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Causal machine learning tools are beginning to see use in real-world policy evaluation tasks to flexibly estimate treatment effects. One issue with these methods is that the machine learning models used are generally black boxes, i.e.,…

Machine Learning · Computer Science 2024-04-01 Patrick Rehill , Nicholas Biddle

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

Machine learning (ML) is increasingly being used in image retrieval systems for medical decision making. One application of ML is to retrieve visually similar medical images from past patients (e.g. tissue from biopsies) to reference when…

Deep Learning is a state-of-the-art technique to make inference on extensive or complex data. As a black box model due to their multilayer nonlinear structure, Deep Neural Networks are often criticized to be non-transparent and their…

Artificial Intelligence · Computer Science 2019-11-28 Vanessa Buhrmester , David Münch , Michael Arens

Healthcare clinics regularly encounter dynamic data that changes due to variations in patient populations, treatment policies, medical devices, and emerging disease patterns. Deep learning models can suffer from catastrophic forgetting when…

Machine Learning · Computer Science 2023-11-09 Amritpal Singh , Mustafa Burak Gurbuz , Shiva Souhith Gantha , Prahlad Jasti

Deep learning-based recognition systems are deployed at scale for several real-world applications that inevitably involve our social life. Although being of great support when making complex decisions, they might capture spurious data…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Leonardo Iurada , Silvia Bucci , Timothy M. Hospedales , Tatiana Tommasi

There is a rich and growing literature on producing local contrastive/counterfactual explanations for black-box models (e.g. neural networks). In these methods, for an input, an explanation is in the form of a contrast point differing in…

Machine Learning · Computer Science 2020-10-30 Tejaswini Pedapati , Avinash Balakrishnan , Karthikeyan Shanmugam , Amit Dhurandhar

While interest in the application of machine learning to improve healthcare has grown tremendously in recent years, a number of barriers prevent deployment in medical practice. A notable concern is the potential to exacerbate entrenched…

Machine Learning · Computer Science 2022-05-19 Isabel Chien , Nina Deliu , Richard E. Turner , Adrian Weller , Sofia S. Villar , Niki Kilbertus

Many applications of machine learning methods involve an iterative protocol in which data are collected, a model is trained, and then outputs of that model are used to choose what data to consider next. For example, one data-driven approach…

Machine Learning · Computer Science 2025-04-07 Clara Fannjiang , Stephen Bates , Anastasios N. Angelopoulos , Jennifer Listgarten , Michael I. Jordan

Conformal predictors are an important class of algorithms that allow predictions to be made with a user-defined confidence level. They are able to do this by outputting prediction sets, rather than simple point predictions. The conformal…

Machine Learning · Computer Science 2021-05-25 Anthony Bellotti

Deep learning models achieve high predictive performance but lack intrinsic interpretability, hindering our understanding of the learned prediction behavior. Existing local explainability methods focus on associations, neglecting the causal…

Machine Learning · Computer Science 2025-09-18 Niklas Penzel , Joachim Denzler

The deployment of vision-language models (VLMs) in dermatology is hindered by the trilemma of high computational costs, extreme data scarcity, and the black-box nature of deep learning. To address these challenges, we present SkinCLIP-VL, a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Zhixiang Lu , Shijie Xu , Kaicheng Yan , Xuyue Cai , Chong Zhang , Yulong Li , Angelos Stefanidis , Anh Nguyen , Jionglong Su

As deep learning (DL) continues to demonstrate its ability in radiological tasks, it is critical that we optimize clinical DL solutions to include safety. One of the principal concerns in the clinical adoption of DL tools is trust. This…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Cooper Gamble , Shahriar Faghani , Bradley J. Erickson

Deep learning models for dermatological image analysis remain sensitive to acquisition variability and domain-specific visual characteristics, leading to performance degradation when deployed in clinical settings. We investigate how visual…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Rodrigo Mota , Kelvin Cunha , Emanoel dos Santos , Fábio Papais , Francisco Filho , Thales Bezerra , Erico Medeiros , Paulo Borba , Tsang Ing Ren

To plan safe maneuvers and act with foresight, autonomous vehicles must be capable of accurately predicting the uncertain future. In the context of autonomous driving, deep neural networks have been successfully applied to learning…

Robotics · Computer Science 2022-08-02 Salar Arbabi , Davide Tavernini , Saber Fallah , Richard Bowden

Many clinical deep learning algorithms are population-based and difficult to interpret. Such properties limit their clinical utility as population-based findings may not generalize to individual patients and physicians are reluctant to…

Signal Processing · Electrical Eng. & Systems 2020-12-01 Dani Kiyasseh , Tingting Zhu , David A. Clifton

In clinical practice, decision-making relies heavily on established protocols, often formalised as rules. Concurrently, Machine Learning (ML) models, trained on clinical data, aspire to integrate into medical decision-making processes.…

Artificial Intelligence · Computer Science 2024-11-06 Christel Sirocchi , Muhammad Suffian , Federico Sabbatini , Alessandro Bogliolo , Sara Montagna

Clinical machine learning applications are often plagued with confounders that can impact the generalizability and predictive performance of the learners. Confounding is especially problematic in remote digital health studies where the…

Last years have been characterized by an upsurge of opaque automatic decision support systems, such as Deep Neural Networks (DNNs). Although they have great generalization and prediction skills, their functioning does not allow obtaining…

Conformal prediction is a model-agnostic approach to generating prediction sets that cover the true class with a high probability. Although its prediction set size is expected to capture aleatoric uncertainty, there is a lack of evidence…

Machine Learning · Computer Science 2025-11-24 Misgina Tsighe Hagos , Claes Lundström