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Ultrafast electron microscopy (UEM) has found widespread applications in physics, chemistry, and materials science, enabling real-space imaging of dynamics on ultrafast timescales. Recent advances have pushed the temporal resolution of UEM…

The ability to detect and identify molecules at high sensitivity without the use of labels or capture agents is important for medical diagnostics, threat identification, environmental monitoring, and basic science. Microtoroid optical…

Optics · Physics 2022-10-17 Gwangho Choi , Adley Gin , Judith Su

Plasmonic detectors have the potential to provide a method of rapid spectroscopy without the need of moving mirrors or gratings. Previous measurements have demonstrated frequency tunable detection based on plasmonic excitations, however…

Materials Science · Physics 2015-02-09 Che Jin Bae , Deepu George , Rohit Singh , Gottfried Strasser , Andrea Markelz

Mid-infrared (MIR) imaging offers powerful capabilities for label-free chemical analysis, yet its practical deployment remains hindered by the high cost and cryogenic complexity of conventional cameras. Two-photon absorption (TPA) provides…

Optics · Physics 2026-05-25 Huijie Ma , Kun Huang , Jianan Fang , Ziyu He , Yan Liang , Heping Zeng

We report the modification of a label-free image scanning microscope (ISM) to perform asynchronous 2D imaging at 24kHz while keeping the lateral resolution gain and background rejection of a regular label-free ISM setup. Our method uses a…

Optics · Physics 2023-08-31 Duc-Minh Ta , Alberto Aguilar , Pierre Bon

Programmable electron-beam scanning offers new opportunities to improve dose efficiency and suppress scan-induced artifacts in scanning transmission electron microscopy. Here, we systematically benchmark the impact of non-raster…

Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…

Laser absorption spectroscopy (LAS) is a well-established technique for non-intrusive measurement of gas species in combustion and atmospheric environments, but conventional methods struggle with multi-species mixtures under dynamic or…

Optics · Physics 2026-05-05 Mohamed Sy

We have recently demonstrated a very favorable, inexpensive modernization of lab-based x-ray absorption fine structure (XAFS) and high-resolution x-ray emission spectroscopy (XES) using only commercially-available optics and x-ray tube…

Instrumentation and Detectors · Physics 2016-06-22 Gerald T. Seidler , Devon R. Mortensen , Alexander S. Ditter , Neil A. Ball , Adam J. Remesnik

Improving the efficiency of photothermal (PT) therapies and photoacoustic (PA) imaging at the microscopic scale hinges on developing multiphoton-absorbing photothermal molecules or contrast agents that operate in the near-infrared (NIR)…

The lensless endoscope is a promising device designed to image tissues in vivo at the cellular scale. The traditional acquisition setup consists in raster scanning during which the focused light beam from the optical fiber illuminates…

Computer Vision and Pattern Recognition · Computer Science 2018-10-31 Stéphanie Guérit , Siddharth Sivankutty , Camille Scotté , John Alto Lee , Hervé Rigneault , Laurent Jacques

High resolution image sensors require electrical access to each individual pixel for signal readout. Such access is especially challenging for ultra-miniaturized pixels, for heterogeneously integrated sensing and readout layers in…

The photon-electron interactions are generally volatile and the intricate multiphysics details of photoexcited carrier dynamics are not yet distinguished. How to nonvolatile control the physical state through all-optical means and clarify…

Optics · Physics 2024-05-02 Zhen Lei , Jiawei Chang , Qiyi Zhao , Jian Zhou , Yuanyuan Huang , Qihua Xiong , Xinlong Xu

Pump-probe microscopy enables label-free imaging of structural and chemical features of samples. However, signals in pump-probe microscopy are typically small and often must be measured in the presence of large backgrounds. As a result,…

Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample. It can infer crucial birefringence properties of bio-specimens without using any labels, thereby facilitating the diagnosis of…

A recently developed source of ultraviolet radiation, based on optical soliton propagation in a gas-filled hollow-core photonic crystal fiber, is applied here to angle-resolved photoemission spectroscopy (ARPES). Near-infrared femtosecond…

Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy as it provides several orders of magnitude higher sensitivity than inherently weak spontaneous Raman scattering by exciting localized surface plasmon…

Energy states below the bandgap of a semiconductor, such as trap states or charge transfer states in organic donor acceptor blends, can contribute to light absorption. Due to their low number density or ultrasmall absorption cross-section,…

Applied Physics · Physics 2019-11-27 Christina Kaiser , Stefan Zeiske , Paul Meredith , Ardalan Armin

The biomechanical properties of cells and tissues play an important role in our fundamental understanding of the structures and functions of biological systems at both the cellular and subcellular levels. Recently, Brillouin microscopy,…

While recent advances in reconfigurable photonics have provided new avenues for manipulating light on the subwavelength scale, on-demand control of infrared absorption remains elusive. Here, we experimentally demonstrate a plasmonic…