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Deep learning classifiers provide the most accurate means of automatically diagnosing diabetic retinopathy (DR) based on optical coherence tomography (OCT) and its angiography (OCTA). The power of these models is attributable in part to the…

Image and Video Processing · Electrical Eng. & Systems 2023-06-28 Pengxiao Zang , Tristan T. Hormel , Jie Wang , Yukun Guo , Steven T. Bailey , Christina J. Flaxel , David Huang , Thomas S. Hwang , Yali Jia

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to…

Medical Physics · Physics 2016-12-21 Yang Lou , Kun Wang , Alexander. A. Oraevsky , Mark. A. Anastasio

Optical coherence tomography angiography (OCTA) is a novel noninvasive imaging modality for visualization of retinal blood flow in the human retina. Using specific OCTA imaging biomarkers for the identification of pathologies, automated…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Anna Breger , Felix Goldbach , Bianca S. Gerendas , Ursula Schmidt-Erfurth , Martin Ehler

Recent studies suggest that early stages of diabetic retinopathy (DR) can be diagnosed by monitoring vascular changes in the deep vascular complex. In this work, we investigate a novel method for automated DR grading based on optical…

Image and Video Processing · Electrical Eng. & Systems 2022-12-22 Linus Kreitner , Ivan Ezhov , Daniel Rueckert , Johannes C. Paetzold , Martin J. Menten

Large language models (LLMs) often generate hallucinations -- unsupported content that undermines reliability. While most prior works frame hallucination detection as a binary task, many real-world applications require identifying…

The automatic detection of disease related entities in retinal imaging data is relevant for disease- and treatment monitoring. It enables the quantitative assessment of large amounts of data and the corresponding study of disease…

Precise, object-aware control over visual content is essential for advanced image editing and compositional generation. Yet, most existing approaches operate on entire images holistically, limiting the ability to isolate and manipulate…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Fangyi Chen , Yaojie Shen , Lu Xu , Ye Yuan , Shu Zhang , Yulei Niu , Longyin Wen

Objective: The advent of Electronic Medical Records (EMR) with large electronic imaging databases along with advances in deep neural networks with machine learning has provided a unique opportunity to achieve milestones in automated image…

Machine Learning · Statistics 2016-12-16 Cecilia S. Lee , Doug M. Baughman , Aaron Y. Lee

Optical Coherence Tomography (OCT) is an imaging modality that has been widely adopted for visualizing corneal, retinal and limbal tissue structure with micron resolution. It can be used to diagnose pathological conditions of the eye, and…

Image and Video Processing · Electrical Eng. & Systems 2019-05-08 Jiahong Ouyang , Tejas Sudharshan Mathai , Kira Lathrop , John Galeotti

Though deep learning has shown successful performance in classifying the label and severity stage of certain diseases, most of them give few explanations on how to make predictions. Inspired by Koch's Postulates, the foundation in…

Image and Video Processing · Electrical Eng. & Systems 2022-05-02 Yuhao Niu , Lin Gu , Yitian Zhao , Feng Lu

This paper presents dilated Residual Network (ResNet) models for disease classification from retinal fundus images. Dilated convolution filters are used to replace normal convolution filters in the higher layers of the ResNet model (dilated…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 P. N. Karthikayan , Yoga Sri Varshan , Hitesh Gupta Kattamuri , Umarani Jayaraman

In recent years, large language models (LLMs) have demonstrated remarkable potential across various medical applications. Building on this foundation, multimodal large language models (MLLMs) integrate LLMs with visual models to process…

Computation and Language · Computer Science 2025-03-11 Xiaoyi Liang , Mouxiao Bian , Moxin Chen , Lihao Liu , Junjun He , Jie Xu , Lin Li

Purpose: The purpose of this study was to develop and evaluate rule-based algorithms to enhance the extraction of text data, including retinal nerve fiber layer (RNFL) values and other ganglion cell count (GCC) data, from Zeiss Cirrus…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Iyad Majid , Youchen Victor Zhang , Robert Chang , Sophia Y. Wang

Optical coherence tomography (OCT) has become the most important imaging modality in ophthalmology. A substantial amount of research has recently been devoted to the development of machine learning (ML) models for the identification and…

In the real world, medical datasets often exhibit a long-tailed data distribution (i.e., a few classes occupy the majority of the data, while most classes have only a limited number of samples), which results in a challenging long-tailed…

Computer Vision and Pattern Recognition · Computer Science 2023-03-22 Lie Ju , Zhen Yu , Lin Wang , Xin Zhao , Xin Wang , Paul Bonnington , Zongyuan Ge

Medical imaging has revolutionized disease diagnosis, yet the potential is hampered by limited access to diverse and privacy-conscious datasets. Open-source medical datasets, while valuable, suffer from data quality and clinical information…

Image and Video Processing · Electrical Eng. & Systems 2023-12-13 Gauri Bhardwaj , Yuvaraj Govindarajulu , Sundaraparipurnan Narayanan , Pavan Kulkarni , Manojkumar Parmar

Objective: To develop an explainable multimodal large language model (MM-LLM) that (1) screens optic nerve head (ONH) OCT circle scans for quality and (2) generates structured clinical reports that include glaucoma diagnosis and sector-wise…

Optical tomographic cross-sectional images of biological samples were made possible by interferometric imaging techniques such as Optical Coherence Tomography (OCT). Owing to its unprecedented view of the sample, OCT has become a gold…

Medical Physics · Physics 2020-07-13 Pedro Mecê , Elena Gofas-Salas , Michel Paques , Kate Grieve , Serge Meimon

In this work, we propose an AI-based method that intends to improve the conventional retinal disease treatment procedure and help ophthalmologists increase diagnosis efficiency and accuracy. The proposed method is composed of a deep neural…

Computer Vision and Pattern Recognition · Computer Science 2020-11-03 Jia-Hong Huang , Chao-Han Huck Yang , Fangyu Liu , Meng Tian , Yi-Chieh Liu , Ting-Wei Wu , I-Hung Lin , Kang Wang , Hiromasa Morikawa , Hernghua Chang , Jesper Tegner , Marcel Worring

The caliber and configuration of retinal blood vessels serve as important biomarkers for various diseases and medical conditions. A thorough analysis of the retinal vasculature requires the segmentation of the blood vessels and their…

Image and Video Processing · Electrical Eng. & Systems 2025-03-13 José Morano , Guilherme Aresta , Hrvoje Bogunović
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