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Motivated by data analysis and machine learning applications, we consider the popular high-dimensional Euclidean $k$-median and $k$-means problems. We propose a new primal-dual algorithm, inspired by the classic algorithm of Jain and…
In the era of foundation models and Large Language Models (LLMs), Euclidean space is the de facto geometric setting of our machine learning architectures. However, recent literature has demonstrated that this choice comes with fundamental…
Almost all statistical and machine learning methods in analyzing brain networks rely on distances and loss functions, which are mostly Euclidean or matrix norms. The Euclidean or matrix distances may fail to capture underlying subtle…
Graph-based methods provide a powerful tool set for many non-parametric frameworks in Machine Learning. In general, the memory and computational complexity of these methods is quadratic in the number of examples in the data which makes them…
Continual learning aims to efficiently learn from a non-stationary stream of data while avoiding forgetting the knowledge of old data. In many practical applications, data complies with non-Euclidean geometry. As such, the commonly used…
Euclidean embeddings of data are fundamentally limited in their ability to capture latent semantic structures, which need not conform to Euclidean spatial assumptions. Here we consider an alternative, which embeds data as discrete…
Depth measures have gained popularity in the statistical literature for defining level sets in complex data structures like multivariate data, functional data, and graphs. Despite their versatility, integrating depth measures into…
Geometric deep learning can find representations that are optimal for a given task and therefore improve the performance over pre-defined representations. While current work has mainly focused on point representations, meshes also contain…
Statistical analysis and inferences on spike trains are one of the central topics in neural coding. It is of great interest to understand the underlying distribution and geometric structure of given spike train data. However, a fundamental…
The Euclidean Median (EM) of a set of points $\Omega$ in an Euclidean space is the point x minimizing the (weighted) sum of the Euclidean distances of x to the points in $\Omega$. While there exits no closed-form expression for the EM, it…
This paper explores methods for estimating or approximating the total variation distance and the chi-squared divergence of probability measures within topological sample spaces, using independent and identically distributed samples. Our…
In this article, we analyze the morphometry of hippocampus in subjects with very mild dementia of Alzheimer's type (DAT) and nondemented controls and how it changes over a two-year period. Morphometric differences with respect to a template…
A new multivariate concept of quantile, based on a directional version of Koenker and Bassett's traditional regression quantiles, is introduced for multivariate location and multiple-output regression problems. In their empirical version,…
Alzheimer's disease (AD) exhibits substantial clinical and biological heterogeneity, complicating efforts in treatment and intervention development. While new computational methods offer insights into AD progression, the reproducibility of…
Finding meaningful distances between high-dimensional data samples is an important scientific task. To this end, we propose a new tree-Wasserstein distance (TWD) for high-dimensional data with two key aspects. First, our TWD is specifically…
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression…
K-Means clustering algorithm is one of the most commonly used clustering algorithms because of its simplicity and efficiency. K-Means clustering algorithm based on Euclidean distance only pays attention to the linear distance between…
Deep Neural Networks (DNNs) have an enormous potential to learn from complex biomedical data. In particular, DNNs have been used to seamlessly fuse heterogeneous information from neuroanatomy, genetics, biomarkers, and neuropsychological…
Unsupervised deep metric learning (UDML) focuses on learning a semantic representation space using only unlabeled data. This challenging problem requires accurately estimating the similarity between data points, which is used to supervise a…
We consider the problem of estimating the locations of a set of points in a k-dimensional euclidean space given a subset of the pairwise distance measurements between the points. We focus on the case when some fraction of these measurements…