…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Yushan Feng , Huitong Pan , Craig Meyer , Xue Feng

Understanding brain dynamics and functions critically depends on knowledge of the network connectivity among neurons. However, the complexity of brain structural connectivity, coupled with continuous modifications driven by synaptic…

Neurons and Cognition · Quantitative Biology 2025-07-04 Kai Chen , Mingzhang Wang , Songting Li , Douglas Zhou

Electronic Health Records (EHRs) provide high-dimensional temporal data essential for patient modeling; however, conventional algorithmic approaches often rely on data aggregation or imputation, which distorts temporal disease trajectories.…

Machine Learning · Computer Science 2026-04-21 Pi-Ju Tsai , Charkkri Limbud , Kuan-Fu Chen , Yi-Ju Tseng

Current deep learning-based approaches to lesion segmentation in neuroimaging often depend on high-resolution images and extensive annotated data, limiting clinical applicability. This paper introduces a novel synthetic data framework…

Image and Video Processing · Electrical Eng. & Systems 2025-08-18 Liam Chalcroft , Ioannis Pappas , Cathy J. Price , John Ashburner

Stroke is one of the main causes of human disabilities. Experimental observations indicate that several mechanisms are activated during the recovery of functional activity after a stroke. Here we unveil how the brain recovers by explaining…

Neurons and Cognition · Quantitative Biology 2019-11-19 Damian Berger , Emanuele Varriale , Laurens Michiels van Kessenich , Hans J. Herrmann , Lucilla de Arcangelis

The trajectory on the road traffic is commonly collected at a low sampling rate, and trajectory recovery aims to recover a complete and continuous trajectory from the sparse and discrete inputs. Recently, sequential language models have…

Machine Learning · Computer Science 2023-11-07 Dedong Li , Ziyue Li , Zhishuai Li , Lei Bai , Qingyuan Gong , Lijun Sun , Wolfgang Ketter , Rui Zhao

Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute…

Quantitative Methods · Quantitative Biology 2019-03-28 Eryu Xia , Xin Du , Jing Mei , Wen Sun , Suijun Tong , Zhiqing Kang , Jian Sheng , Jian Li , Changsheng Ma , Jianzeng Dong , Shaochun Li

Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Mehdi Hosseini Chagahi , Saeed Mohammadi Dashtaki , Niloufar Delfan , Nadia Mohammadi , Farshid Rostami Pouria , Behzad Moshiri , Md. Jalil Piran , Oliver Faust

Stroke segmentation plays a crucial role in the diagnosis and treatment of stroke patients by providing spatial information about affected brain regions and the extent of damage. Segmenting stroke lesions accurately is a challenging task,…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Yalda Zafari-Ghadim , Ahmed Soliman , Yousif Yousif , Ahmed Ibrahim , Essam A. Rashed , Mohamed Mabrok

Understanding the longitudinally changing associations between Social Determinants of Health (SDOH) and stroke mortality is essential for effective stroke management. Previous studies have uncovered significant regional disparities in the…

Methodology · Statistics 2025-02-04 Fangzhi Luo , Jianbin Tan , Donglan Zhang , Hui Huang , Ye Shen

Existing tracking methods mainly focus on learning better target representation or developing more robust prediction models to improve tracking performance. While tracking performance has significantly improved, the target loss issue occurs…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 Yuqing Huang , Xin Li , Zikun Zhou , Yaowei Wang , Zhenyu He , Ming-Hsuan Yang

Segmenting stroke lesions from T1-weighted MR images is of great value for large-scale stroke rehabilitation neuroimaging analyses. Nevertheless, there are great challenges with this task, such as large range of stroke lesion scales and the…

Image and Video Processing · Electrical Eng. & Systems 2021-02-17 Hao Yang , Weijian Huang , Kehan Qi , Cheng Li , Xinfeng Liu , Meiyun Wang , Hairong Zheng , Shanshan Wang

Stroke classification remains challenging due to variations in writing style, ambiguous content, and dynamic writing positions. The core challenge in stroke classification is modeling the semantic relationships between strokes. Our…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Yiheng Huang , Shuang She , Zewei Wei , Jianmin Lin , Ming Yang , Wenyin Liu

The disease trajectory for clinical sepsis, in terms of temporal cytokine and phenotypic dynamics, can be interpreted as a random dynamical system. The ability to make accurate predictions about patient state from clinical measurements has…

Quantitative Methods · Quantitative Biology 2020-07-30 Dale Larie , Gary An , Chase Cockrell

The process of manually searching for relevant instances in, and extracting information from, clinical databases underpin a multitude of clinical tasks. Such tasks include disease diagnosis, clinical trial recruitment, and continuing…

Signal Processing · Electrical Eng. & Systems 2021-10-05 Dani Kiyasseh , Tingting Zhu , David A. Clifton

The representation of the flow of information between neurons in the brain based on their activity is termed the causal functional connectome. Such representation incorporates the dynamic nature of neuronal activity and causal interactions…

Neurons and Cognition · Quantitative Biology 2022-11-16 Rahul Biswas , Eli Shlizerman

We present a fully convolutional neural network for segmenting ischemic stroke lesions in CT perfusion images for the ISLES 2018 challenge. Treatment of stroke is time sensitive and current standards for lesion identification require manual…

Computer Vision and Pattern Recognition · Computer Science 2018-11-06 S. Mazdak Abulnaga , Jonathan Rubin

Autonomous robotic systems require advanced control frameworks to achieve complex temporal objectives that extend beyond conventional stability and trajectory tracking. Signal Temporal Logic (STL) provides a formal framework for specifying…

Systems and Control · Electrical Eng. & Systems 2025-04-29 Kazunobu Serizawa , Kazumune Hashimoto , Wataru Hashimoto , Masako Kishida , Shigemasa Takai