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Immunofluorescent (IF) imaging is crucial for visualizing biomarker expressions, cell morphology and assessing the effects of drug treatments on sub-cellular components. IF imaging needs extra staining process and often requiring cell…

Multiplex immunofluorescence (mIF) enables simultaneous single-cell quantification of multiple biomarkers within intact tissue architecture, yet its high reagent cost, multi-round staining protocols, and need for specialized imaging…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Junhyeok Lee , Han Jang , Heeseong Eum , Joon Jang , Kyu Sung Choi

While multiplex immunofluorescence (mIF) imaging provides deep, spatially-resolved molecular data, integrating this information with the morphological standard of Hematoxylin & Eosin (H&E) can be very important for obtaining complementary…

Quantitative Methods · Quantitative Biology 2025-08-08 Jillur Rahman Saurav , Mohammad Sadegh Nasr , Jacob M. Luber

Multi-focus image fusion (MFIF) addresses the depth-of-field (DOF) limitations of optical lenses, where only objects within a specific range appear sharp. Although traditional and deep learning methods have advanced the field, challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Luca Piano , Peng Huanwen , Radu Ciprian Bilcu

Advancements in digital imaging technologies have sparked increased interest in using multiplexed immunofluorescence (mIF) images to visualise and identify the interactions between specific immunophenotypes with the tumour microenvironment…

Image and Video Processing · Electrical Eng. & Systems 2024-07-01 Piumi Sandarenu , Julia Chen , Iveta Slapetova , Lois Browne , Peter H. Graham , Alexander Swarbrick , Ewan K. A. Millar , Yang Song , Erik Meijering

Cell imaging assays utilizing fluorescence stains are essential for observing sub-cellular organelles and their responses to perturbations. Immunofluorescent staining process is routinely in labs, however the recent innovations in…

Multimodal medical image fusion (MMIF) aims to integrate images from different modalities to produce a comprehensive image that enhances medical diagnosis by accurately depicting organ structures, tissue textures, and metabolic information.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Tao Luo , Weihua Xu

Multi-Focus Image Fusion (MFIF) is a promising image enhancement technique to obtain all-in-focus images meeting visual needs and it is a precondition of other computer vision tasks. One of the research trends of MFIF is to avoid the…

Computer Vision and Pattern Recognition · Computer Science 2020-11-10 Yicheng Wang , Shuang Xu , Junmin Liu , Zixiang Zhao , Chunxia Zhang , Jiangshe Zhang

Multimodal medical image fusion (MMIF) extracts the most meaningful information from multiple source images, enabling a more comprehensive and accurate diagnosis. Achieving high-quality fusion results requires a careful balance of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-19 Dan He , Weisheng Li , Guofen Wang , Yuping Huang , Shiqiang Liu

Multispectral image fusion is a computer vision process that is essential to remote sensing. For applications such as dehazing and object detection, there is a need to offer solutions that can perform in real-time on any type of scene.…

Computer Vision and Pattern Recognition · Computer Science 2023-05-09 Nati Ofir , Jean-Christophe Nebel

Multi-modality magnetic resonance imaging (MRI) is essential for the diagnosis and treatment of brain tumors. However, missing modalities are commonly observed due to limitations in scan time, scan corruption, artifacts, motion, and…

Image and Video Processing · Electrical Eng. & Systems 2025-01-08 Xiaojiao Xiao , Qinmin Vivian Hu , Guanghui Wang

Multi-modality image fusion (MMIF) combines complementary information from different image modalities to provide a comprehensive and objective interpretation of scenes. However, existing fusion methods cannot resist different weather…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Xilai Li , Wuyang Liu , Xiaosong Li , Fuqiang Zhou , Huafeng Li , Feiping Nie

Multispectral and Hyperspectral Image Fusion (MHIF) is a practical task that aims to fuse a high-resolution multispectral image (HR-MSI) and a low-resolution hyperspectral image (LR-HSI) of the same scene to obtain a high-resolution…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 ShangQi Deng , RuoCheng Wu , Liang-Jian Deng , Ran Ran , Gemine Vivone

Histological staining is a vital step used to diagnose various diseases and has been used for more than a century to provide contrast to tissue sections, rendering the tissue constituents visible for microscopic analysis by medical experts.…

Image and Video Processing · Electrical Eng. & Systems 2020-05-08 Yijie Zhang , Kevin de Haan , Yair Rivenson , Jingxi Li , Apostolos Delis , Aydogan Ozcan

Multi-modal medical images provide complementary soft-tissue characteristics that aid in the screening and diagnosis of diseases. However, limited scanning time, image corruption and various imaging protocols often result in incomplete…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Yue Zhang , Chengtao Peng , Qiuli Wang , Dan Song , Kaiyan Li , S. Kevin Zhou

Recent advancements in graph-based approaches for multiplexed immunofluorescence (mIF) images have significantly propelled the field forward, offering deeper insights into patient-level phenotyping. However, current graph-based…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Sukwon Yun , Jie Peng , Alexandro E. Trevino , Chanyoung Park , Tianlong Chen

Multi-focus image fusion technologies compress different focus depth images into an image in which most objects are in focus. However, although existing image fusion techniques, including traditional algorithms and deep learning-based…

Computer Vision and Pattern Recognition · Computer Science 2020-01-06 Xiebo Geng , Sibo Liua , Wei Han , Xu Li , Jiabo Ma , Jingya Yu , Xiuli Liu , Sahoqun Zeng , Li Chen , Shenghua Cheng

Multiplex brightfield imaging offers the advantage of simultaneously analyzing multiple biomarkers on a single slide, as opposed to single biomarker labeling on multiple consecutive slides. To accurately analyze multiple biomarkers…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Satarupa Mukherjee , Jim Martin , Yao Nie

Multi-focus image fusion aims to generate an all-in-focus image from a sequence of partially focused input images. Existing fusion algorithms generally assume that, for every spatial location in the scene, there is at least one input image…

Computer Vision and Pattern Recognition · Computer Science 2025-12-29 Xinzhe Xie , Buyu Guo , Bolin Li , Shuangyan He , Yanzhen Gu , Qingyan Jiang , Peiliang Li

Accurate and fast histological staining is crucial in histopathology, impacting diagnostic precision and reliability. Traditional staining methods are time-consuming and subjective, causing delays in diagnosis. Digital pathology plays a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-06 Marian Boktor , James E. D. Tweel , Benjamin R. Ecclestone , Jennifer Ai Ye , Paul Fieguth , Parsin Haji Reza
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