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Drug discovery seeks molecules (ligands) that bind strongly and selectively to a target protein. However, fewer than 5% of candidate ligands pass the bar for even the early stages of drug discovery. Furthermore, we want methods that work…

Machine Learning · Computer Science 2026-05-08 Rahul Nandakumar , Ben Fauber , Deepayan Chakrabarti

Recent developments in deep learning have led to a significant innovation in various classic and practical subjects, including speech recognition, computer vision, question answering, information retrieval and so on. In the context of…

Computation and Language · Computer Science 2019-11-01 Li-Phen Yen , Zhen-Yu Wu , Kuan-Yu Chen

Reinforcement learning has emerged as an effective paradigm for training large language models to interleave reasoning with search engine calls. However, existing approaches face a fundamental credit assignment problem: methods like…

Computation and Language · Computer Science 2026-04-02 Chris Samarinas , Haw-Shiuan Chang , Hamed Zamani

Speculative decoding is a powerful technique for reducing the latency of Large Language Models (LLMs), offering a fault-tolerant framework that enables the use of highly compressed draft models. In this work, we introduce Self-Distilled…

Computation and Language · Computer Science 2025-06-03 Mike Lasby , Nish Sinnadurai , Valavan Manohararajah , Sean Lie , Yani Ioannou , Vithursan Thangarasa

Query expansion is an effective approach for mitigating vocabulary mismatch between queries and documents in information retrieval. One recent line of research uses language models to generate query-related contexts for expansion. Along…

Computation and Language · Computer Science 2022-10-14 Linqing Liu , Minghan Li , Jimmy Lin , Sebastian Riedel , Pontus Stenetorp

Dense passage retrieval (DPR) is the first step in the retrieval augmented generation (RAG) paradigm for improving the performance of large language models (LLM). DPR fine-tunes pre-trained networks to enhance the alignment of the…

Computation and Language · Computer Science 2024-10-07 Benjamin Reichman , Larry Heck

We propose SLoPe, a Double-Pruned Sparse Plus Lazy Low-rank Adapter Pretraining method for LLMs that improves the accuracy of sparse LLMs while accelerating their pretraining and inference and reducing their memory footprint. Sparse…

Machine Learning · Computer Science 2025-01-28 Mohammad Mozaffari , Amir Yazdanbakhsh , Zhao Zhang , Maryam Mehri Dehnavi

Learned Sparse Retrieval (LSR) has traditionally focused on small-scale encoder-only transformer architectures. With the advent of large-scale pre-trained language models, their capability to generate sparse representations for retrieval…

Information Retrieval · Computer Science 2025-04-28 Jingfen Qiao , Thong Nguyen , Evangelos Kanoulas , Andrew Yates

While the flexible capabilities of large language models (LLMs) allow them to answer a range of queries based on existing learned knowledge, information retrieval to augment generation is an important tool to allow LLMs to answer questions…

Information Retrieval · Computer Science 2023-11-23 Guy Zyskind , Tobin South , Alex Pentland

Previous research on word embeddings has shown that sparse representations, which can be either learned on top of existing dense embeddings or obtained through model constraints during training time, have the benefit of increased…

Computation and Language · Computer Science 2018-09-26 Valentin Trifonov , Octavian-Eugen Ganea , Anna Potapenko , Thomas Hofmann

This paper proposes a dual skipping guidance scheme with hybrid scoring to accelerate document retrieval that uses learned sparse representations while still delivering a good relevance. This scheme uses both lexical BM25 and learned neural…

Information Retrieval · Computer Science 2022-04-26 Yifan Qiao , Yingrui Yang , Haixin Lin , Tianbo Xiong , Xiyue Wang , Tao Yang

Traditional pruning methods are known to be challenging to work in Large Language Models (LLMs) for Generative AI because of their unaffordable training process and large computational demands. For the first time, we introduce the…

Machine Learning · Computer Science 2024-03-25 Yun Li , Lin Niu , Xipeng Zhang , Kai Liu , Jianchen Zhu , Zhanhui Kang

Reinforcement learning (RL) has become an effective way to improve prompt alignment and perceptual quality in diffusion and flow-matching generators. A critical step for applying online RL to flow matching is turning the deterministic…

Machine Learning · Computer Science 2026-05-25 Jade Zou , Tao Huang , Weijie Kong , Junzhe Li , Yue Wu , Qi Tian , Jiangfeng Xiong , Jianwei Zhang , Liefeng Bo , Zhao Zhong

Pseudo-relevance feedback mechanisms, from Rocchio to the relevance models, have shown the usefulness of expanding and reweighting the users' initial queries using information occurring in an initial set of retrieved documents, known as the…

Information Retrieval · Computer Science 2021-07-02 Xiao Wang , Craig Macdonald , Nicola Tonellotto , Iadh Ounis

PLAID, an efficient implementation of the ColBERT late interaction bi-encoder using pretrained language models for ranking, consistently achieves state-of-the-art performance in monolingual, cross-language, and multilingual retrieval. PLAID…

Information Retrieval · Computer Science 2024-05-03 Dawn Lawrie , Efsun Kayi , Eugene Yang , James Mayfield , Douglas W. Oard

The dual-encoder has become the de facto architecture for dense retrieval. Typically, it computes the latent representations of the query and document independently, thus failing to fully capture the interactions between the query and…

Computation and Language · Computer Science 2023-10-31 Xingwei He , Yeyun Gong , A-Long Jin , Hang Zhang , Anlei Dong , Jian Jiao , Siu Ming Yiu , Nan Duan

Search behaviour is characterised using synonymy and polysemy as users often want to search information based on meaning. Semantic representation strategies represent a move towards richer associative connections that can adequately capture…

Information Retrieval · Computer Science 2026-02-06 Niall McCarroll , Kevin Curran , Eugene McNamee , Angela Clist , Andrew Brammer

The sparse, hierarchical, and modular processing of natural signals is related to the ability of humans to recognize objects with high accuracy. In this study, we report a sparse feature processing and encoding method, which improved the…

Computer Vision and Pattern Recognition · Computer Science 2014-11-20 Swathikiran Sudhakarana , Alex Pappachen James

This study investigates the position bias in information retrieval, where models tend to overemphasize content at the beginning of passages while neglecting semantically relevant information that appears later. To analyze the extent and…

Information Retrieval · Computer Science 2025-09-19 Ziyang Zeng , Dun Zhang , Jiacheng Li , Panxiang Zou , Yudong Zhou , Yuqing Yang

Behavioral patterns captured in embeddings learned from interaction data are pivotal across various stages of production recommender systems. However, in the initial retrieval stage, practitioners face an inherent tradeoff between embedding…

Information Retrieval · Computer Science 2026-02-11 Vojtěch Vančura , Martin Spišák , Rodrigo Alves , Ladislav Peška