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Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

Interpretable insights from predictive models remain critical in bio-statistics, particularly when assessing causality, where classical statistical and machine learning methods often provide inherent clarity. While Neural Networks (NNs)…

Applications · Statistics 2025-05-02 Jean-Baptiste A. Conan

Summary: The DynaSig-ML (Dynamical Signatures - Machine Learning) Python package allows the efficient, user-friendly exploration of 3D dynamics-function relationships in biomolecules, using datasets of experimental measures from large…

Biomolecules · Quantitative Biology 2022-07-08 Olivier Mailhot , Francois Major , Rafael Najmanovich

In biological research machine learning algorithms are part of nearly every analytical process. They are used to identify new insights into biological phenomena, interpret data, provide molecular diagnosis for diseases and develop…

described by multiple instances (e.g., image patches) and simultaneously associated with multiple labels. Existing MIML methods are useful in many applications but most of which suffer from relatively low accuracy and training efficiency…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Qi Lai , Jianhang Zhou , Yanfen Gan , Chi-Man Vong , Deshuang Huang

Discovery of novel protein biomarkers for clinical applications is an active research field across a manifold of diseases. Despite some successes and progress, the biomarker development pipeline still frequently ends in failure as biomarker…

Biomolecules · Quantitative Biology 2025-05-01 Katharina Waury

BioImageLoader (BIL) is a python library that handles bioimage datasets for machine learning applications, easing simple workflows and enabling complex ones. BIL attempts to wrap the numerous and varied bioimages datasets in unified…

Quantitative Methods · Quantitative Biology 2023-03-07 Seongbin Lim , Xingjian Zhang , Emmanuel Beaurepaire , Anatole Chessel

This paper introduces a novel toolbox named BIDEAL for the generation of biclusters, their analysis, visualization, and validation. The objective is to facilitate researchers to use forefront biclustering algorithms embedded on a single…

Other Computer Science · Computer Science 2020-07-29 Nishchal K. Verma , T. Sharma , S. Dixit , P. Agrawal , S. Sengupta , V. Singh

The Classification of medical images and illustrations in the literature aims to label a medical image according to the modality it was produced or label an illustration according to its production attributes. It is an essential and…

Computer Vision and Pattern Recognition · Computer Science 2017-06-29 Jianpeng Zhang , Yong Xia , Qi Wu , Yutong Xie

The adoption of Deep Learning algorithms in the medical imaging field is a prominent area of research, with high potential for advancing AI-based Computer-aided diagnosis (AI-CAD) solutions. However, current solutions face challenges due to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-30 Iury B. de A. Santos , André C. P. L. F. de Carvalho

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Effective biosecurity practices in swine production are key in preventing the introduction and dissemination of infectious pathogens. Ideally, biosecurity practices should be chosen by their impact on bio-containment and bio-exclusion,…

Deep neural networks and other sophisticated machine learning models are widely applied to biomedical signal data because they can detect complex patterns and compute accurate predictions. However, the difficulty of interpreting such models…

Signal Processing · Electrical Eng. & Systems 2021-07-12 Charmaine Chia , Matteo Sesia , Chi-Sing Ho , Stefanie S. Jeffrey , Jennifer Dionne , Emmanuel J. Candès , Roger T. Howe

Motivation: Prediction of phenotypes from high-dimensional data is a crucial task in precision biology and medicine. Many technologies employ genomic biomarkers to characterize phenotypes. However, such elements are not sufficient to…

Molecular Networks · Quantitative Biology 2016-09-16 Salvatore Alaimo , Rosalba Giugno , Mario Acunzo , Dario Veneziano , Alfredo Ferro , Alfredo Pulvirenti

Antibiotics are a vital class of drugs closely associated with the prevention and treatment of bacterial infections. Accurate prediction of molecular antimicrobial activity remains a key challenge in the pursuit of novel antibiotic…

Quantitative Methods · Quantitative Biology 2025-09-23 R. He

We propose DeepMiner, a framework to discover interpretable representations in deep neural networks and to build explanations for medical predictions. By probing convolutional neural networks (CNNs) trained to classify cancer in mammograms,…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Jimmy Wu , Bolei Zhou , Diondra Peck , Scott Hsieh , Vandana Dialani , Lester Mackey , Genevieve Patterson

We introduce a new dataset, MELINDA, for Multimodal biomEdicaL experImeNt methoD clAssification. The dataset is collected in a fully automated distant supervision manner, where the labels are obtained from an existing curated database, and…

Computation and Language · Computer Science 2020-12-18 Te-Lin Wu , Shikhar Singh , Sayan Paul , Gully Burns , Nanyun Peng

Motivation: A major challenge in the development of machine learning based methods in computational biology is that data may not be accurately labeled due to the time and resources required for experimentally annotating properties of…

Machine Learning · Computer Science 2017-11-15 Amina Asif , Wajid Arshad Abbasi , Farzeen Munir , Asa Ben-Hur , Fayyaz ul Amir Afsar Minhas

Our paper introduces a robust framework for the automated identification of diseases in plant leaf images. The framework incorporates several key stages to enhance disease recognition accuracy. In the pre-processing phase, a thumbnail…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Abhishek Sebastian , Annis Fathima A , Pragna R , Madhan Kumar S , Yaswanth Kannan G , Vinay Murali

Machine learning (ML) offers a collection of powerful approaches for detecting and modeling associations, often applied to data having a large number of features and/or complex associations. Currently, there are many tools to facilitate…