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Uncertainty quantification (UQ) is crucial in safety-critical applications such as medical image segmentation. Total uncertainty is typically decomposed into data-related aleatoric uncertainty (AU) and model-related epistemic uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Jakob Lønborg Christensen , Vedrana Andersen Dahl , Morten Rieger Hannemose , Anders Bjorholm Dahl , Christian F. Baumgartner

Multimodal deep learning holds promise for improving clinical prediction by integrating diverse patient data, including text, imaging, time-series, and structured demographics. Contrastive learning facilitates this integration by producing…

Machine Learning · Computer Science 2025-07-08 Michal Golovanevsky , Pranav Mahableshwarkar , Carsten Eickhoff , Ritambhara Singh

In this work, we examine the effectiveness of an uncertainty quantification framework known as Evidential Deep Learning applied in the context of biomedical image segmentation. This class of models involves assigning Dirichlet distributions…

Image and Video Processing · Electrical Eng. & Systems 2025-04-24 Hai Siong Tan , Kuancheng Wang , Rafe Mcbeth

Accurate uncertainty estimation is a critical need for the medical imaging community. A variety of methods have been proposed, all direct extensions of classification uncertainty estimations techniques. The independent pixel-wise…

Image and Video Processing · Electrical Eng. & Systems 2022-06-16 Thierry Judge , Olivier Bernard , Mihaela Porumb , Agis Chartsias , Arian Beqiri , Pierre-Marc Jodoin

We propose a patch sampling strategy based on a sequential Monte-Carlo method for high resolution image classification in the context of Multiple Instance Learning. When compared with grid sampling and uniform sampling techniques, it…

Computer Vision and Pattern Recognition · Computer Science 2019-01-01 Marc Combalia , Veronica Vilaplana

Increased usage of automated tools like deep learning in medical image segmentation has alleviated the bottleneck of manual contouring. This has shifted manual labour to quality assessment (QA) of automated contours which involves detecting…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Prerak Mody , Nicolas F. Chaves-de-Plaza , Chinmay Rao , Eleftheria Astrenidou , Mischa de Ridder , Nienke Hoekstra , Klaus Hildebrandt , Marius Staring

The deployment of deep neural networks in safety-critical systems necessitates reliable and efficient uncertainty quantification (UQ). A practical and widespread strategy for UQ is repurposing stochastic regularizers as scalable approximate…

Machine Learning · Computer Science 2026-04-15 Adam T. Müller , Tobias Rögelein , Nicolaj C. Stache

In semi-supervised medical image segmentation, most previous works draw on the common assumption that higher entropy means higher uncertainty. In this paper, we investigate a novel method of estimating uncertainty. We observe that, when…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Yinghuan Shi , Jian Zhang , Tong Ling , Jiwen Lu , Yefeng Zheng , Qian Yu , Lei Qi , Yang Gao

The multilevel Monte Carlo (MLMC) method has proven to be an effective variance-reduction statistical method for Uncertainty quantification in PDE models. It combines approximations at different levels of accuracy using a hierarchy of…

Numerical Analysis · Mathematics 2019-11-28 Santiago Badia , Jerrad Hampton , Javier Principe

Uncertainty quantification of deep neural networks has become an active field of research and plays a crucial role in various downstream tasks such as active learning. Recent advances in evidential deep learning shed light on the direct…

Machine Learning · Computer Science 2023-11-21 Ruxiao Duan , Brian Caffo , Harrison X. Bai , Haris I. Sair , Craig Jones

We have developed an Uncertainty Quantification process for multistep pipelines and applied it to the ACORN particle tracking pipeline. All our experiments are made using the TrackML open dataset. Using the Monte Carlo Dropout method, we…

High Energy Physics - Experiment · Physics 2025-08-25 Lukas Péron , Paolo Calafiura , Xiangyang Ju , Jay Chan

The trace of a matrix function f(A), most notably of the matrix inverse, can be estimated stochastically using samples< x,f(A)x> if the components of the random vectors x obey an appropriate probability distribution. However such a…

Numerical Analysis · Mathematics 2021-08-26 Andreas Frommer , Mostafa Nasr Khalil , Gustavo Ramirez-Hidalgo

Estimating and disentangling epistemic uncertainty, uncertainty that is reducible with more training data, and aleatoric uncertainty, uncertainty that is inherent to the task at hand, is critically important when applying machine learning…

Machine Learning · Computer Science 2024-11-08 Matthew A. Chan , Maria J. Molina , Christopher A. Metzler

In the domain of medical imaging, many supervised learning based methods for segmentation face several challenges such as high variability in annotations from multiple experts, paucity of labelled data and class imbalanced datasets. These…

Computer Vision and Pattern Recognition · Computer Science 2025-05-15 Soumick Chatterjee , Franziska Gaidzik , Alessandro Sciarra , Hendrik Mattern , Gábor Janiga , Oliver Speck , Andreas Nürnberger , Sahani Pathiraja

Uncertainty estimates of modern neuronal networks provide additional information next to the computed predictions and are thus expected to improve the understanding of the underlying model. Reliable uncertainties are particularly…

Computer Vision and Pattern Recognition · Computer Science 2018-06-11 Alain Jungo , Raphael Meier , Ekin Ermis , Evelyn Herrmann , Mauricio Reyes

Uncertainty estimation in deep learning has become a leading research field in medical image analysis due to the need for safe utilisation of AI algorithms in clinical practice. Most approaches for uncertainty estimation require sampling…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Kaisar Kushibar , Víctor Manuel Campello , Lidia Garrucho Moras , Akis Linardos , Petia Radeva , Karim Lekadir

In this work, we study various hybrid models of entropy-based and representativeness sampling techniques in the context of active learning in medical segmentation, in particular examining the role of UMAP (Uniform Manifold Approximation and…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 H. S. Tan , Kuancheng Wang , Rafe Mcbeth

We introduce a novel Multi-Order Monte Carlo approach for uncertainty quantification in the context of multiscale time-dependent partial differential equations. The new framework leverages Implicit-Explicit Runge-Kutta time integrators to…

Numerical Analysis · Mathematics 2026-04-08 Giulia Bertaglia , Walter Boscheri , Lorenzo Pareschi

Uncertainty estimation, which provides a means of building explainable neural networks for medical imaging applications, have mostly been studied for single deep learning models that focus on a specific task. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Leonhard F. Feiner , Martin J. Menten , Kerstin Hammernik , Paul Hager , Wenqi Huang , Daniel Rueckert , Rickmer F. Braren , Georgios Kaissis

Uncertainty estimation is essential to make neural networks trustworthy in real-world applications. Extensive research efforts have been made to quantify and reduce predictive uncertainty. However, most existing works are designed for…

Machine Learning · Computer Science 2022-10-07 Myong Chol Jung , He Zhao , Joanna Dipnall , Belinda Gabbe , Lan Du