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Breast cancer is the most common cancers and early detection from mammography screening is crucial in improving patient outcomes. Assessing mammographic breast density is clinically important as the denser breasts have higher risk and are…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Charles Lu , Ken Chang , Praveer Singh , Jayashree Kalpathy-Cramer

Reliable uncertainty estimation is one of the major challenges for medical classification tasks. While many approaches have been proposed, recently the statistical framework of conformal predictions has gained a lot of attention, due to its…

Machine Learning · Computer Science 2025-06-24 Hendrik Mehrtens , Tabea Bucher , Titus J. Brinker

Background and objective: Uncertainty quantification is a pivotal field that contributes to realizing reliable and robust systems. It becomes instrumental in fortifying safe decisions by providing complementary information, particularly…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Jamil Fayyad , Shadi Alijani , Homayoun Najjaran

Deep learning methods have been very effective for a variety of medical diagnostic tasks and has even beaten human experts on some of those. However, the black-box nature of the algorithms has restricted clinical use. Recent explainability…

Computer Vision and Pattern Recognition · Computer Science 2020-05-29 Amitojdeep Singh , Sourya Sengupta , Vasudevan Lakshminarayanan

Deep learning based diagnostic AI systems based on medical images are starting to provide similar performance as human experts. However these data hungry complex systems are inherently black boxes and therefore slow to be adopted for high…

Machine Learning · Computer Science 2025-04-01 Swarnava Bhattacharyya , Umapada Pal , Tapabrata Chakraborti

Conformal prediction is widely used to equip black-box machine learning models with uncertainty quantification, offering formal coverage guarantees under exchangeable data. However, these guarantees fail when faced with subpopulation…

Machine Learning · Computer Science 2025-11-10 Nien-Shao Wang , Duygu Nur Yaldiz , Yavuz Faruk Bakman , Sai Praneeth Karimireddy

Black-box machine learning models are now routinely used in high-risk settings, like medical diagnostics, which demand uncertainty quantification to avoid consequential model failures. Conformal prediction is a user-friendly paradigm for…

Machine Learning · Computer Science 2022-12-08 Anastasios N. Angelopoulos , Stephen Bates

Interest has been growing in decision-focused machine learning methods which train models to account for how their predictions are used in downstream optimization problems. Doing so can often improve performance on subsequent decision…

Machine Learning · Computer Science 2025-03-03 Santiago Cortes-Gomez , Carlos Patiño , Yewon Byun , Steven Wu , Eric Horvitz , Bryan Wilder

Although deep learning prediction models have been successful in the discrimination of different classes, they can often suffer from poor calibration across challenging domains including healthcare. Moreover, the long-tail distribution…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Riqiang Gao , Thomas Li , Yucheng Tang , Zhoubing Xu , Michael Kammer , Sanja L. Antic , Kim Sandler , Fabien Moldonado , Thomas A. Lasko , Bennett Landman

Medical imaging classifiers can achieve high predictive accuracy, but quantifying their uncertainty remains an unresolved challenge, which prevents their deployment in medical clinics. We present an algorithm that can modify any classifier…

Machine Learning · Computer Science 2024-08-12 Roy Hirsch , Jacob Goldberger

In this work, we study some novel applications of conformal inference techniques to the problem of providing machine learning procedures with more transparent, accurate, and practical performance guarantees. We provide a natural extension…

Machine Learning · Statistics 2020-07-10 Matthew J. Holland

With the current ongoing debate about fairness, explainability and transparency of machine learning models, their application in high-impact clinical decision-making systems must be scrutinized. We consider a real-life example of risk…

Machine Learning · Computer Science 2020-11-13 Sandhya Tripathi , Bradley A. Fritz , Mohamed Abdelhack , Michael S. Avidan , Yixin Chen , Christopher R. King

The use of AI systems in healthcare for the early screening of diseases is of great clinical importance. Deep learning has shown great promise in medical imaging, but the reliability and trustworthiness of AI systems limit their deployment…

Image and Video Processing · Electrical Eng. & Systems 2023-05-17 Ke Zou , Zhihao Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Chenglong Wang , Yinqiao Yi , Yida Wang , Chengxiu Zhang , Yun Liu , Kensaku Mori , Mei Yuan , Guang Yang

Multimodal deep learning has been used to predict clinical endpoints and diagnoses from clinical routine data. However, these models suffer from scaling issues: they have to learn pairwise interactions between each piece of information in…

As deep neural networks are more commonly deployed in high-stakes domains, their black-box nature makes uncertainty quantification challenging. We investigate the presentation of conformal prediction sets--a distribution-free class of…

Human-Computer Interaction · Computer Science 2024-04-29 Dongping Zhang , Angelos Chatzimparmpas , Negar Kamali , Jessica Hullman

In recent years the development of artificial intelligence (AI) systems for automated medical image analysis has gained enormous momentum. At the same time, a large body of work has shown that AI systems can systematically and unfairly…

Image and Video Processing · Electrical Eng. & Systems 2023-05-10 María Agustina Ricci Lara , Candelaria Mosquera , Enzo Ferrante , Rodrigo Echeveste

Deep learning based cervical cancer classification can potentially increase access to screening in low-resource regions. However, deep learning models are often overconfident and do not reliably reflect diagnostic uncertainty. Moreover,…

Image and Video Processing · Electrical Eng. & Systems 2025-05-15 Misgina Tsighe Hagos , Antti Suutala , Dmitrii Bychkov , Hakan Kücükel , Joar von Bahr , Milda Poceviciute , Johan Lundin , Nina Linder , Claes Lundström

Although deep learning (DL) models have shown great success in many medical image analysis tasks, deployment of the resulting models into real clinical contexts requires: (1) that they exhibit robustness and fairness across different…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Raghav Mehta , Changjian Shui , Tal Arbel

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin
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