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Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on the power…

Populations and Evolution · Quantitative Biology 2021-05-21 Rob Johnson , Chris Jackson , Anne Presanis , Sofia S. Villar , Daniela De Angelis

Massive vaccination against pandemics such as Coronavirus SARS-CoV-2 presents several complexities. The criteria to assess public health policies are fundamental to distribute vaccines in an effective way in order to avoid as many…

Optimization and Control · Mathematics 2023-12-01 José Luis Sainz-Pardo , José Valero

Spreading processes represent a very efficient tool to investigate the structural properties of networks and the relative importance of their constituents, and have been widely used to this aim in static networks. Here we consider simple…

Physics and Society · Physics 2013-09-11 Michele Starnini , Anna Machens , Ciro Cattuto , Alain Barrat , Romualdo Pastor Satorras

We develop a general framework for reserve systems that allocate scarce resources such as vaccines to unit-demand agents under prioritization and eligibility constraints, along with a computationally efficient mechanism. Reserve systems…

Theoretical Economics · Economics 2025-11-25 Suat Evren

When facing an extreme stressor, such as the COVID-19 pandemic, healthcare systems typically respond reactively by creating surge capacity at facilities that are at or approaching their baseline capacity. However, creating individual…

Optimization and Control · Mathematics 2020-11-09 Felix Parker , Hamilton Sawczuk , Fardin Ganjkhanloo , Farzin Ahmadi , Kimia Ghobadi

Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in…

Populations and Evolution · Quantitative Biology 2016-03-29 Chantal Nguyen , Jean M. Carlson

Developing robust, quantitative methods to optimize resource allocations in response to epidemics has the potential to save lives and minimize health care costs. In this paper, we develop and apply a computationally efficient algorithm that…

Quantitative Methods · Quantitative Biology 2015-06-22 Edwin C. Yuan , David L. Alderson , Sean Stromberg , Jean M. Carlson

Since the recent introduction of several viable vaccines for SARS-CoV-2, vaccination uptake has become the key factor that will determine our success in containing the COVID-19 pandemic. We argue that game theory and social network models…

Background: Network-based interventions are most powerful against epidemics when the full network structure is known. However, resource constraints often require decisions based on partial network data. We investigated how the effectiveness…

Populations and Evolution · Quantitative Biology 2018-03-30 Yingrui Yang , Ashley McKhann , Guy Harling , Jukka-Pekka Onnela

The effectiveness of vaccination highly depends on the choice of individuals to vaccinate, even if the same number of individuals are vaccinated. Vaccinating individuals with high centrality measures such as betweenness centrality (BC) and…

Physics and Society · Physics 2021-12-30 Bukyoung Jhun

Efficient testing and vaccination protocols are critical aspects of epidemic management. To study the optimal allocation of limited testing and vaccination resources in a heterogeneous contact network of interacting susceptible, recovered,…

Populations and Evolution · Quantitative Biology 2026-05-12 Mingtao Xia , Lucas Böttcher , Tom Chou

We focus on the problem of uncertainty informed allocation of medical resources (vaccines) to heterogeneous populations for managing epidemic spread. We tackle two related questions: (1) For a compartmental ordinary differential equation…

Optimization and Control · Mathematics 2023-07-04 Samarth Gupta , Saurabh Amin

During the Covid-19 pandemic a key role is played by vaccination to combat the virus. There are many possible policies for prioritizing vaccines, and different criteria for optimization: minimize death, time to herd immunity, functioning of…

Populations and Evolution · Quantitative Biology 2022-03-18 Qi Luo , Ryan Weightman , Sean T. McQuade , Mateo Diaz , Emmanuel Trélat , William Barbour , Dan Work , Samitha Samaranayake , Benedetto Piccoli

Considering the global pandemic of coronavirus disease 2019 (COVID-19), around the world several vaccines are being developed. Till now, these vaccines are the most effective way to reduce the high burden on the global health…

Physics and Society · Physics 2023-02-22 Dibyajyoti Mallick , Aniruddha Ray , Ankita Das , Sayantari Ghosh

In a world being hit by waves of COVID-19, vaccination is a light on the horizon. However, the roll-out of vaccination strategies and their influence on the pandemic are still open problems. In order to compare the effect of various…

Physics and Society · Physics 2021-04-23 N. L. Barreiro , C. I. Ventura , T. Govezensky , M. Núñez , P. G. Bolcatto , R. A. Barrio

We study vaccine budget-sharing strategies in the SIR (Susceptible-Infected-Recovered) model given a structured community network to investigate the benefit of sharing vaccine across communities. The network studied comprises two…

Physics and Society · Physics 2023-11-14 Felippe Alves , David Saad

How to ensure accessibility to food and nutrition while food supply chains suffer from demand and supply uncertainties caused by disruptive forces such as the COVID-19 pandemic and natural disasters is an emerging and critical issue.…

General Economics · Economics 2024-06-14 Mengfei Chen , Mohamed Kharbeche , Mohamed Haouari , Weihong "Grace" Guo

This study presents a new risk-averse multi-stage stochastic epidemics-ventilator-logistics compartmental model to address the resource allocation challenges of mitigating COVID-19. This epidemiological logistics model involves the…

Applications · Statistics 2021-03-12 Xuecheng Yin , I. Esra Buyuktahtakin , Bhumi P. Patel

The aftermath of the Covid-19 pandemic saw more severe outcomes for racial minority groups and economically-deprived communities. Such disparities can be explained by several factors, including unequal access to healthcare, as well as the…

Computers and Society · Computer Science 2024-03-12 Nicola Neophytou , Afaf Taïk , Golnoosh Farnadi

How to allocate vaccines over heterogeneous individuals is one of the important policy decisions in pandemic times. This paper develops a procedure to estimate an individualized vaccine allocation policy under limited supply, exploiting…

Econometrics · Economics 2021-10-25 Toru Kitagawa , Guanyi Wang