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Certain biochemical reactions can only be triggered after binding of a sufficient number of particles to a specific target region such as an enzyme or a protein sensor. We investigate the distribution of the reaction time, i.e., the first…

Chemical Physics · Physics 2022-10-10 Denis S. Grebenkov , Aanjaneya Kumar

We present a stochastic lattice theory describing the kinetic behavior of trapping reactions $A + B \to B$, in which both the $A$ and $B$ particles perform an independent stochastic motion on a regular hypercubic lattice. Upon an encounter…

Statistical Mechanics · Physics 2009-11-10 M. Moreau , G. Oshanin , O. Benichou , M. Coppey

We re-visit the problem of two (oppositely) charged particles interacting electromagnetically in one dimension with retarded potentials and no radiation reaction. The specific quantitative result of interest is the time it takes for the…

Classical Physics · Physics 2013-10-22 J. Franklin , C. LaMont

In biochemical reaction networks, the first passage time (FPT) of a reaction quantifies the time it takes for the reaction to first occur, from the initial state. While the mean FPT historically served as a summary metric, a far more…

Molecular Networks · Quantitative Biology 2025-03-07 Changqian Rao , David Waxman , Wei Lin , Zhuoyi Song

We study the efficiency of a two-channel reaction between two walkers on a finite one-dimensional periodic lattice. The walkers perform a combination of synchronous and asynchronous jumps on the lattice and react instantaneously when they…

Statistical Mechanics · Physics 2007-05-23 E. Abad

Complex systems often have features that can be modeled by advanced mathematical tools [1]. Of special interests are the features of complex systems that have a network structure as such systems are important for modeling technological and…

Classical Physics · Physics 2019-06-13 Nikolay K. Vitanov , Kaloyan N. Vitanov , Zlatinka I. Dimitrova

We study a system of diffusing point particles in which any triplet of particles reacts and is removed from the system when the relative proximity of the constituent particles satisfies a predefined condition. Proximity-based reaction…

Numerical Analysis · Mathematics 2025-04-07 Taylor Kearney , Ricardo Ruiz-Baier , Mark B. Flegg

We study diffusion-reaction processes on periodic square planar lattices and simple cubic (sc) lattices. Considered first is a single diffusing reactant undergoing an irreversible reaction upon first encounter with a stationary co-reactant…

Statistical Mechanics · Physics 2018-08-22 E. Abad , T. Abil , A. Santos , J. J. Kozak

We study the effect of confinement on diffusion limited bimolecular reactions within a lattice model where a small number of reactants diffuse amongst a much larger number of inert particles. When the number of inert particles is held…

Soft Condensed Matter · Physics 2013-05-29 Jeremy D. Schmit , Ercan Kamber , Jané Kondev

We investigate a class of diffusion-controlled reactions that are initiated at the time instance when a prescribed number $K$ among $N$ particles independently diffusing in a solvent are simultaneously bound to a target region. In the…

Chemical Physics · Physics 2023-10-17 Denis S. Grebenkov , Aanjaneya Kumar

It has long been appreciated that transport properties can control reaction kinetics. This effect can be characterized by the time it takes a diffusing molecule to reach a target -- the first-passage time (FPT). Although essential to…

Statistical Mechanics · Physics 2015-05-19 O. Bénichou , C. Chevalier , J. Klafter , B. Meyer , R. Voituriez

We explore theoretically the navigation of an active particle based on delayed feedback control. The delayed feedback enters in our expression for the particle orientation which, for an active particle, determines (up to noise) the…

Statistical Mechanics · Physics 2019-07-24 S. M. J. Khadem , Sabine H. L. Klapp

In this paper, we revisit the problem of classical \textit{meeting times} of random walks in graphs. In the process that two tokens (called agents) perform random walks on an undirected graph, the meeting times are defined as the expected…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-05-22 Ryota Eguchi , Fukuhito Ooshita , Michiko Inoue , Sébastien Tixeuil

We investigate the effects of spatial discreteness of molecules in reaction-diffusion systems. It is found that discreteness within the so called Kuramoto length can lead to a localization of molecules, resulting in novel steady states that…

Chemical Physics · Physics 2007-05-23 Yuichi Togashi , Kunihiko Kaneko

The interactions between diffusing molecules and membrane-bound receptors drive numerous cellular processes. In this work, we develop a spatial model of molecular interactions with membrane receptors by homogenizing the cell membrane and…

Quantitative Methods · Quantitative Biology 2025-01-24 Anil Cengiz , Sean D Lawley

In spatially distributed cellular systems, it is often convenient to represent complicated auxiliary pathways and spatial transport by time-delayed reaction rates. Furthermore, many of the reactants appear in low numbers necessitating a…

Quantitative Methods · Quantitative Biology 2015-05-14 Matthew Scott

In most natural sciences there is currently the insight that it is necessary to bridge gaps between different processes which can be observed on different scales. This is especially true in the field of chemical reactions where the…

Molecular Networks · Quantitative Biology 2008-03-03 L. Sbano , M. Kirkilionis

The first-passage time (FPT), i.e., the moment when a stochastic process reaches a given threshold value for the first time, is a fundamental mathematical concept with immediate applications. In particular, it quantifies the statistics of…

Subcellular Processes · Quantitative Biology 2018-12-05 Denis S. Grebenkov , Ralf Metzler , Gleb Oshanin

In this work we study a kinetic model of active particles with delayed dynamics, and its limit when the number of particles goes to infinity. This limit turns out to be related to delayed differential equations with random initial…

Analysis of PDEs · Mathematics 2020-06-17 Juan Pablo Pinasco , Mauro Rodriguez Cartabia , Nicolas Saintier

Universal intermittent dynamics in a random catalytic reaction network, induced by smallness in the molecule number is reported. Stochastic simulations for a random catalytic reaction network subject to a flow of chemicals show that the…

Statistical Mechanics · Physics 2009-02-20 Akinori Awazu , Kunihiko Kaneko