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Molecule representation learning (MRL) methods aim to embed molecules into a real vector space. However, existing SMILES-based (Simplified Molecular-Input Line-Entry System) or GNN-based (Graph Neural Networks) MRL methods either take…

Machine Learning · Computer Science 2021-09-23 Hongwei Wang , Weijiang Li , Xiaomeng Jin , Kyunghyun Cho , Heng Ji , Jiawei Han , Martin D. Burke

In this paper, it is presented a methodology for implementing arbitrarily constructed time-homogenous Markov chains with biochemical systems. Not only discrete but also continuous-time Markov chains are allowed to be computed. By employing…

Molecular Networks · Quantitative Biology 2018-02-16 Chuan Zhang , Ziyuan Shen , Wei Wei , Jing Zhao , Zaichen Zhang , Xiaohu You

The restricted Boltzmann machine (RBM) has been successfully applied to solve the many-electron Schr$\ddot{\text{o}}$dinger equation. In this work we propose a single-layer fully connected neural network adapted from RBM and apply it to…

Quantum Physics · Physics 2023-01-11 Yangjun Wu , Xiansong Xu , Dario Poletti , Yi Fan , Chu Guo , Honghui Shang

Chinese Remainder Theorem (CRT) is a powerful approach to solve ambiguity resolution related problems such as undersampling frequency estimation and phase unwrapping which are widely applied in localization. Recently, the deterministic…

Information Theory · Computer Science 2018-07-03 Hanshen Xiao , Guoqiang Xiao

Random number generators (RNG) are an important resource in many areas: cryptography (both quantum and classical), probabilistic computation (Monte Carlo methods), numerical simulations, industrial testing and labeling, hazard games,…

Quantum Physics · Physics 2015-05-27 Mario Stipcevic

We introduce the R package clrng which leverages the gpuR package and is able to generate random numbers in parallel on a Graphics Processing Unit (GPU) with the clRNG (OpenCL) library. Parallel processing with GPU's can speed up…

Computation · Statistics 2024-04-16 Ruoyong Xu , Patrick Brown , Pierre L'Ecuyer

We present two quantitative behavioral equivalences over species of a chemical reaction network (CRN) with semantics based on ordinary differential equations. Forward CRN bisimulation identifies a partition where each equivalence class…

Logic in Computer Science · Computer Science 2015-07-16 Luca Cardelli , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

Exact inference in complex probabilistic models often incurs prohibitive computational costs. This challenge is particularly acute for autonomous agents in dynamic environments that require frequent, real-time belief updates. Existing…

Artificial Intelligence · Computer Science 2026-02-10 Simon Kohaut , Benedict Flade , Julian Eggert , Kristian Kersting , Devendra Singh Dhami

Robustness is an observable property for which a chemical reaction network (CRN) can maintain its functionalities despite the influence of different perturbations. In general, to verify whether a network is robust, it is necessary to…

Formal Languages and Automata Theory · Computer Science 2021-04-29 Lucia Nasti , Roberta Gori , Paolo Milazzo

Agent-based models (ABMs) are widely used to estimate causal treatment effects via paired counterfactual simulation. A standard variance reduction technique is common random numbers (CRNs), which couples replicates across intervention…

Methodology · Statistics 2026-03-13 Vince Buffalo , Carl A. B. Pearson , Daniel Klein

Organic synthesis stands as a cornerstone of the chemical industry. The development of robust machine learning models to support tasks associated with organic reactions is of significant interest. However, current methods rely on…

Machine Learning · Computer Science 2025-01-06 Kaipeng Zeng , Xianbin Liu , Yu Zhang , Xiaokang Yang , Yaohui Jin , Yanyan Xu

In order to fully exploit the potential of molecular communication (MC) for intra-body communication, practically implementable cellular receivers are an important long-term goal. A variety of receiver architectures based on chemical…

Emerging Technologies · Computer Science 2023-05-11 Bastian Heinlein , Lukas Brand , Malcolm Egan , Maximilian Schäfer , Robert Schober , Sebastian Lotter

Reaction virtual screening and discovery are fundamental challenges in chemistry and materials science, where traditional graph neural networks (GNNs) struggle to model multi-reactant interactions. In this work, we propose ChemHGNN, a…

Machine Learning · Computer Science 2025-06-16 Xiaobao Huang , Yihong Ma , Anjali Gurajapu , Jules Schleinitz , Zhichun Guo , Sarah E. Reisman , Nitesh V. Chawla

Recurrent neural networks (RNNs) are known to be universal approximators of dynamic systems under fairly mild and general assumptions. However, RNNs usually suffer from the issues of vanishing and exploding gradients in standard RNN…

Signal Processing · Electrical Eng. & Systems 2024-10-28 Shashank Jere , Lizhong Zheng , Karim Said , Lingjia Liu

A chemical reaction mechanism (CRM) is a sequence of molecular-level events involving bond-breaking/forming processes, generating transient intermediates along the reaction pathway as reactants transform into products. Understanding such…

Chemical Physics · Physics 2024-07-16 Ajnabiul Hoque , Manajit Das , Mayank Baranwal , Raghavan B. Sunoj

Deep learning has demonstrated success in many applications; however, their use in healthcare has been limited due to the lack of transparency into how they generate predictions. Algorithms such as Recurrent Neural Networks (RNNs) when…

Machine Learning · Computer Science 2021-01-14 Long V. Ho , Melissa D. Aczon , David Ledbetter , Randall Wetzel

Answering complex logical queries over large-scale knowledge graphs (KGs) represents an important artificial intelligence task, entailing a range of applications. Recently, knowledge representation learning (KRL) has emerged as the…

Cryptography and Security · Computer Science 2021-11-02 Zhaohan Xi , Ren Pang , Changjiang Li , Shouling Ji , Xiapu Luo , Xusheng Xiao , Ting Wang

Information processing relying on biochemical interactions in the cellular environment is essential for biological organisms. The implementation of molecular computational systems holds significant interest and potential in the fields of…

Dynamical Systems · Mathematics 2023-12-01 Yuzhen Fan , Xiaoyu Zhang , Chuanhou Gao , Denis Dochain

Liquid state nuclear magnetic resonance (NMR) techniques have produced some spectacular successes in the construction of small quantum computers, and NMR is currently by far the leading technology for quantum computation. There are,…

Quantum Physics · Physics 2015-06-26 J. A. Jones

Time series models with recurrent neural networks (RNNs) can have high accuracy but are unfortunately difficult to interpret as a result of feature-interactions, temporal-interactions, and non-linear transformations. Interpretability is…

Machine Learning · Computer Science 2021-09-17 Asif Rahman , Yale Chang , Jonathan Rubin