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Domain generalization (DG), aiming at models able to work on multiple unseen domains, is a must-have characteristic of general artificial intelligence. DG based on single source domain training data is more challenging due to the lack of…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Qingyue Yang , Hongjing Niu , Pengfei Xia , Wei Zhang , Bin Li

Domain generalization (DG) is a prevalent problem in real-world applications, which aims to train well-generalized models for unseen target domains by utilizing several source domains. Since domain labels, i.e., which domain each data point…

Machine Learning · Computer Science 2023-11-14 Yunze Tong , Junkun Yuan , Min Zhang , Didi Zhu , Keli Zhang , Fei Wu , Kun Kuang

Machine learning typically relies on the assumption that training and testing distributions are identical and that data is centrally stored for training and testing. However, in real-world scenarios, distributions may differ significantly…

Machine Learning · Computer Science 2025-08-22 Ying Li , Xingwei Wang , Rongfei Zeng , Praveen Kumar Donta , Ilir Murturi , Min Huang , Schahram Dustdar

Fine-grained domain generalization (FGDG) aims to learn a fine-grained representation that can be well generalized to unseen target domains when only trained on the source domain data. Compared with generic domain generalization, FGDG is…

Computer Vision and Pattern Recognition · Computer Science 2025-04-14 Qi Bi , Jingjun Yi , Haolan Zhan , Wei Ji , Gui-Song Xia

Robust generalization beyond training distributions remains a critical challenge for deep neural networks. This is especially pronounced in medical image analysis, where data is often scarce and covariate shifts arise from different…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Francesco Di Salvo , Sebastian Doerrich , Jonas Alle , Christian Ledig

Efficient medical image segmentation aims to provide accurate pixel-wise predictions for medical images with a lightweight implementation framework. However, lightweight frameworks generally fail to achieve superior performance and suffer…

Computer Vision and Pattern Recognition · Computer Science 2023-02-21 Xingqun Qi , Zhuojie Wu , Min Ren , Muyi Sun , Caifeng Shan , Zhenan Sun

Domain generalization (DG) aims to learn predictive models that can generalize to unseen domains. Most existing DG approaches focus on learning domain-invariant representations under the assumption of conditional distribution shift (i.e.,…

Machine Learning · Computer Science 2026-02-03 Jewon Yeom , Kyubyung Chae , Hyunggyu Lim , Yoonna Oh , Dongyoon Yang , Taesup Kim

Medical data often exhibits distribution shifts, which cause test-time performance degradation for deep learning models trained using standard supervised learning pipelines. This challenge is addressed in the field of Domain Generalization…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Aleksandr Matsun , Numan Saeed , Fadillah Adamsyah Maani , Mohammad Yaqub

Due to domain shifts, machine learning systems typically struggle to generalize well to new domains that differ from those of training data, which is what domain generalization (DG) aims to address. Although a variety of DG methods have…

Machine Learning · Computer Science 2023-11-15 Jingang Qu , Thibault Faney , Ze Wang , Patrick Gallinari , Soleiman Yousef , Jean-Charles de Hemptinne

We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply it to a different domain (e.g., MR) without adapting the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Franz Thaler , Martin Urschler , Mateusz Kozinski , Matthias AF Gsell , Gernot Plank , Darko Stern

Domain generalization (DG) is a fundamental yet very challenging research topic in machine learning. The existing arts mainly focus on learning domain-invariant features with limited source domains in a static model. Unfortunately, there is…

Machine Learning · Computer Science 2022-05-30 Zhishu Sun , Zhifeng Shen , Luojun Lin , Yuanlong Yu , Zhifeng Yang , Shicai Yang , Weijie Chen

An organ segmentation method that can generalize to unseen contrasts and scanner settings can significantly reduce the need for retraining of deep learning models. Domain Generalization (DG) aims to achieve this goal. However, most DG…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Yanwu Xu , Shaoan Xie , Maxwell Reynolds , Matthew Ragoza , Mingming Gong , Kayhan Batmanghelich

Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Chenxin Li , Qi Qi , Xinghao Ding , Yue Huang , Dong Liang , Yizhou Yu

Though convolutional neural networks are widely used in different tasks, lack of generalization capability in the absence of sufficient and representative data is one of the challenges that hinder their practical application. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2021-07-07 Yufei Wang , Haoliang Li , Lap-pui Chau , Alex C. Kot

Deep learning models often encounter challenges in making accurate inferences when there are domain shifts between the source and target data. This issue is particularly pronounced in clinical settings due to the scarcity of annotated data…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Heng Li , Haojin Li , Jianyu Chen , Mingyang Ou , Hai Shu , Heng Miao

Domain generalisation (DG) methods address the problem of domain shift, when there is a mismatch between the distributions of training and target domains. Data augmentation approaches have emerged as a promising alternative for DG. However,…

Machine Learning · Computer Science 2020-12-29 Hoang Son Le , Rini Akmeliawati , Gustavo Carneiro

Domain Generalization (DG) aims to learn models whose performance remains high on unseen domains encountered at test-time by using data from multiple related source domains. Many existing DG algorithms reduce the divergence between source…

Machine Learning · Computer Science 2022-06-27 Akshay Mehra , Bhavya Kailkhura , Pin-Yu Chen , Jihun Hamm

The absence of well-structured large datasets in medical computer vision results in decreased performance of automated systems and, especially, of deep learning models. Domain generalization techniques aim to approach unknown domains from a…

Image and Video Processing · Electrical Eng. & Systems 2024-06-04 Nikolaos Spanos , Anastasios Arsenos , Paraskevi-Antonia Theofilou , Paraskevi Tzouveli , Athanasios Voulodimos , Stefanos Kollias

The vast amount of health data has been continuously collected for each patient, providing opportunities to support diverse healthcare predictive tasks such as seizure detection and hospitalization prediction. Existing models are mostly…

Machine Learning · Computer Science 2023-02-16 Chaoqi Yang , M. Brandon Westover , Jimeng Sun

Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Zhenye Lou , Qing Xu , Zekun Jiang , Xiangjian He , Zhen Chen , Yi Wang , Chenxin Li , Maggie M. He , Wenting Duan