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Tumor segmentation in whole-slide images of histology slides is an important step towards computer-assisted diagnosis. In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles…

Computer Vision and Pattern Recognition · Computer Science 2018-05-11 Talha Qaiser , Yee-Wah Tsang , Daiki Taniyama , Naoya Sakamoto , Kazuaki Nakane , David Epstein , Nasir Rajpoot

Accurate patient diagnoses based on human tissue biopsies are hindered by current clinical practice, where pathologists assess only a limited number of thin 2D tissue slices sectioned from 3D volumetric tissue. Recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Gan Gao , Andrew H. Song , Fiona Wang , David Brenes , Rui Wang , Sarah S. L. Chow , Kevin W. Bishop , Lawrence D. True , Faisal Mahmood , Jonathan T. C. Liu

Automatic outlining of different tissue types in digitized histological specimen provides a basis for follow-up analyses and can potentially guide subsequent medical decisions. The immense size of whole-slide-images (WSI), however, poses a…

Automatic detection of abnormal cervical cells from Thinprep Cytologic Test (TCT) images is a critical component in the development of intelligent computer-aided diagnostic systems. However, existing algorithms typically fail to effectively…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Jincheng Li , Danyang Dong , Menglin Zheng , Jingbo Zhang , Yueqin Hang , Lichi Zhang , Lili Zhao

Accurate recurrence risk stratification is crucial for optimizing treatment plans for breast cancer patients. Current prognostic tools like Oncotype DX (ODX) offer valuable genomic insights for HR+/HER2- patients but are limited by cost and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-25 Ziyu Su , Yongxin Guo , Robert Wesolowski , Gary Tozbikian , Nathaniel S. O'Connell , M. Khalid Khan Niazi , Metin N. Gurcan

Lung cancer is a very deadly disease worldwide, and its early diagnosis is crucial for increasing patient survival rates. Computed tomography (CT) scans are widely used for lung cancer diagnosis as they can give detailed lung structures.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Md Rashidul Islam , Bakary Gibba , Altagi Abdallah Bakheit Abdelgadir

Non-invasive radiological-based lesion characterization and identification, e.g., to differentiate cancer subtypes, has long been a major aim to enhance oncological diagnosis and treatment procedures. Here we study a specific population of…

Computer Vision and Pattern Recognition · Computer Science 2020-09-01 Yuankai Huo , Jinzheng Cai , Chi-Tung Cheng , Ashwin Raju , Ke Yan , Bennett A. Landman , Jing Xiao , Le Lu , Chien-Hung Liao , Adam P. Harrison

An automatic segmentation algorithm for delineation of the gross tumour volume and pathologic lymph nodes of head and neck cancers in PET/CT images is described. The proposed algorithm is based on a convolutional neural network using the…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Yngve Mardal Moe , Aurora Rosvoll Groendahl , Martine Mulstad , Oliver Tomic , Ulf Indahl , Einar Dale , Eirik Malinen , Cecilia Marie Futsaether

Minimally invasive image-guided surgery heavily relies on vision. Deep learning models for surgical video analysis could therefore support visual tasks such as assessing the critical view of safety (CVS) in laparoscopic cholecystectomy…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Pietro Mascagni , Deepak Alapatt , Alain Garcia , Nariaki Okamoto , Armine Vardazaryan , Guido Costamagna , Bernard Dallemagne , Nicolas Padoy

Automated breast cancer detection via computer vision techniques is challenging due to the complex nature of breast tissue, the subtle appearance of cancerous lesions, and variations in breast density. Mainstream techniques primarily focus…

Quantitative Methods · Quantitative Biology 2025-12-11 Noor Ul Huda Shah , Tanveer Hussain , Amr Ahmed , Yonghuai Liu , Usman Ali , Ardhendu Behera

