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Objective: The growing availability of large-scale observational clinical datasets and challenges in conducting randomized controlled trials have spurred enthusiasm in using causal machine learning (ML) for causal inference in observational…

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

The rapid finding of effective therapeutics requires the efficient use of available resources in clinical trials. The use of covariate adjustment can yield statistical estimates with improved precision, resulting in a reduction in the…

Methodology · Statistics 2021-09-10 Nicholas Williams , Michael Rosenblum , Iván Díaz

In many predictive decision-making scenarios, such as credit scoring and academic testing, a decision-maker must construct a model that accounts for agents' propensity to "game" the decision rule by changing their features so as to receive…

Machine Learning · Computer Science 2022-08-26 Yonadav Shavit , Benjamin Edelman , Brian Axelrod

In the sequential decision making setting, an agent aims to achieve systematic generalization over a large, possibly infinite, set of environments. Such environments are modeled as discrete Markov decision processes with both states and…

Machine Learning · Computer Science 2023-03-31 Mirco Mutti , Riccardo De Santi , Emanuele Rossi , Juan Felipe Calderon , Michael Bronstein , Marcello Restelli

Causal machine learning (ML) algorithms recover graphical structures that tell us something about cause-and-effect relationships. The causal representation praovided by these algorithms enables transparency and explainability, which is…

Identifying covariates that modify treatment effects is a central problem in causal inference. Yet existing data-adaptive procedures do not provide finite-sample control over the expected number of false discoveries, risking spurious…

Methodology · Statistics 2026-05-12 Falco J. Bargagli-Stoffi , Omar Melikechi

Knowing the effect of an intervention is critical for human decision-making, but current approaches for causal effect estimation rely on manual data collection and structuring, regardless of the causal assumptions. This increases both the…

Machine Learning · Computer Science 2024-10-29 Nikita Dhawan , Leonardo Cotta , Karen Ullrich , Rahul G. Krishnan , Chris J. Maddison

We introduce COCO, an open source platform for Comparing Continuous Optimizers in a black-box setting. COCO aims at automatizing the tedious and repetitive task of benchmarking numerical optimization algorithms to the greatest possible…

Artificial Intelligence · Computer Science 2020-09-10 Nikolaus Hansen , Anne Auger , Raymond Ros , Olaf Mersmann , Tea Tušar , Dimo Brockhoff

For decades, researchers in fields, such as the natural and social sciences, have been verifying causal relationships and investigating hypotheses that are now well-established or understood as truth. These causal mechanisms are properties…

Machine Learning · Computer Science 2019-12-02 Trent Kyono , Mihaela van der Schaar

There has been an increasing interest in enhancing the fairness of machine learning (ML). Despite the growing number of fairness-improving methods, we lack a systematic understanding of the trade-offs among factors considered in the ML…

Machine Learning · Computer Science 2023-10-04 Zhenlan Ji , Pingchuan Ma , Shuai Wang , Yanhui Li

Although optimization is the longstanding algorithmic backbone of machine learning, new models still require the time-consuming implementation of new solvers. As a result, there are thousands of implementations of optimization algorithms…

Machine Learning · Computer Science 2019-06-03 Sören Laue , Matthias Mitterreiter , Joachim Giesen

We present a computational motivation for restricted maximum likelihood (REML) estimation in linear mixed models using an expectation--maximization (EM) algorithm. At each iteration, maximum likelihood (ML) and REML solve the same…

Computation · Statistics 2026-02-11 Andrew T. Karl

Classical machine learning models struggle with learning and prediction tasks on data sets exhibiting long-range correlations. Previously, the existence of a long-range correlational structure known as contextuality was shown to inhibit…

Quantum Physics · Physics 2026-04-28 Mariesa H. Teo , Willers Yang , James Sud , Teague Tomesh , Frederic T. Chong , Eric R. Anschuetz

We consider the optimization of an uncertain objective over continuous and multi-dimensional decision spaces in problems in which we are only provided with observational data. We propose a novel algorithmic framework that is tractable,…

Machine Learning · Statistics 2018-10-30 Dimitris Bertsimas , Christopher McCord

Factor analysis, a classical multivariate statistical technique is popularly used as a fundamental tool for dimensionality reduction in statistics, econometrics and data science. Estimation is often carried out via the Maximum Likelihood…

Optimization and Control · Mathematics 2018-01-19 Koulik Khamaru , Rahul Mazumder

We address the problem of policy selection in contextual stochastic optimization (CSO), where covariates are available as contextual information and decisions must satisfy hard feasibility constraints. In many CSO settings, multiple…

Machine Learning · Computer Science 2026-05-29 Caio de Prospero Iglesias , Kimberly Villalobos Carballo , Dimitris Bertsimas

Bayesian optimization is a powerful method for optimizing black-box functions with limited function evaluations. Recent works have shown that optimization in a latent space through deep generative models such as variational autoencoders…

Machine Learning · Computer Science 2023-11-21 Seunghun Lee , Jaewon Chu , Sihyeon Kim , Juyeon Ko , Hyunwoo J. Kim

The estimation of causal effects with observational data continues to be a very active research area. In recent years, researchers have developed new frameworks which use machine learning to relax classical assumptions necessary for the…

Machine Learning · Statistics 2024-05-01 Jonathan Fuhr , Philipp Berens , Dominik Papies

Causal effect estimation from observational data is a challenging problem, especially with high dimensional data and in the presence of unobserved variables. The available data-driven methods for tackling the problem either provide an…

Methodology · Statistics 2022-07-25 Debo Cheng , Jiuyong Li , Lin Liu , Jiji Zhang , Jixue Liu , Thuc Duy Le
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