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Current Large Language Models (LLMs) benchmarks are often based on open-ended or close-ended QA evaluations, avoiding the requirement of human labor. Close-ended measurements evaluate the factuality of responses but lack expressiveness.…

Large Language Models (LLMs) increasingly support applications in a wide range of domains, some with potential high societal impact such as biomedicine, yet their reliability in realistic use cases is under-researched. In this work we…

Uncertainty is a fundamental challenge in medical practice, but current medical AI systems fail to explicitly quantify or communicate uncertainty in a way that aligns with clinical reasoning. Existing XAI works focus on interpreting model…

Artificial Intelligence · Computer Science 2025-09-24 Xiuyi Fan

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

Quantum computing holds transformative potential for medical applications, yet efficiently preparing quantum states from complex medical data remains a fundamental challenge. This survey provides a comprehensive examination of current…

Quantum Physics · Physics 2025-08-08 Nikhil Kumar Rajput , Riya Bansal

Recent advancements in AI applications to healthcare have shown incredible promise in surpassing human performance in diagnosis and disease prognosis. With the increasing complexity of AI models, however, concerns regarding their opacity,…

Machine Learning · Computer Science 2023-08-17 Munib Mesinovic , Peter Watkinson , Tingting Zhu

AI systems have been widely adopted across various domains in the real world. However, in high-value, sensitive, or safety-critical applications such as self-management for personalized health or food recommendation with a specific purpose…

Artificial Intelligence · Computer Science 2022-06-28 Amit Sheth , Manas Gaur , Kaushik Roy , Revathy Venkataraman , Vedant Khandelwal

Current evaluation of large language models (LLMs) overwhelmingly prioritizes accuracy; however, in real-world and safety-critical applications, the ability to abstain when uncertain is equally vital for trustworthy deployment. We introduce…

Computation and Language · Computer Science 2026-01-23 Sravanthi Machcha , Sushrita Yerra , Sahil Gupta , Aishwarya Sahoo , Sharmin Sultana , Hong Yu , Zonghai Yao

With the advent of Large Language Models (LLMs), medical artificial intelligence (AI) has experienced substantial technological progress and paradigm shifts, highlighting the potential of LLMs to streamline healthcare delivery and improve…

Computation and Language · Computer Science 2024-12-10 Lei Liu , Xiaoyan Yang , Junchi Lei , Yue Shen , Jian Wang , Peng Wei , Zhixuan Chu , Zhan Qin , Kui Ren

Question Answering (QA) on narrative text poses a unique challenge to current systems, requiring a deep understanding of long, complex documents. However, the reliability of NarrativeQA, the most widely used benchmark in this domain, is…

Computation and Language · Computer Science 2025-10-16 Tommaso Bonomo , Luca Gioffré , Roberto Navigli

Clinical Question-Answering (CQA) industry systems are increasingly rely on Large Language Models (LLMs), yet their deployment is often guided by the assumption that domain-specific fine-tuning is essential. Although specialised medical…

Computation and Language · Computer Science 2026-01-21 Sushant Kumar Ray , Gautam Siddharth Kashyap , Sahil Tripathi , Nipun Joshi , Vijay Govindarajan , Rafiq Ali , Jiechao Gao , Usman Naseem

Question Answering (QA) is one of the most important natural language processing (NLP) tasks. It aims using NLP technologies to generate a corresponding answer to a given question based on the massive unstructured corpus. With the…

Computation and Language · Computer Science 2022-07-01 Zhen Wang

In spite of the strong performance of machine learning (ML) models in radiology, they have not been widely accepted by radiologists, limiting clinical integration. A key reason is the lack of explainability, which ensures that model…

Human-Computer Interaction · Computer Science 2026-04-14 Sara Ketabi , Matthias W. Wagner , Birgit Betina Ertl-Wagner , Greg A. Jamieson , Farzad Khalvati

Machine learning is expected to fuel significant improvements in medical care. To ensure that fundamental principles such as beneficence, respect for human autonomy, prevention of harm, justice, privacy, and transparency are respected,…

The increasing rate of information pollution on the Web requires novel solutions to tackle that. Question Answering (QA) interfaces are simplified and user-friendly interfaces to access information on the Web. However, similar to other AI…

Information Retrieval · Computer Science 2019-07-08 Saeedeh Shekarpour , Faisal Alshargi

Physicians are--and feel--ethically, professionally, and legally responsible for patient outcomes, buffering patients from harmful AI determinations from medical AI systems. Many have called for explainable AI (XAI) systems to help…

Human-Computer Interaction · Computer Science 2025-07-23 Gennie Mansi , Mark Riedl

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

Electronic health records (EHRs) hold significant value for research and applications. As a new way of information extraction, question answering (QA) can extract more flexible information than conventional methods and is more accessible to…

Computation and Language · Computer Science 2024-02-20 Huaiyuan Ying , Sheng Yu

The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their responses. To address this, we present Answered with Evidence, a framework for evaluating…

Machine Learning · Computer Science 2025-07-08 Julian D Baldwin , Christina Dinh , Arjun Mukerji , Neil Sanghavi , Saurabh Gombar

The widespread utilization of AI systems has drawn attention to the potential impacts of such systems on society. Of particular concern are the consequences that prediction errors may have on real-world scenarios, and the trust humanity…

Computers and Society · Computer Science 2021-06-22 Mary Roszel , Robert Norvill , Jean Hilger , Radu State