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Photoelectrochemical (PEC) biosensors exhibit significant potential for biomolecule detection due to their high sensitivity and low background noise. However, their performance is severely constrained by the rapid recombination of…
Cryo-electron microscopy (cryo-EM) enables the atomic-resolution visualization of biomolecules; however, modern direct detectors generate data volumes that far exceed the available storage and transfer bandwidth, thereby constraining…
The squeezed photons, as a quantum-correlated light with reduced noise, have emerged as a great resource for sensing the structures of matter. Here we study the transient absorption (TA) scheme using the squeezed photons whose spectral…
The terahertz (THz) spectral regime offers unique opportunities for next-generation biochemical sensing due to its non-destructive, label-free probing capability and strong sensitivity to molecular vibrations. However, conventional THz…
The recent development of Homochromatic Attosecond Streaking (HAS) has enabled a novel, highly precise method for ultrafast metrology of attosecond electron pulses as well as for real-time sampling of the instantaneous field waveforms of…
Photoelectron momentum microscopy is an emerging powerful method for angle-resolved photoelectron spectroscopy (ARPES), especially in combination with imaging spin filters. These instruments record kx-ky images, typically exceeding a full…
Fluorescence imaging and spectroscopy remain the most powerful tools for visualization with chemical and immunological specificity of labeled biomolecules, viruses, cellular organelles, and living cells in complex biological backgrounds.…
A laser-based angle resolved photoemission (APRES) system utilizing 6 eV photons from the fourth harmonic of a mode-locked Ti:sapphire oscillator is described. This light source greatly increases the momentum resolution and photoelectron…
Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…
Time-resolved X-ray Emission/Absorption Spectroscopy (Tr-XES/XAS) is an informative experimental tool sensitive to electronic dynamics in materials, widely exploited in diverse research fields. Typically, Tr-XES/XAS requires X-ray pulses…
Histological staining is a vital step used to diagnose various diseases and has been used for more than a century to provide contrast to tissue sections, rendering the tissue constituents visible for microscopic analysis by medical experts.…
In photoacoustic imaging, ultrasound waves generated by a temperature rise after illumination of light absorbing structures are measured on the sample surface. These measurements are then used to reconstruct the optical absorption. We…
We study the potential of graphene plasmons for spectrometer-free sensing based on surface-enhanced infrared absorption and Raman scattering. The large electrical tunability of these excitations enables an accurate identification of…
Label-free optical imaging is valuable in biology and medicine with its non-destructive property and reduced optical and chemical damages. Quantitative phase (QPI) and molecular vibrational imaging (MVI) are the two most successful…
The mesoscale characterization of biological specimens has traditionally required compromises between resolution, field-of-view, depth-of-field, and molecular specificity, with most approaches relying on external labels. Here we present the…
Microelectromechanical system (MEMS) focal plane array (FPA) with optical readout offers exciting opportunities for real-time terahertz (THz) imaging. However, conventional FPA suffers from a low THz absorption ratio, which further…
Wearable photoacoustic imaging devices hold great promise for continuous health monitoring and point-of-care diagnostics. However, the large data volume generated by high-density transducer arrays presents a major challenge for realizing…
Recording of transient absorption microscopy images requires fast detection of minute optical density changes, which is typically achieved with high-repetition-rate laser sources and lock-in detection. Here, we present a highly flexible and…
Despite inherently poor interlayer conductivity, photodetectors made from few-layer devices of 2D transition metal dichalcogenides (TMDs) such as WSe$_2$ and MoS$_2$ can still yield a desirably fast ($\leq$90 ps) and efficient…
We investigate Perfect Absorption (PA) of radiation, in which incoming energy is entirely dissipated, in a system consisting of molecular spin centers coherently coupled to a planar microwave resonator operated at milliKelvin temperature…