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If a binary liquid mixture, composed of two alternative species with equal amounts, is quenched from a high temperature to a low temperature, below the critical point of demixing, then the mixture will phase separate through a process known…

Statistical Mechanics · Physics 2022-02-04 Thomas J. Longo , Mikhail A. Anisimov

It has been hypothesized that liquid polyamorphism, the existence of multiple amorphous states in a single component substance, may be caused by molecular or supramolecular interconversion. A simple microscopic model [Caupin and Anisimov,…

Soft Condensed Matter · Physics 2023-09-19 Thomas J. Longo , Sergey V. Buldyrev , Mikhail A. Anisimov , Frédéric Caupin

Fluid polyamorphism is the existence of multiple fluid-fluid phase transitions in a single-component substance. It can occur due to interconversion between two alternative molecular or supramolecular states. In this work, we investigate a…

Soft Condensed Matter · Physics 2025-03-18 Mikhail A. Anisimov , Sergey V. Buldyrev , Frédéric Caupin , Thomas J. Longo

Liquid polyamorphism is the intriguing possibility for a single component substance to exist in multiple liquid phases. We propose a minimal model for this phenomenon. Starting with a binary lattice model with critical azeotropy and…

Statistical Mechanics · Physics 2023-09-19 Frédéric Caupin , Mikhaïl A. Anisimov

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

"Fluid polyamorphism" is the existence of different condensed amorphous states in a single-component fluid. It is either found or predicted, usually at extreme conditions, for a broad group of very different substances, including helium,…

A fluid composed of two molecular species may undergo phase segregation via spinodal decomposition. However, if the two molecular species can interconvert, e.g. change their chirality, then a phenomenon of phase amplification, which has not…

Statistical Mechanics · Physics 2021-06-23 Nikolay A. Shumovskyi , Thomas J. Longo , Sergey V. Buldyrev , Mikhail A. Anisimov

Liquid-liquid phase separation is key to understanding aqueous two-phase systems (ATPS) arising throughout cell biology, medical science, and the pharmaceutical industry. Controlling the detailed morphology of phase-separating compound…

Soft Condensed Matter · Physics 2023-10-27 Eric W. Hester , Sean P. Carney , Vishwesh Shah , Alyssa Arnheim , Bena Patel , Dino Di Carlo , Andrea L. Bertozzi

In active systems, whose constituents have non-equilibrium dynamics at local level, fluid-fluid phase separation is widely observed. Examples include the formation of membraneless organelles within cells; the clustering of self-propelled…

Soft Condensed Matter · Physics 2025-07-11 M. E. Cates , C. Nardini

Fluid polyamorphism, the existence of multiple amorphous fluid states in a single-component system, has been observed or predicted in a variety of substances. A remarkable example of this phenomenon is the fluid-fluid phase transition in…

Soft Condensed Matter · Physics 2022-09-21 Nathaniel R. Fried , Thomas J. Longo , Mikhail A. Anisimov

Molecules that only differ by their chirality, so called enantiomers, often possess different properties with respect to their biological function. Therefore, the separation of enantiomers presents a prominent challenge in molecular biology…

Soft Condensed Matter · Physics 2009-11-11 Marcin Kostur , Michael Schindler , Peter Talkner , Peter Hänggi

Liquid-liquid phase separation is the mechanism underlying the formation of biomolecular condensates. Disordered protein regions often drive phase separation, but molecular interactions of disordered protein regions are not well understood,…

Biomolecules · Quantitative Biology 2020-08-10 Wade Borcherds , Anne Bremer , Madeleine B. Borgia , Tanja Mittag

We study a model chiral fluid in two dimensions composed of Brownian disks interacting via a Lennard-Jones potential and a non-conservative transverse force, mimicking colloids spinning at a rate $\omega$. The system exhibits a phase…

Soft Condensed Matter · Physics 2023-07-10 Claudio B. Caporusso , Giuseppe Gonnella , Demian Levis

We study phase separation between coexisting active and passive fluids in three-dimensions, using numerical simulation and experiments. Chaotic flows of the active phase drive giant interfacial deformations, causing the co-existing phases…

Soft Condensed Matter · Physics 2026-02-16 Paarth Gulati , Liang Zhao , Michio Tateno , Omar A. Saleh , Zvonimir Dogic , M. Cristina Marchetti

Active phase separations evade canonical thermodynamic descriptions and have thus challenged our understanding of coexistence and interfacial phenomena. Considerable progress has been made towards a non-equilibrium theoretical description…

Soft Condensed Matter · Physics 2025-04-21 Luke Langford , Ahmad K. Omar

Fluid mixtures, such as the cellular cytoplasm and synthetic DNA nanostars, can spontaneously compartmentalize into many coexisting phases through liquid-liquid phase separation. Despite the diversity of fluid structures that emerge from…

Fluid Dynamics · Physics 2026-03-05 Michael Rennick , Xitong Zhang , Halim Kusumaatmaja

We deduce the mixing-demixing phase diagram for binary liquid mixtures in an electric field for various electrode geometries and arbitrary constitutive relation for the dielectric constant. By focusing on the behavior of the liquid-liquid…

Soft Condensed Matter · Physics 2013-07-18 Jennifer Galanis , Yoav Tsori

The separation of substances into different phases is ubiquitous in nature and important scientifically and technologically. This phenomenon may become drastically different if the species involved, whether molecules or supramolecular…

We use numerical simulation to examine the possibility of a reversible liquid-liquid transition in supercooled water and related systems. In particular, for two atomistic models of water, we have computed free energies as functions of…

Statistical Mechanics · Physics 2012-05-11 David T. Limmer , David Chandler

We propose a model describing the phase behavior of two-component membranes consisting of binary mixtures of electrically charged and neutral lipids. We take into account the structural phase transition (main-transition) of the hydrocarbon…

Soft Condensed Matter · Physics 2016-07-11 Naofumi Shimokawa , Hiroki Himeno , Tsutomu Hamada , Masahiro Takagi , Shigeyuki Komura , David Andelman
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