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The impact of spatial structure on the spread of an epidemic is an important issue in the propagation of infectious diseases. Recent studies, both deterministic and stochastic, have made it possible to understand the importance of the…

Probability · Mathematics 2023-01-09 Alphonse Emakoua

We propose a numerical method for approximating integro-differential equations arising in age-of-infection epidemic models. The method is based on a non-standard finite differences approximation of the integral term appearing in the…

Numerical Analysis · Mathematics 2024-07-22 Eleonora Messina , Mario Pezzella , Antonia Vecchio

The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary case…

Quantitative Methods · Quantitative Biology 2025-01-23 Hannah Craddock , Simon EF Spencer , Xavier Didelot

Recently, research that focuses on the rigorous understanding of the relation between simulation and/or exact models on graphs and approximate counterparts has gained lots of momentum. This includes revisiting the performance of classic…

Dynamical Systems · Mathematics 2011-10-18 Istvan Z. Kiss , Péter L. Simon

We present an analysis of six deterministic models for epidemic spreading. The evolution of the number of individuals of each class is given by ordinary differential equations of the first order in time, which are set up by using the laws…

Biological Physics · Physics 2020-12-25 Tânia Tomé , Mário J. de Oliveira

Partial differential equation (PDE) models for infectious diseases, while less common than their ordinary differential equation (ODE) counterparts, have found successful applications for many years. Such models are typically of…

Populations and Evolution · Quantitative Biology 2026-01-27 Alex Viguerie , Malú Grave , Alvaro L. G. A. Coutinho , Alessandro Veneziani , Thomas J. R. Hughes

Understanding interactions between the spread of multiple pathogens during an epidemic is crucial to assessing the severity of infections in human communities. In this paper, we introduce two new Multiplex Bi-Virus Reaction-Diffusion models…

Physics and Society · Physics 2025-08-22 Alyssa Yu , Laura P. Schaposnik

The dynamics of epidemic spreading is often reduced to the single control parameter $R_0$, whose value, above or below unity, determines the state of the contagion. If, however, the pathogen evolves as it spreads, $R_0$ may change over…

Populations and Evolution · Quantitative Biology 2022-11-07 Xiyun Zhang , Zhongyuan Ruan , Muhua Zheng , Jie Zhou , Stefano Boccaletti , Baruch Barzel

We propose a penalized likelihood method to fit the bivariate categorical response regression model. Our method allows practitioners to estimate which predictors are irrelevant, which predictors only affect the marginal distributions of the…

Methodology · Statistics 2022-01-25 Aaron J. Molstad , Adam J. Rothman

Ending the HIV/AIDS pandemic is among the Sustainable Development Goals for the next decade. In order to overcome the gap between the need for care and the available resources, better understanding of HIV epidemics is needed to guide policy…

Applications · Statistics 2020-09-03 Zhou Lan , Le Bao

We introduce a method called neighbor-based bootstrapping (NB2) that can be used to quantify the geospatial variation of a variable. We applied this method to an analysis of the incidence rates of disease from electronic medical record data…

Methodology · Statistics 2017-03-07 Maria T Patterson , Robert L Grossman

This paper studies a networked bivirus model, in which two competing viruses spread across a network of interconnected populations; each node represents a population with a large number of individuals. The viruses may spread through…

Dynamical Systems · Mathematics 2024-10-24 Mengbin Ye , Brian D. O. Anderson , Ji Liu

Human mobility is a key factor in spatial disease dynamics and related phenomena. In computational models host mobility is typically modelled by diffusion in space or on metapolulation networks. Alternatively, an effective force of…

Physics and Society · Physics 2012-03-07 Vitaly Belik , Theo Geisel , Dirk Brockmann

Since the last century, deterministic compartmental models have emerged as powerful tools to predict and control epidemic outbreaks, in many cases helping to mitigate their impacts. A key quantity for these models is the so-called Basic…

Populations and Evolution · Quantitative Biology 2022-11-03 Àlex Giménez-Romero , Rosa Flaquer-Galmés , Manuel A. Matias

We propose a working strategy to describe the eigenvalue statistics of random spin systems along the whole phase diagram with thermal to many-body localization (MBL) transition. Our strategy relies on two random matrix (RM) models with…

Disordered Systems and Neural Networks · Physics 2021-12-24 Wen-Jia Rao

The structure of heterogeneous networks and human mobility patterns profoundly influence the spreading of endemic diseases. In small-scale communities, individuals engage in social interactions within confined environments, such as homes…

Physics and Society · Physics 2025-05-20 Yusheng Li , Yichao Yao , Minyu Feng , Tina P. Benko , Matjaž Perc , Jernej Završnik

Transmission dynamics of infectious diseases are often studied using compartmental mathematical models, which are commonly represented as systems of autonomous ordinary differential equations. A key step in the analysis of such models is to…

Populations and Evolution · Quantitative Biology 2025-12-15 David J. D. Earn , C. Connell McCluskey

The paradigm for compartment models in epidemiology assumes exponentially distributed incubation and removal times, which is not realistic in actual populations. Commonly used variations with multiple exponentially distributed variables are…

Populations and Evolution · Quantitative Biology 2021-02-10 P. Hernández , C. Pena , A. Ramos , J. J. Gómez-Cadenas

One of the difficulties in monitoring an ongoing pandemic is deciding on the metric that best describes its status when multiple intercorrelated measurements are available. Having a single measure, such as the effective reproduction number…

Applications · Statistics 2022-04-20 Ben Swallow , Wen Xiang , Jasmina Panovska-Griffiths

Research in epidemiology often focusses on designing interventions that result in the number of infected individuals asymptotically approaching zero, without considering that this number may peak at high values during transients. Recent…

Optimization and Control · Mathematics 2020-03-24 Willem Esterhuizen , Tim Aschenbruck , Jean Lévine , Stefan Streif