Related papers: Error Catastrophe Can Be Avoided by Proofreading I…
Pre-trained large text-to-image (T2I) models with an appropriate text prompt has attracted growing interests in customized images generation field. However, catastrophic forgetting issue make it hard to continually synthesize new…
Many biological processes discriminate between correct and incorrect substrates through the kinetic proofreading mechanism which enables lower error at the cost of higher energy dissipation. Elucidating physicochemical constraints for…
Biopolymer length regulation is a complex process that involves a large number of subprocesses acting simultaneously across multiple spatial and temporal scales. An illustrative example important for genomic stability is the length…
The emergence of longer information-carrying and functional nucleotide polymers from random short strands was a major stepping stone at the dawn of life. But the formation of those polymers under temperature oscillation required some form…
Justifying the correct implementation of the non-functional requirements (e.g., safety, security) of mission-critical systems is crucial to prevent system failure. The later could have severe consequences such as the death of people and…
For a simple model of mutually interacting qubits it is shown how the errors induced by mutual interactions can be eliminated using concatenated coding. The model is solved exactly for arbitrary interaction strength, for two well-known…
The widespread use of generative models has created a feedback loop, in which each generation of models is trained on data partially produced by its predecessors. This process has raised concerns about model collapse: A critical degradation…
Hypercycles are information integration systems which are thought to overcome the information crisis of prebiotic evolution by ensuring the coexistence of several short templates. For imperfect template replication, we derive a simple…
We axiomatize the molecular-biology reasoning style, show compliance of the standard reference: Ptashne, A Genetic Switch, and present proof-theory-induced technologies to help infer phenotypes and to predict life cycles from genotypes. The…
Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in…
Polymerization is a fundamental chemical process enabling large-scale production of material components across modern industries. By transforming a monomer mixture into a cross-linked polymer network, polymerization induces changes in…
Motivated by mutation processes occurring in in-vivo DNA-storage applications, a channel that mutates stored strings by duplicating substrings as well as substituting symbols is studied. Two models of such a channel are considered: one in…
Software synthesis - the process of generating complete, general-purpose programs from specifications - has become a hot research topic in the past few years. For decades the problem was thought to be insurmountable: the search space of…
Societal accumulation of knowledge is a complex process. The correctness of new units of knowledge depends not only on the correctness of new reasoning, but also on the correctness of old units that the new one builds on. The errors in such…
We report molecular dynamics simulations of a system of repulsive, polymer-tethered colloidal particles. We use an explicit polymer model to explore how the length and the behavior of the polymer (ideal or self-avoiding) affect the ability…
Vitrimer is an emerging class of sustainable polymers with self-healing capabilities enabled by dynamic covalent adaptive networks. However, their limited molecular diversity constrains their property space and potential applications.…
Progressive damage, which eventually leads to failure, is ubiquitous in biological and synthetic polymers. The simplest case to consider is that of elastomeric materials, which can undergo large reversible deformations with negligible rate…
Polymers are candidate materials for a wide range of sustainability applications such as carbon capture and energy storage. However, computational polymer discovery lacks automated analysis of reaction pathways and stability assessment…
The early and robust detection of anomalies occurring in discrete manufacturing processes allows operators to prevent harm, e.g. defects in production machinery or products. While current approaches for data-driven anomaly detection provide…
Enzyme is the major workhorse to carry out the diverse cellular functions. It catalyzes the biological reactions with a high specificity, with its topology playing a crucial role. For ecologically safe production of numerous bioproducts…