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A new technique is introduced to reconstruct a nonlinear stochastic model of the cardiorespiratory interaction. Its inferential framework uses a set of polynomial basis functions representing the nonlinear force governing the system…

Data Analysis, Statistics and Probability · Physics 2009-11-11 V. N. Smelyanskiy , D. G. Luchinsky , A. Stefanovska , P. V. E. McClintock

Recent developments in cardiovascular modelling allow us to simulate blood flow in an entire human body. Such model can also be used to create databases of virtual subjects, with sizes limited only by computational resources. In this work,…

Medical Physics · Physics 2020-07-01 Janne M. J. Huttunen , Leo Kärkkäinen , Harri Lindholm

We have advanced a point-process based framework for the regulation of heart beats by the autonomous nervous system and analyzed the model with and without feedback. The model without feedback was found amenable to several analytical…

Quantitative Methods · Quantitative Biology 2019-04-18 Bosco Emmanuel

Purpose: Conventional robotic ultrasound systems were utilized with patients in supine positions. Meanwhile, the limitation of the systems is that it is difficult to evacuate the patients in case of emergency (e.g., patient discomfort and…

Robotics · Computer Science 2022-10-26 Yuuki Shida , Masami Sugawara , Ryosuke Tsumura , Haruaki Chiba , Tokuhisa Uejima , Hiroyasu Iwata

A theoretical analysis of the mechanisms underlying the dynamics of gallbladder and heart pulsation could clarify the question regarding the classification as chaotic of the associated behaviour, eventually related to a normal and healthy…

Tissues and Organs · Quantitative Biology 2009-11-10 Giovanni Imponente

Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) $>$ 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of…

Quantitative Methods · Quantitative Biology 2025-06-06 Amanda L. Colunga , Mitchel J. Colebank , REU Program , Mette S. Olufsen

Recent research is revealing how cognitive processes are supported by a complex interplay between the brain and the rest of the body, which can be investigated by the analysis of physiological features such as breathing rhythms, heart rate,…

Quantitative Methods · Quantitative Biology 2023-03-10 Fernando E. Rosas , Diego Candia-Rivera , Andrea I Luppi , Yike Guo , Pedro A. M. Mediano

Arterial Blood Pressure wave monitoring is considered to be important in assessment of cardiovascular system. We developed a novel pulse wave detection system using low frequency specific piezoelectric material as pressure wave sensor. The…

Medical Physics · Physics 2007-05-23 Shantanu Sur , S. K. Ghatak

Patient subtyping based on temporal observations can lead to significantly nuanced subtyping that acknowledges the dynamic characteristics of diseases. Existing methods for subtyping trajectories treat the evolution of clinical observations…

Machine Learning · Computer Science 2018-11-30 Nikhil Galagali , Minnan Xu-Wilson

Cardiac action potential models allow examination of a variety of cardiac dynamics, including how behavior may change under specific interventions. To study a specific scenario, including patient-specific cases, model parameter sets must be…

Computational Engineering, Finance, and Science · Computer Science 2025-04-21 Darby I. Cairns , Maxfield R. Comstock , Flavio H. Fenton , Elizabeth M. Cherry

Traditional echocardiographic parameters such as ejection fraction (EF) and global longitudinal strain (GLS) have limitations in the early detection of cardiac dysfunction. EF often remains normal despite underlying pathology, and GLS is…

Machine Learning · Computer Science 2025-07-21 Beka Begiashvili , Carlos J. Fernandez-Candel , Matías Pérez Paredes

The low-frequency modal and non-modal stability characteristics of an incompressible, pressure-gradient-induced turbulent separation bubble (TSB) are investigated with the objective of studying the mechanism responsible for the…

Fluid Dynamics · Physics 2024-11-20 C. Cura , A. Hanifi , A. V. G. Cavalieri , J. Weiss

Objective: we propose a procedure for calibrating 4 parameters governing the mechanical boundary conditions (BCs) of a thoracic aorta (TA) model derived from one patient with ascending aortic aneurysm. The BCs reproduce the visco-elastic…

Signal-based early detection of illnesses has been a key topic in research and hospital settings; it reduces technological costs and paves the way for quick and effective patient-care operations. Elementary machine learning and signal…

Other Quantitative Biology · Quantitative Biology 2020-11-04 Camille Dunning

Photolethysmographic imaging (PPGI) is a widefield non-contact biophotonic technology able to remotely monitor cardiovascular function over anatomical areas. Though spatial context can provide increased physiological insight, existing PPGI…

Quantitative Methods · Quantitative Biology 2016-12-21 Robert Amelard , David A Clausi , Alexander Wong

Goal: Although photoplethysmogram (PPG) and electrocardiogram (ECG) signals can be used to estimate blood pressure (BP) by extracting various features, the changes in morphological contours of both PPG and ECG signals due to various…

Signal Processing · Electrical Eng. & Systems 2018-11-07 Md. Sayed Tanveer , Md. Kamrul Hasan

Atrial fibrillation (AF) increases the risk of stroke by a factor of four to five and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals…

Tissues and Organs · Quantitative Biology 2016-10-12 Kishan A. Manani , Kim Christensen , Nicholas S. Peters

Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…

Quantitative Methods · Quantitative Biology 2020-02-21 Megan J. Chambers , Mitchel J. Colebank , M Umar Qureshi , Rachel Clipp , Mette S. Olufsen

Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite…

Tissues and Organs · Quantitative Biology 2015-06-15 Klas H. Pettersen , Scott M. Bugenhagen , Javaid Nauman , Daniel A. Beard , Stig W. Omholt

The frequency response function (FRF) is an established way to describe the outcome of experiments in posture control literature. The FRF is an empirical transfer function between an input stimulus and the induced body segment sway profile,…

Applications · Statistics 2025-05-27 Vittorio Lippi