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Alzheimer's disease is a progressive neurodegenerative disorder in which mild cognitive impairment (MCI) marks a critical transition between aging and dementia. Neuroimaging modalities, such as structural MRI, provide biomarkers of this…

Machine Learning · Computer Science 2026-03-02 Vrushank Ahire , Yogesh Kumar , Anouck Girard , M. A. Ganaie

Multi-site MRI studies often suffer from site-specific variations arising from differences in methodology, hardware, and acquisition protocols, thereby compromising accuracy and reliability in clinical AI/ML tasks. We present PRISM…

Image and Video Processing · Electrical Eng. & Systems 2024-11-12 Sarang Galada , Tanurima Halder , Kunal Deo , Ram P Krish , Kshitij Jadhav

Purpose: To develop a general framework for Parallel Imaging (PI) with the use of Maxwell regularization for the estimation of the sensitivity maps (SMs) and constrained optimization for the parameter-free image reconstruction. Theory and…

Image and Video Processing · Electrical Eng. & Systems 2020-08-21 Matteo Alessandro Francavilla , Stamatios Lefkimmiatis , Jorge F. Villena , Athanasios G. Polimeridis

Schizophrenia is a chronic neuropsychiatric disorder that causes distinct structural alterations within the brain. We hypothesize that deep learning applied to a structural neuroimaging dataset could detect disease-related alteration and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-08 Junhao Zhang , Vishwanatha M. Rao , Ye Tian , Yanting Yang , Nicolas Acosta , Zihan Wan , Pin-Yu Lee , Chloe Zhang , Lawrence S. Kegeles , Scott A. Small , Jia Guo

Deep learning has shown remarkable progress in medical image semantic segmentation, yet its success heavily depends on large-scale expert annotations and consistent data distributions. In practice, annotations are scarce, and images are…

Computer Vision and Pattern Recognition · Computer Science 2026-01-26 Ba-Thinh Lam , Thanh-Huy Nguyen , Hoang-Thien Nguyen , Quang-Khai Bui-Tran , Nguyen Lan Vi Vu , Phat K. Huynh , Ulas Bagci , Min Xu

Traditional supervised medical image segmentation models require large amounts of labeled data for training; however, obtaining such large-scale labeled datasets in the real world is extremely challenging. Recent semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Yunyao Lu , Yihang Wu , Reem Kateb , Ahmad Chaddad

Developing successful artificial intelligence systems in practice depends on both robust deep learning models and large, high-quality data. However, acquiring and labeling data can be prohibitively expensive and time-consuming in many…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Saba Dadsetan , Mohsen Hejrati , Shandong Wu , Somaye Hashemifar

A plethora of machine learning methods have been applied to imaging data, enabling the construction of clinically relevant imaging signatures of neurological and neuropsychiatric diseases. Oftentimes, such methods don't explicitly model the…

Machine Learning · Computer Science 2022-05-11 Zhijian Yang , Junhao Wen , Christos Davatzikos

The ability to classify images is dependent on having access to large labeled datasets and testing on data from the same domain that the model can train on. Classification becomes more challenging when dealing with new data from a different…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Firas Al-Hindawi , Md Mahfuzur Rahman Siddiquee , Teresa Wu , Han Hu , Ying Sun

Skull stripping is a crucial prerequisite step in the analysis of brain magnetic resonance images (MRI). Although many excellent works or tools have been proposed, they suffer from low generalization capability. For instance, the model…

Image and Video Processing · Electrical Eng. & Systems 2022-12-26 Yunxiang Li , Ruilong Dan , Shuai Wang , Yifan Cao , Xiangde Luo , Chenghao Tan , Gangyong Jia , Huiyu Zhou , You Zhang , Yaqi Wang , Li Wang

Self-supervised learning (SSL) has recently achieved promising performance for 3D medical image analysis tasks. Most current methods follow existing SSL paradigm originally designed for photographic or natural images, which cannot…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Yankai Jiang , Mingze Sun , Heng Guo , Xiaoyu Bai , Ke Yan , Le Lu , Minfeng Xu

Deep learning models for medical image segmentation often struggle when deployed across different datasets due to domain shifts - variations in both image appearance, known as style, and population-dependent anatomical characteristics,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Hoda Kalabizadeh , Ludovica Griffanti , Pak-Hei Yeung , Ana I. L. Namburete , Nicola K. Dinsdale , Konstantinos Kamnitsas

Medical Image Segmentation (MIS) plays a crucial role in medical therapy planning and robot navigation. Prototype learning methods in MIS focus on generating segmentation masks through pixel-to-prototype comparison. However, current…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Zhe Wang , Chang Yao

Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide, necessitating early and accurate diagnosis for optimal patient management. In recent years, advancements in deep learning have shown remarkable potential…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Taymaz Akan , Sait Alp , Md. Shenuarin Bhuiyan , Elizabeth A. Disbrow , Steven A. Conrad , John A. Vanchiere , Christopher G. Kevil , Mohammad A. N. Bhuiyan

Volumetric neuroimaging examinations like structural Magnetic Resonance Imaging (sMRI) are routinely applied to support the clinical diagnosis of dementia like Alzheimer's Disease (AD). Neuroradiologists examine 3D sMRI to detect and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Lisa Anita De Santi , Jörg Schlötterer , Meike Nauta , Vincenzo Positano , Christin Seifert

Medical images like CT and MRI provide detailed information about the internal structure of the body, and identifying key anatomical structures from these images plays a crucial role in clinical workflows. Current methods treat it as a…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Xiaoyu Bai , Yong Xia

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the accumulation of amyloid-beta (A$\beta$) and phosphorylated tau (p-tau) proteins, leading to cognitive decline measured by the Alzheimer's Disease…

Neurons and Cognition · Quantitative Biology 2025-04-21 Swadesh Pal , Roderick Melnik

Deep learning has shown outstanding performance in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated…

Image and Video Processing · Electrical Eng. & Systems 2019-08-22 Taeho Jo , Kwangsik Nho , Andrew J. Saykin

Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial Network), a novel semi-supervised deep-clustering method, which dissects…

The primary motivation and application in this article come from brain imaging studies on cognitive impairment in elderly subjects with brain disorders. We propose a regularized Haar wavelet-based approach for the analysis of…

Applications · Statistics 2014-08-11 Xuejing Wang , Bin Nan , Ji Zhu , Robert Koeppe
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