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Efficient sampling in biomolecular simulations is critical for accurately capturing the complex dynamical behaviors of biological systems. Adaptive sampling techniques aim to improve efficiency by focusing computational resources on the…

Biomolecules · Quantitative Biology 2024-10-22 Hassan Nadeem , Diwakar Shukla

We consider online resource allocation under a typical non-profit setting, where limited or even scarce resources are administered by a not-for-profit organization like a government. We focus on the internal-equity by assuming that arriving…

Computer Science and Game Theory · Computer Science 2021-12-10 Pan Xu , Yifan Xu

We present a distributed resource allocation strategy to control an epidemic outbreak in a networked population based on a Distributed Alternating Direction Method of Multipliers (D-ADMM) algorithm. We consider a linearized Susceptible-…

Systems and Control · Computer Science 2015-01-09 Chinwendu Enyioha , Ali Jadbabaie , Victor Preciado , George J. Pappas

The COVID-19 vaccine development, manufacturing, transportation, and administration proved an extreme logistics operation of global magnitude. Global vaccination levels, however, remain a key concern in preventing the emergence of new…

General Economics · Economics 2025-01-10 Sharika J. Hegde , Max T. M. Ng , Marcos Rios , Hani S. Mahmassani , Ying Chen , Karen Smilowitz

If we can lower the number of people needed to vaccinate for a community to be immune against contagious diseases, we can save resources and life. A key to reach such a lower threshold of immunization is to find and vaccinate people who,…

Populations and Evolution · Quantitative Biology 2012-10-10 Sungmin Lee , Luis E. C. Rocha , Fredrik Liljeros , Petter Holme

Vaccination has played an important role in preventing the spread of infectious diseases. However, the limited availability of vaccines and personnel at the roll-out of a new vaccine and the costs of vaccination campaigns often limit how…

Physics and Society · Physics 2026-01-27 Rowan Hoogervorst , Evelien van der Hurk , David Pisinger

The COVID-19 pandemic has placed immense strain on hospital systems worldwide, leading to critical capacity challenges. This research proposes a two-part framework to optimize hospital capacity through patient relocation strategies. The…

Artificial Intelligence · Computer Science 2026-03-18 Sadaf Tabatabaee , Hicham El Baz , Mohammed Khalil Ghali , Nagendra N. Nagarur

Recently, it has been shown how sampling actions from the predictive distribution over the optimal action-sometimes called Thompson sampling-can be applied to solve sequential adaptive control problems, when the optimal policy is known for…

Artificial Intelligence · Computer Science 2014-09-24 Pedro A. Ortega , Daniel A. Braun

We investigate stochastic extinction in an epidemic model and the impact of random vaccinations in large populations formulated in terms of an optimal escape path. We find that different random vaccination strategies can have widely…

Biological Physics · Physics 2007-11-12 Alexandra S. Landsman , Ira B. Schwartz

We introduce a novel compartmental model accounting for the effects of vaccine efficacy, deployment rates and timing of initiation of deployment. We simulate different scenarios and initial conditions, and we find that higher abundancy and…

Populations and Evolution · Quantitative Biology 2022-06-28 Omar El Deeb , Maya Jalloul

During the COVID-19 pandemic, many organizations (e.g. businesses, companies, government facilities, etc.) have attempted to reduce infection risk by employing partial home office strategies. However, working from home can also reduce…

Data Structures and Algorithms · Computer Science 2022-04-05 Mansoor Davoodi , Abhishek Senapati , Adam Mertel , Weronika Schlechte-Welnicz , Justin M. Calabrese

The COVID-19 pandemic has led to a need for widespread and rapid vaccine development. As several vaccines have recently been approved for human use or are in different stages of development, governments across the world are preparing…

Motivated by the increasing number of COVID-19 cases that have been observed in many countries after the vaccination and relaxation of non-pharmaceutical interventions, we propose a mathematical model on time-varying networks for the spread…

Dynamical Systems · Mathematics 2022-03-09 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

In this paper, we study the problem of minimizing the spread of a viral epidemic when immunization takes a non-negligible amount of time to take into effect. Specifically, our problem is to determine which set of nodes to be vaccinated when…

Social and Information Networks · Computer Science 2023-07-14 Shiju Li , Xin Huang , Chul-Ho Lee , Do Young Eun

We propose a new method to immunize populations or computer networks against epidemics which is more efficient than any method considered before. The novelty of our method resides in the way of determining the immunization targets. First we…

Physics and Society · Physics 2015-06-03 Christian M. Schneider , Tamara Mihaljev , Hans J. Herrmann

A COVID-19 vaccine is our best bet for mitigating the ongoing onslaught of the pandemic. However, vaccine is also expected to be a limited resource. An optimal allocation strategy, especially in countries with access inequities and temporal…

The COVID-19 pandemic left its unique mark on the 21st century as one of the most significant disasters in history, triggering governments all over the world to respond with a wide range of interventions. However, these restrictions come…

Computational Engineering, Finance, and Science · Computer Science 2021-06-02 Assem Zhunis , Tung-Duong Mai , Sundong Kim

Most countries have started vaccinating people against COVID-19. However, due to limited production capacities and logistical challenges it will take months/years until herd immunity is achieved. Therefore, vaccination and social distancing…

Physics and Society · Physics 2021-04-22 Sara Grundel , Stefan Heyder , Thomas Hotz , Tobias K. S. Ritschel , Philipp Sauerteig , Karl Worthmann

We consider the problem of deciding how best to target and prioritize existing vaccines that may offer protection against new variants of an infectious disease. Sequential experiments are a promising approach; however, challenges due to…

Methodology · Statistics 2022-06-22 Han Wu , Stefan Wager

Resource support between individuals is of particular importance in controlling or mitigating epidemic spreading, especially during pandemics. Whereas there remains the question of how we can protect ourselves from being infected while…

Physics and Society · Physics 2020-02-10 Xiaolong Chen , Quanhui Liu , Ruijie Wang , Qing Li , Wei Wang