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Accurate and fast histological staining is crucial in histopathology, impacting diagnostic precision and reliability. Traditional staining methods are time-consuming and subjective, causing delays in diagnosis. Digital pathology plays a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-06 Marian Boktor , James E. D. Tweel , Benjamin R. Ecclestone , Jennifer Ai Ye , Paul Fieguth , Parsin Haji Reza

Skin cancer is the most common cancer in the existing world constituting one-third of the cancer cases. Benign skin cancers are not fatal, can be cured with proper medication. But it is not the same as the malignant skin cancers. In the…

Image and Video Processing · Electrical Eng. & Systems 2022-12-21 Dusa Sai Charan , Hemanth Nadipineni , Subin Sahayam , Umarani Jayaraman

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Quantitative Methods · Quantitative Biology 2025-07-10 Changchun Yang , Haoyang Li , Yushuai Wu , Yilan Zhang , Yifeng Jiao , Yu Zhang , Rihan Huang , Yuan Cheng , Yuan Qi , Xin Guo , Xin Gao

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

Tissues and Organs · Quantitative Biology 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

Early diagnosis of melanoma, which can save thousands of lives, relies heavily on the analysis of dermoscopic images. One crucial diagnostic criterion is the identification of unusual pigment network (PN). However, distinguishing between…

Image and Video Processing · Electrical Eng. & Systems 2026-01-21 M. A. Rasel , Sameem Abdul Kareem , Unaizah Obaidellah

Convolutional Neural Networks have demonstrated dermatologist-level performance in the classification of melanoma from skin lesion images, but prediction irregularities due to biases seen within the training data are an issue that should be…

Computer Vision and Pattern Recognition · Computer Science 2023-04-28 Peter J. Bevan , Amir Atapour-Abarghouei

Skin cancer detection is challenging since different types of skin lesions share high similarities. This paper proposes a computer-based deep learning approach that will accurately identify different kinds of skin lesions. Deep learning…

Computer Vision and Pattern Recognition · Computer Science 2023-03-15 Mst Shapna Akter , Hossain Shahriar , Sweta Sneha , Alfredo Cuzzocrea

Machine-learning models applied to skin images often have degraded performance when the skin colour captured in images (SCCI) differs between training and deployment. These discrepancies arise from a combination of entangled environmental…

Image and Video Processing · Electrical Eng. & Systems 2026-02-27 Wenbo Yang , Eman Rezk , Walaa M. Moursi , Zhou Wang

We propose a novel approach for visual representation learning called Signature-Graph Neural Networks (SGN). SGN learns latent global structures that augment the feature representation of Convolutional Neural Networks (CNN). SGN constructs…

Computer Vision and Pattern Recognition · Computer Science 2021-10-25 Ali Hamdi , Flora Salim , Du Yong Kim , Xiaojun Chang

Seed phenotyping is the idea of analyzing the morphometric characteristics of a seed to predict the behavior of the seed in terms of development, tolerance and yield in various environmental conditions. The focus of the work is the…

Computer Vision and Pattern Recognition · Computer Science 2020-12-25 Venkat Margapuri , Mitchell Neilsen

Skin lesion segmentation is one of the crucial steps for an efficient non-invasive computer-aided early diagnosis of melanoma. This paper investigates how color information, besides saliency, can be used to determine the pigmented lesion…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Giuliana Ramella

Self-Supervised Learning (SSL) has been shown to learn useful and information-preserving representations. Neural Networks (NNs) are widely applied, yet their weight space is still not fully understood. Therefore, we propose to use SSL to…

Machine Learning · Computer Science 2022-12-15 Konstantin Schürholt , Dimche Kostadinov , Damian Borth

In this paper, we proposed using a hybrid method that utilises deep convolutional and recurrent neural networks for accurate delineation of skin lesion of images supplied with ISBI 2017 lesion segmentation challenge. The proposed method was…

Computer Vision and Pattern Recognition · Computer Science 2017-03-02 M. Attia , M. Hossny , S. Nahavandi , A. Yazdabadi

Deploying generative machine learning techniques to generate novel chemical structures based on molecular fingerprint representation has been well established in molecular design. Typically, sequential learning (SL) schemes such as hidden…

Biomolecules · Quantitative Biology 2022-04-07 Mohammad Sajjad Ghaemi , Karl Grantham , Isaac Tamblyn , Yifeng Li , Hsu Kiang Ooi

The advancement of Spatial Transcriptomics (ST) has facilitated the spatially-aware profiling of gene expressions based on histopathology images. Although ST data offers valuable insights into the micro-environment of tumors, its…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Hongyi Wang , Xiuju Du , Jing Liu , Shuyi Ouyang , Yen-Wei Chen , Lanfen Lin

Spatially resolved transcriptomics (ST) measures gene expression along with the spatial coordinates of the measurements. The analysis of ST data involves significant computation complexity. In this work, we propose gene expression…

Genomics · Quantitative Biology 2022-05-24 Zhuoyan Xu , Kris Sankaran

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung

In this paper we present a methodology that uses convolutional neural networks (CNNs) for segmentation by iteratively growing predicted mask regions in each coordinate direction. The CNN is used to predict class probability scores in a…

Image and Video Processing · Electrical Eng. & Systems 2020-09-25 John Lagergren , Erica Rutter , Kevin Flores

Spatial transcriptomics (ST) technologies can be used to align transcriptomes with histopathological morphology, presenting exciting new opportunities for biomolecular discovery. Using ST data, we construct a novel framework, GeneFlow, to…

Quantitative Methods · Quantitative Biology 2025-11-04 Mengbo Wang , Shourya Verma , Aditya Malusare , Luopin Wang , Yiyang Lu , Vaneet Aggarwal , Mario Sola , Ananth Grama , Nadia Atallah Lanman

Neuro-encoded expression programming(NEEP) that aims to offer a novel continuous representation of combinatorial encoding for genetic programming methods is proposed in this paper. Genetic programming with linear representation uses…

Neural and Evolutionary Computing · Computer Science 2021-04-12 Aftab Anjum , Fengyang Sun , Lin Wang , Jeff Orchard
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