Related papers: Interactive Treatment Planning in High Dose-Rate B…
This study investigates the applicability of 3D dose predictions from a model trained on one modality to a cross-modality automated planning workflow. Additionally, we explore the impact of integrating a multi-criteria optimizer on adapting…
Inverse optimization (IO) algorithms are used in GYN HDR brachytherapy planning, with user parameter settings embedded in commercial TPS. To examine the dosimetric influence of hidden input parameters in three IO algorithms-IPSA, HIPO, and…
In 2010, gynecologic malignancies were the 4th leading cause of death in U.S. women and for patients with extensive primary or recurrent disease, treatment with interstitial brachytherapy may be an option. However, brachytherapy requires…
Online adaptive radiation therapy (ART) has great promise to significantly reduce normal tissue toxicity and/or improve tumor control through real-time treatment adaptations based on the current patient anatomy. However, the major technical…
To accurately verify the dose of intensity-modulated radiation therapy (IMRT), we have used a global optimization method to investigate a new dose-verification algorithm. In practical application of this quality assurance (QA) procedure,…
This study presents FREDopt, a newly developed GPU-accelerated open-source optimization software for simultaneous proton dose and dose-averaged LET (LETd) optimization in IMPT treatment planning. FREDopt was implemented entirely in Python,…
Constrained convex optimization problems arise naturally in many real-world applications. One strategy to solve them in an approximate way is to translate them into a sequence of convex feasibility problems via the recently developed level…
The problem of chemotherapy treatment optimization can be defined in order to minimize the size of the tumor without endangering the patient's health; therefore, chemotherapy requires to achieve a number of objectives, simultaneously. For…
The challenge of removing cancerous cells lies in the limitation of organ at risk, which restricts the ability to increase the radiation dose adequately for enhancing treatment effectiveness. This survey provides a comprehensive overview of…
We developed a novel method of creating intensity modulated proton arc therapy (IMPAT) plans that uses computing resources efficiently and may offer a dosimetric benefit for patients with ependymoma or similar tumor geometries. Our IMPAT…
Robust treatment planning algorithms for Intensity Modulated Proton Therapy (IMPT) and Intensity Modulated Radiation Therapy (IMRT) allow for uncertainty reduction in the delivered dose distributions through explicit inclusion of error…
Multicriteria optimization problems occur in many real life applications, for example in cancer radiotherapy treatment and in particular in intensity modulated radiation therapy (IMRT). In this work we focus on optimization problems with…
Background: Radiotherapy treatment planning involves solving large-scale optimization problems that are often approximated and solved sub-optimally due to time constraints. Central to these problems is the dose influence matrix which…
Chemotherapy is one of the primary modalities of cancer treatment. Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens. One way to alleviate this burden and…
Volumetric modulated arc therapy planning is a challenging problem in high-dimensional, non-convex optimization. Traditionally, heuristics such as fluence-map-optimization-informed segment initialization use locally optimal solutions to…
German text, english abstract: Mortality in gynecologic cancers, including cervical, ovarian, vaginal and vulvar cancers, is more than 6% internationally [1]. In many countries external radiotherapy is supplemented by brachytherapy with…
Multi-objective optimisation using BRIGHT has proven insightful and effective in prostate cancer brachytherapy treatment planning. BRachytherapy via artificially Intelligent GOMEA-Heuristic based Treatment planning (BRIGHT) generates…
This study presents the development and validation of an independent software tool based on the Varian Eclipse Scripting API (ESAPI) for multi-modal brachytherapy Quality Assurance (QA). The tool addresses GEC-ESTRO HDR protocols and LDR…
We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a…
Lattice radiotherapy (LATTICE) is a form of spatially fractionated radiation therapy (SFRT) designed to deliver high doses to tumor regions while sparing surrounding tissues. Traditional LATTICE uses rigid vertex patterns, limiting…