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This study integrates PET metabolic information with CT anatomical structures to establish a 3D multimodal segmentation dataset for lymphoma based on whole-body FDG PET/CT examinations, which bridges the gap of the lack of standardised…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Jiajun Ding , Beiyao Zhu , Xiaosheng Liu , Lishen Zhang , Zhao Liu

In the field of computational pathology, deep learning algorithms have made significant progress in tasks such as nuclei segmentation and classification. However, the potential of these advanced methods is limited by the lack of available…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Hyun-Jic Oh , Won-Ki Jeong

Segmentation is essential for medical image analysis tasks such as intervention planning, therapy guidance, diagnosis, treatment decisions. Deep learning is becoming increasingly prominent for segmentation, where the lack of annotations,…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Firat Ozdemir , Zixuan Peng , Christine Tanner , Philipp Fuernstahl , Orcun Goksel

Colorectal diseases, including inflammatory conditions and neoplasms, require quick, accurate care to be effectively treated. Traditional diagnostic pipelines require extensive preparation and rely on separate, individual evaluations on…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Krithik Ramesh , Ritvik Koneru

From the simple measurement of tissue attributes in pathology workflow to designing an explainable diagnostic/prognostic AI tool, access to accurate semantic segmentation of tissue regions in histology images is a prerequisite. However,…

Image and Video Processing · Electrical Eng. & Systems 2021-08-31 Mostafa Jahanifar , Neda Zamani Tajeddin , Navid Alemi Koohbanani , Nasir Rajpoot

Due to morphological similarities, the differentiation of histologic sections of cutaneous tumors into individual subtypes can be challenging. Recently, deep learning-based approaches have proven their potential for supporting pathologists…

This work addresses how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. We use images with annotated tumor regions to identify a set of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Mohammad Iqbal Nouyed , Mary-Anne Hartley , Gianfranco Doretto , Donald A. Adjeroh

Due to the wide existence and large morphological variances of nuclei, accurate nuclei instance segmentation is still one of the most challenging tasks in computational pathology. The annotating of nuclei instances, requiring experienced…

Computer Vision and Pattern Recognition · Computer Science 2020-07-23 Xinpeng Xie , Jiawei Chen , Yuexiang Li , Linlin Shen , Kai Ma , Yefeng Zheng

The quantification of biomarkers on immunohistochemistry breast cancer images is essential for defining appropriate therapy for breast cancer patients, as well as for extracting relevant information on disease prognosis. This is an arduous…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Blanca Maria Priego-Torresa , Barbara Lobato-Delgado , Lidia Atienza-Cuevas , Daniel Sanchez-Morillo

Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected…

Image and Video Processing · Electrical Eng. & Systems 2023-02-10 John-Melle Bokhorst , Iris D. Nagtegaal , Filippo Fraggetta , Simona Vatrano , Wilma Mesker , Michael Vieth , Jeroen van der Laak , Francesco Ciompi

Liver cancer has a high incidence rate, but primary healthcare settings often lack experienced doctors. Advances in large models and AI technologies offer potential assistance. This work aims to address limitations in liver cancer diagnosis…

Medical Physics · Physics 2024-06-27 Xuzhou Wu , Guangxin Li , Xing Wang , Zeyu Xu , Yingni Wang , Jianming Xian , Xueyu Wang , Gong Li , Kehong Yuan

The distribution and appearance of nuclei are essential markers for the diagnosis and study of cancer. Despite the importance of nuclear morphology, there is a lack of large scale, accurate, publicly accessible nucleus segmentation data. To…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Le Hou , Rajarsi Gupta , John S. Van Arnam , Yuwei Zhang , Kaustubh Sivalenka , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

Accurate segmentation of tissue in histopathological images can be very beneficial for defining regions of interest (ROI) for streamline of diagnostic and prognostic tasks. Still, adapting to different domains is essential for…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Saul Fuster , Farbod Khoraminia , Trygve Eftestøl , Tahlita C. M. Zuiverloon , Kjersti Engan

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

Nuclear segmentation in histology images is a challenging task due to significant variations in the shape and appearance of nuclei. One of the main hurdles in nuclear instance segmentation is overlapping nuclei where a smart algorithm is…

Image and Video Processing · Electrical Eng. & Systems 2019-08-28 Navid Alemi Koohbanani , Mostafa Jahanifar , Ali Gooya , Nasir Rajpoot

Deep-learning-based pipelines have shown the potential to revolutionalize microscopy image diagnostics by providing visual augmentations to a trained pathology expert. However, to match human performance, the methods rely on the…

Nuclei segmentation is a fundamental task in histopathology image analysis. Typically, such segmentation tasks require significant effort to manually generate accurate pixel-wise annotations for fully supervised training. To alleviate such…

Computer Vision and Pattern Recognition · Computer Science 2020-07-13 Hui Qu , Pengxiang Wu , Qiaoying Huang , Jingru Yi , Zhennan Yan , Kang Li , Gregory M. Riedlinger , Subhajyoti De , Shaoting Zhang , Dimitris N. Metaxas

Accurate cell segmentation in pathology images typically requires dense pixel-wise annotations, which are costly and time-consuming to obtain. This challenge is especially important for emerging biological imaging modalities and multiplexed…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Gunjan Shrivastava , Saad Nadeem

Two of the most common tasks in medical imaging are classification and segmentation. Either task requires labeled data annotated by experts, which is scarce and expensive to collect. Annotating data for segmentation is generally considered…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Ozan Ciga , Anne L. Martel

Tissue phenotyping is a fundamental computational pathology (CPath) task in learning objective characterizations of histopathologic biomarkers in anatomic pathology. However, whole-slide imaging (WSI) poses a complex computer vision problem…