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Purpose: To develop neural network (NN)-based quantitative MRI parameter estimators with minimal bias and a variance close to the Cram\'er-Rao bound. Theory and Methods: We generalize the mean squared error loss to control the bias and…

Medical Physics · Physics 2024-05-07 Andrew Mao , Sebastian Flassbeck , Jakob Assländer

The Cram\'er-Rao bound (CRB), a well-known lower bound on the performance of any unbiased parameter estimator, has been used to study a wide variety of problems. However, to obtain the CRB, requires an analytical expression for the…

Machine Learning · Computer Science 2022-10-11 Hai Victor Habi , Hagit Messer , Yoram Bresler

The Bayesian Cram\'er-Rao bound (CRB) provides a lower bound on the mean square error of any Bayesian estimator under mild regularity conditions. It can be used to benchmark the performance of statistical estimators, and provides a…

Machine Learning · Statistics 2024-09-09 Evan Scope Crafts , Xianyang Zhang , Bo Zhao

We extend the traditional framework for estimating subspace bases that maximize the preserved signal energy to additionally preserve the Cram\'er-Rao bound (CRB) of the biophysical parameters and, ultimately, improve accuracy and precision…

Medical Physics · Physics 2025-10-28 Andrew Mao , Sebastian Flassbeck , Cem Gultekin , Jakob Assländer

This paper derives a general expression for the Cram\'er-Rao bound (CRB) of wireless localization algorithms using range measurements subject to bias corruption. Specifically, the a priori knowledge about which range measurements are…

Information Theory · Computer Science 2011-11-10 Tao Wang

In some estimation problems, not all the parameters can be identified, which results in singularity of the Fisher Information Matrix (FIM). The Cram\'er-Rao Bound (CRB), which is the inverse of the FIM, is then not defined. To regularize…

Information Theory · Computer Science 2018-07-24 Elisabeth de Carvalho , Dirk Slock

This paper investigates the asymptotic behavior of the deterministic and stochastic Cram\'er-Rao Bounds (CRB) for semi-blind channel estimation in massive multiple-input multiple-output (MIMO) systems. We derive and analyze mathematically…

Signal Processing · Electrical Eng. & Systems 2025-07-15 Xue Zhang , Abla Kammoun , Mohamed-Slim Alouini

Advanced super-resolution imaging techniques require specific approaches for accurate and consistent estimation of the achievable spatial resolution. Fisher information supplied to Cramer-Rao bound (CRB) has proved to be a powerful and…

Estimation under model misspecification arises in many signal processing problems, where the assumed observation model deviates from the true data-generating mechanism due to errors or simplifications. The misspecified Cram\'er-Rao bound…

Statistics Theory · Mathematics 2026-05-21 Malaak Khatib , Nadav Harel , Joseph Tabrikian , Tirza Routtenberg

We revisit the problem of computing submatrices of the Cram\'er-Rao bound (CRB), which lower bounds the variance of any unbiased estimator of a vector parameter $\vth$. We explore iterative methods that avoid direct inversion of the Fisher…

Information Theory · Computer Science 2015-06-04 Paul Tune

This paper presents a Cramer-Rao bound (CRB) for the estimation of parameters confined to an arbitrary set. Unlike existing results that rely on equality or inequality constraints, manifold structures, or the nonsingularity of the Fisher…

Signal Processing · Electrical Eng. & Systems 2026-01-28 Heedong Do , Angel Lozano

The goal of this paper is to characterize the best achievable performance for the problem of estimating an unknown parameter having a sparse representation. Specifically, we consider the setting in which a sparsely representable…

Statistics Theory · Mathematics 2009-09-29 Zvika Ben-Haim , Yonina C. Eldar

Bounding the optimal precision in parameter estimation tasks is of central importance for technological applications. In the regime of a small number of measurements, or that of low signal-to-noise ratios, the meaning of common frequentist…

Quantum Physics · Physics 2024-02-23 Valentin Gebhart , Manuel Gessner , Augusto Smerzi

In modern radar systems, precise target localization using azimuth and velocity estimation is paramount. Traditional unbiased estimation methods have utilized gradient descent algorithms to reach the theoretical limits of the Cramer Rao…

Signal Processing · Electrical Eng. & Systems 2024-04-24 Shyam Venkatasubramanian , Sandeep Gogineni , Bosung Kang , Muralidhar Rangaswamy

Purpose: To develop a method for optimizing pulsed saturation transfer MR fingerprinting (ST MRF) acquisition. Methods: The Cram\'er-Rao bound (CRB) for variance assessment was employed on Bloch-McConnell-based simulated signals, followed…

Medical Physics · Physics 2025-10-21 Nikita Vladimirov , Moritz Zaiss , Or Perlman

Analytical phase demodulation algorithms in optical interferometry typically fail to reach the theoretical sensitivity limit set by the Cram\'er-Rao bound (CRB). We show that deep neural networks (DNNs) can perform efficient phase…

Image and Video Processing · Electrical Eng. & Systems 2020-08-26 Jacob Black , Shichao Chen , Joseph G. Thomas , Yizheng Zhu

The Bayesian Cram\'er-Rao bound (BCRB) is a crucial tool in signal processing for assessing the fundamental limitations of any estimation problem as well as benchmarking within a Bayesian frameworks. However, the BCRB cannot be computed…

Signal Processing · Electrical Eng. & Systems 2025-02-11 Hai Victor Habi , Hagit Messer , Yoram Bresler

Artificial neural networks have become important tools to harness the complexity of disordered or random photonic systems. Recent applications include the recovery of information from light that has been scrambled during propagation through…

The Cram\'er-Rao bound serves as a crucial lower limit for the mean squared error of an estimator in frequentist parameter estimation. Paradoxically, it requires highly accurate prior knowledge of the estimated parameter for constructing…

Quantum Physics · Physics 2025-04-21 Javier Navarro , Ricard Ravell Rodríguez , Mikel Sanz

In this paper, we derive the Cramer-Rao bound (CRB) for joint target position and velocity estimation using an active or passive distributed radar network under more general, and practically occurring, conditions than assumed in previous…

Statistics Theory · Mathematics 2016-04-20 Qian He , Jianbin Hu , Rick S. Blum , Yonggang Wu
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