In nuclear imaging, limited resolution causes partial volume effects (PVEs) that affect image sharpness and quantitative accuracy. Partial volume correction (PVC) methods incorporating high-resolution anatomical information from CT or MRI…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 Huidong Xie , Zhao Liu , Luyao Shi , Kathleen Greco , Xiongchao Chen , Bo Zhou , Attila Feher , John C. Stendahl , Nabil Boutagy , Tassos C. Kyriakides , Ge Wang , Albert J. Sinusas , Chi Liu

We propose a novel pathology-sensitive deep learning model (PS-DeVCEM) for frame-level anomaly detection and multi-label classification of different colon diseases in video capsule endoscopy (VCE) data. Our proposed model is capable of…

Computer Vision and Pattern Recognition · Computer Science 2020-11-30 A. Mohammed , I. Farup , M. Pedersen , S. Yildirim , Ø Hovde

Purpose: In some proton therapy facilities, patient alignment relies on two 2D orthogonal kV images, taken at fixed, oblique angles, as no 3D on-the-bed imaging is available. The visibility of the tumor in kV images is limited since the…

Computer Vision and Pattern Recognition · Computer Science 2023-10-19 Yuzhen Ding , Hongying Feng , Yunze Yang , Jason Holmes , Zhengliang Liu , David Liu , William W. Wong , Nathan Y. Yu , Terence T. Sio , Steven E. Schild , Baoxin Li , Wei Liu

In this study, with the goal of reducing the early detection miss rate of colorectal cancer (CRC) polyps, we propose utilizing a novel hyper-sensitive vision-based tactile sensor called HySenSe and a complementary and novel machine learning…

Machine Learning · Computer Science 2022-11-15 Nethra Venkatayogi , Qin Hu , Ozdemir Can Kara , Tarunraj G. Mohanraj , S. Farokh Atashzar , Farshid Alambeigi

Microscopic examination of tissues or histopathology is one of the diagnostic procedures for detecting colorectal cancer. The pathologist involved in such an examination usually identifies tissue type based on texture analysis, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Srinath Jayachandran , Ashlin Ghosh

Prostate cancer (PCa) was the most frequently diagnosed cancer among American men in 2023. The histological grading of biopsies is essential for diagnosis, and various deep learning-based solutions have been developed to assist with this…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Ekaterina Redekop , Mara Pleasure , Zichen Wang , Anthony Sisk , Yang Zong , Kimberly Flores , William Speier , Corey W. Arnold

In recent years, histopathology images have been increasingly used as a diagnostic tool in the medical field. The process of accurately diagnosing a biopsy sample requires significant expertise in the field, and as such can be…

Image and Video Processing · Electrical Eng. & Systems 2019-09-24 Alison K. Cheeseman , Hamid Tizhoosh , Edward R. Vrscay

Accurate detection of cancer tissue regions (CTR) enables deeper analysis of the tumor microenvironment and offers crucial insights into treatment response. Traditional CTR detection methods, which typically rely on the rich cellular…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Shuailin Xue , Jun Wan , Lihua Zhang , Wenwen Min

Automated Lymph Node (LN) detection is an important clinical diagnostic task but very challenging due to the low contrast of surrounding structures in Computed Tomography (CT) and to their varying sizes, poses, shapes and sparsely…

Computer Vision and Pattern Recognition · Computer Science 2015-09-17 Holger R. Roth , Le Lu , Ari Seff , Kevin M. Cherry , Joanne Hoffman , Shijun Wang , Jiamin Liu , Evrim Turkbey , Ronald M. Summers

Molecularly targeted contrast enhanced ultrasound (mCEUS) is a clinically promising approach for early cancer detection through targeted imaging of VEGFR2 (KDR) receptors. We have developed computational enhancement techniques for mCEUS…

Image and Video Processing · Electrical Eng. & Systems 2020-06-23 Andrew A. Berlin , Mon Young , Ahmed El Kaffas , Sam Gambhir , Amelie Lutz , Maria Luigia Storto , Juergen Willmann