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Graph representation learning is fundamental for analyzing graph-structured data. Exploring invariant graph representations remains a challenge for most existing graph representation learning methods. In this paper, we propose a cross-view…

Machine Learning · Computer Science 2025-04-15 Jie Chen , Hua Mao , Wai Lok Woo , Chuanbin Liu , Xi Peng

Molecular structure-property relationships are key to molecular engineering for materials and drug discovery. The rise of deep learning offers a new viable solution to elucidate the structure-property relationships directly from chemical…

Machine Learning · Computer Science 2018-10-09 Seongok Ryu , Jaechang Lim , Seung Hwan Hong , Woo Youn Kim

Graph recommender (GR) is a type of graph neural network (GNNs) encoder that is customized for extracting information from the user-item interaction graph. Due to its strong performance on the recommendation task, GR has gained significant…

Machine Learning · Computer Science 2024-07-26 Wenjie Yang , Shengzhong Zhang , Jiaxing Guo , Zengfeng Huang

Graph contrastive learning (GCL) aims to learn representations from unlabeled graph data in a self-supervised manner and has developed rapidly in recent years. However, edgelevel contrasts are not well explored by most existing GCL methods.…

Machine Learning · Computer Science 2024-12-17 Yujun Li , Hongyuan Zhang , Yuan Yuan

Heterogeneous Graphs (HGs) effectively model complex relationships in the real world through multi-type nodes and edges. In recent years, inspired by self-supervised learning (SSL), contrastive learning (CL)-based Heterogeneous Graphs…

Machine Learning · Computer Science 2025-05-06 Yu Wang , Lei Sang , Yi Zhang , Yiwen Zhang , Xindong Wu

Unsupervised graph representation learning is a non-trivial topic. The success of contrastive methods in the unsupervised representation learning on structured data inspires similar attempts on the graph. Existing graph contrastive learning…

Machine Learning · Computer Science 2024-04-02 Tianyu Zhang , Yuxiang Ren , Wenzheng Feng , Weitao Du , Xuecang Zhang

Graph Convolutional Network (GCN) has exhibited remarkable potential in improving graph-based clustering. To handle the general clustering scenario without a prior graph, these models estimate an initial graph beforehand to apply GCN.…

Machine Learning · Computer Science 2024-04-04 Mulin Chen , Bocheng Wang , Xuelong Li

We consider graph representation learning in a self-supervised manner. Graph neural networks (GNNs) use neighborhood aggregation as a core component that results in feature smoothing among nodes in proximity. While successful in various…

Machine Learning · Computer Science 2021-07-20 Wei Zhuo , Guang Tan

Molecular property prediction is of crucial importance in many disciplines such as drug discovery, molecular biology, or material and process design. The frequently employed quantitative structure-property/activity relationships…

Biomolecules · Quantitative Biology 2024-01-17 Jan G. Rittig , Qinghe Gao , Manuel Dahmen , Alexander Mitsos , Artur M. Schweidtmann

Graph contrastive learning (GCL) has achieved remarkable success by following the computer vision paradigm of preserving absolute similarity between augmented views. However, this approach faces fundamental challenges in graphs due to their…

Machine Learning · Computer Science 2025-05-13 Zhiyuan Ning , Pengfei Wang , Ziyue Qiao , Pengyang Wang , Yuanchun Zhou

The graph neural network (GNN) has been a powerful deep-learning tool in chemistry domain, due to its close connection with molecular graphs. Most GNN models collect and update atom and molecule features from the fed atom (and, in some…

Chemical Physics · Physics 2022-03-18 Yeji Kim , Yoonho Jeong , Jihoo Kim , Eok Kyun Lee , Won June Kim , Insung S. Choi

Graph Contrastive Learning (GCL) has shown superior performance in representation learning in graph-structured data. Despite their success, most existing GCL methods rely on prefabricated graph augmentation and homophily assumptions. Thus,…

Machine Learning · Computer Science 2024-02-27 Teng Xiao , Huaisheng Zhu , Zhengyu Chen , Suhang Wang

Ground-state 3D geometries of molecules are essential for many molecular analysis tasks. Modern quantum mechanical methods can compute accurate 3D geometries but are computationally prohibitive. Currently, an efficient alternative to…

Chemical Physics · Physics 2023-05-24 Zhao Xu , Yaochen Xie , Youzhi Luo , Xuan Zhang , Xinyi Xu , Meng Liu , Kaleb Dickerson , Cheng Deng , Maho Nakata , Shuiwang Ji

Leveraging the diversity and quantity of data provided by various graph-structured data augmentations while preserving intrinsic semantic information is challenging. Additionally, successive layers in graph neural network (GNN) tend to…

Machine Learning · Computer Science 2026-03-19 Jie Chen , Hua Mao , Chuanbin Liu , Zhu Wang , Xi Peng

Recent advances in molecular representation learning have produced highly effective encodings of molecules for numerous cheminformatics and bioinformatics tasks. However, extracting general chemical insight while balancing predictive…

Machine Learning · Computer Science 2025-09-26 Rahul Khorana

This paper studies the problem of graph-level clustering, which is a novel yet challenging task. This problem is critical in a variety of real-world applications such as protein clustering and genome analysis in bioinformatics. Recent years…

Machine Learning · Computer Science 2023-03-09 Wei Ju , Yiyang Gu , Binqi Chen , Gongbo Sun , Yifang Qin , Xingyuming Liu , Xiao Luo , Ming Zhang

Graph Contrastive Learning (GCL) seeks to learn nodal or graph representations that contain maximal consistent information from graph-structured data. While node-level contrasting modes are dominating, some efforts commence to explore…

Machine Learning · Computer Science 2024-09-13 Zhenhao Zhao , Minhong Zhu , Chen Wang , Sijia Wang , Jiqiang Zhang , Li Chen , Weiran Cai

Accurate prediction of blood-brain barrier permeability (BBBP) is essential for central nervous system (CNS) drug development. While graph neural networks (GNNs) have advanced molecular property prediction, they often rely on molecular…

Machine Learning · Computer Science 2025-12-09 Trung Nguyen , Md Masud Rana , Farjana Tasnim Mukta , Chang-Guo Zhan , Duc Duy Nguyen

Graph Contrastive Learning (GCL) has emerged as a powerful tool for extracting consistent representations from graphs, independent of labeled information. However, existing methods predominantly focus on undirected graphs, disregarding the…

Machine Learning · Computer Science 2025-10-21 Daohan Su , Yang Zhang , Xunkai Li , Rong-Hua Li , Guoren Wang

In the field of chemistry, the objective is to create novel molecules with desired properties, facilitating accurate property predictions for applications such as material design and drug screening. However, existing graph deep learning…

Machine Learning · Computer Science 2024-08-28 Sakhinana Sagar Srinivas , Venkataramana Runkana
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