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This article critically examines the methodologies applied in ancient DNA (aDNA) research, particularly those developed by Dr. P\"a\"abo's team, which have significantly influenced the field. The focus is on the challenges of distinguishing…

We consider the problem of extracting curve skeletons of three-dimensional, elongated objects given a noisy surface, which has applications in agricultural contexts such as extracting the branching structure of plants. We describe an…

Computer Vision and Pattern Recognition · Computer Science 2018-03-20 Amy Tabb , Henry Medeiros

Since the release of human genome sequences, one of the most important research issues is about indexing the genome sequences, and the suffix tree is most widely adopted for that purpose. The traditional suffix tree construction algorithms…

Databases · Computer Science 2015-05-20 Woong-Kee Loh , Yang-Sae Moon , Wookey Lee

A number of bioinformatic or biostatistical methods are available for analyzing DNA copy number profiles measured from microarray or sequencing technologies. In the absence of rich enough gold standard data sets, the performance of these…

Quantitative Methods · Quantitative Biology 2015-11-06 Morgane Pierre-Jean , Guillem Rigaill , Pierre Neuvial

Detecting object skeletons in natural images presents challenging, due to varied object scales, the complexity of backgrounds and various noises. The skeleton is a highly compressing shape representation, which can bring some essential…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Xiuxiu Bai , Lele Ye , Zhe Liu

With the prevalence of accessible depth sensors, dynamic human body skeletons have attracted much attention as a robust modality for action recognition. Previous methods model skeletons based on RNN or CNN, which has limited expressive…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Xiang Gao , Wei Hu , Jiaxiang Tang , Jiaying Liu , Zongming Guo

Computational methods for discovering patterns of local correlations in sequences are important in computational biology. Here we show how to determine the optimal partitioning of aligned sequences into non-overlapping segments such that…

Computational Engineering, Finance, and Science · Computer Science 2012-06-26 Joseph Bockhorst , Nebojsa Jojic

In this paper, we present a deep learning-based image processing technique for extraction of bone structures in chest radiographs using a U-Net FCNN. The U-Net was trained to accomplish the task in a fully supervised setting. To create the…

Computer Vision and Pattern Recognition · Computer Science 2020-03-25 Ophir Gozes , Hayit Greenspan

Objectives: The vast and complex nature of human genomic sequencing data presents challenges for effective analysis. This review aims to investigate the application of Natural Language Processing (NLP) techniques, particularly Large…

Genomics · Quantitative Biology 2025-02-28 Shuyan Cheng , Yishu Wei , Yiliang Zhou , Zihan Xu , Drew N Wright , Jinze Liu , Yifan Peng

To test the effectiveness of process discovery algorithms, a Process Discovery Contest (PDC) has been set up. This PDC uses a classification approach to measure this effectiveness: The better the discovered model can classify whether or not…

Artificial Intelligence · Computer Science 2018-06-22 H. M. W. Verbeek , R. Medeiros de Carvalho

Since the arrival of next-generation sequencing technologies the amount of genetic sequencing data has increased dramatically. This has has fueled an increase in human genetics research. At the same time, with the recent advent of…

Genomics · Quantitative Biology 2016-07-04 Kristiina Ausmees , Pushpam Aji John

Dual-energy computed tomography (DECT) has been widely used to obtain quantitative elemental composition of imaged subjects for personalized and precise medical diagnosis. Compared with existing high-end DECT leveraging advanced X-ray…

Medical Physics · Physics 2024-08-13 Qiaoxin Li , Dong Liang , Yinsheng Li

Motivated by the current COVID-19 health-crisis, we examine the task of baseline subtraction for quantitative polymerase chain-reaction (qPCR) measurements. In particular, we present an algorithm that leverages information obtained from…

Quantitative Methods · Quantitative Biology 2020-04-14 Paul N. Patrone , Anthony J. Kearsley , Erica L. Romsos , Peter M. Vallone

The goal of the trace reconstruction problem is to recover a string $x\in\{0,1\}^n$ given many independent {\em traces} of $x$, where a trace is a subsequence obtained from deleting bits of $x$ independently with some given probability…

Information Theory · Computer Science 2024-01-30 Kuan Cheng , Elena Grigorescu , Xin Li , Madhu Sudan , Minshen Zhu

Traditionally, we usually utilize the method of shotgun to cut a DNA sequence into pieces and we have to reconstruct the original DNA sequence from the pieces, those are widely used method for DNA assembly. Emerging DNA sequence…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-04-15 Yukun Zhong , ZhiWei He , XianHong Wang , XiongBin Cao

A significant portion of the data available today is found within tables. Therefore, it is necessary to use automated table extraction to obtain thorough results when data-mining. Today's popular state-of-the-art methods for table…

Information Retrieval · Computer Science 2021-04-26 Zach Colter , Morteza Fayazi , Zineb Benameur-El , Serafina Kamp , Shuyan Yu , Ronald Dreslinski

The classification of DNA sequences is a key research area in bioinformatics as it enables researchers to conduct genomic analysis and detect possible diseases. In this paper, three state-of-the-art algorithms, namely Convolutional Neural…

Other Quantitative Biology · Quantitative Biology 2020-11-03 Xiangxie Zhang , Ben Beinke , Berlian Al Kindhi , Marco Wiering

Technical signs of progress during the last decades has led to a situation in which the accumulation of genome sequence data is increasingly fast and cheap. The huge amount of molecular data available nowadays can help addressing new and…

Genomics · Quantitative Biology 2017-05-02 Christophe Guyeux , Bashar Al-Nuaimi , Bassam AlKindy , Jean-François Couchot , Michel Salomon

DNA is now routinely used in criminal investigations and court cases, although DNA samples taken at crime scenes are of varying quality and therefore present challenging problems for their interpretation. We present a statistical model for…

Methodology · Statistics 2013-12-11 R. G. Cowell , T. Graversen , S. Lauritzen , J. Mortera

Deep learning techniques are being used in skeleton based action recognition tasks and outstanding performance has been reported. Compared with RNN based methods which tend to overemphasize temporal information, CNN-based approaches can…

Computer Vision and Pattern Recognition · Computer Science 2017-05-03 Zewei Ding , Pichao Wang , Philip O. Ogunbona , Wanqing Li
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