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This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

Information Theory · Computer Science 2023-04-21 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

This paper studies reconstruction of strings based upon their substrings spectrum. Under this paradigm, it is assumed that all substrings of some fixed length are received and the goal is to reconstruct the string. While many existing works…

Information Theory · Computer Science 2021-06-02 Sagi Marcovich , Eitan Yaakobi

This paper studies the problem of encoding messages into sequences which can be uniquely recovered from some noisy observations about their substrings. The observed reads comprise consecutive substrings with some given minimum overlap. This…

Information Theory · Computer Science 2023-12-11 Hengjia Wei , Moshe Schwartz , Gennian Ge

The problem of reconstructing strings from their substring spectra has a long history and in its most simple incarnation asks for determining under which conditions the spectrum uniquely determines the string. We study the problem of coded…

Information Theory · Computer Science 2019-04-24 Ryan Gabrys , Olgica Milenkovic

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

Information Theory · Computer Science 2022-05-10 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

Motivated by mass-spectrometry protein sequencing, we consider a simply-stated problem of reconstructing a string from the multiset of its substring compositions. We show that all strings of length 7, one less than a prime, or one less than…

Discrete Mathematics · Computer Science 2014-03-12 Jayadev Acharya , Hirakendu Das , Olgica Milenkovic , Alon Orlitsky , Shengjun Pan

The problem of reconstructing strings from substring information has found many applications due to its importance in genomic data sequencing and DNA- and polymer-based data storage. One practically important and challenging paradigm…

Information Theory · Computer Science 2021-10-07 Ryan Gabrys , Srilakshmi Pattabiraman , Olgica Milenkovic

Motivated by applications in polymer-based data storage, we study the problem of reconstructing a string from part of its composition multiset. We give a full description of the structure of the strings that cannot be uniquely reconstructed…

Information Theory · Computer Science 2022-10-18 Zuo Ye , Ohad Elishco

The problem of string reconstruction from substring information has found many applications due to its relevance in DNA- and polymer-based data storage. One practically important and challenging paradigm requires reconstructing mixtures of…

Information Theory · Computer Science 2020-10-22 Ryan Gabrys , Srilakshmi Pattabiraman , Olgica Milenkovic

In the trace reconstruction problem, one seeks to reconstruct a binary string $s$ from a collection of traces, each of which is obtained by passing $s$ through a deletion channel. It is known that $\exp(\tilde O(n^{1/5}))$ traces suffice to…

Information Theory · Computer Science 2022-10-21 Kayvon Mazooji , Ilan Shomorony

We consider the problem of binary string reconstruction from the multiset of its substring compositions, i.e., referred to as the substring composition multiset, first introduced and studied by Acharya et al. We introduce a new algorithm…

Information Theory · Computer Science 2023-06-05 Utkarsh Gupta , Hessam Mahdavifar

The problem called "String reconstruction from substrings" is a mathematical model of sequencing by hybridization that plays an important role in DNA sequencing. In this problem, we are given a blackbox oracle holding an unknown string…

Data Structures and Algorithms · Computer Science 2018-08-03 Kazuo Iwama , Junichi Teruyama , Shuntaro Tsuyama

The problem of reconstructing a sequence from the set of its length-$k$ substrings has received considerable attention due to its various applications in genomics. We study an uncoded version of this problem where multiple random sources…

Information Theory · Computer Science 2023-05-11 Kel Levick , Ilan Shomorony

This paper investigates the number of quantum queries made to solve the problem of reconstructing an unknown string from its substrings in a certain query model. More concretely, the goal of the problem is to identify an unknown string $S$…

We consider the problem of coding for the substring channel, in which information strings are observed only through their (multisets of) substrings. Due to existing DNA sequencing techniques and applications in DNA-based storage systems,…

Information Theory · Computer Science 2024-03-27 Yonatan Yehezkeally , Nikita Polyanskii

In the trace reconstruction problem our goal is to learn an unknown string $x\in \{0,1\}^n$ given independent traces of $x$. A trace is obtained by independently deleting each bit of $x$ with some probability $\delta$ and concatenating the…

Data Structures and Algorithms · Computer Science 2024-12-02 Anders Aamand , Allen Liu , Shyam Narayanan

Consider two or more strings $\mathbf{x}^1,\mathbf{x}^2,\ldots,$ that are concatenated to form $\mathbf{x}=\langle \mathbf{x}^1,\mathbf{x}^2,\ldots \rangle$. Suppose that up to $\delta$ deletions occur in each of the concatenated strings.…

Information Theory · Computer Science 2023-04-20 Serge Kas Hanna

Motivated by polymer-based data-storage platforms that use chains of binary synthetic polymers as the recording media and read the content via tandem mass spectrometers, we propose a new family of codes that allows for unique string…

Information Theory · Computer Science 2019-04-22 Srilakshmi Pattabiraman , Ryan Gabrys , Olgica Milenkovic

In the usual trace reconstruction problem, the goal is to exactly reconstruct an unknown string of length $n$ after it passes through a deletion channel many times independently, producing a set of traces (i.e., random subsequences of the…

Data Structures and Algorithms · Computer Science 2020-12-17 Sami Davies , Miklos Z. Racz , Cyrus Rashtchian , Benjamin G. Schiffer

DNA has immense potential as an emerging data storage medium. The principle of DNA storage is the conversion and flow of digital information between binary code stream, quaternary base, and actual DNA fragments. This process will inevitably…

Information Retrieval · Computer Science 2022-10-21 Yun Qin , Fei Zhu , Bo Xi
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