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The human brain is a complex network of interconnected brain regions organized into functional modules with distinct roles in cognition and behavior. An important question concerns the persistence and stability of these modules over the…
The human brain is organized as a complex network, where connections between regions are characterized by both functional connectivity (FC) and structural connectivity (SC). While previous studies have primarily focused on network-level…
The brain's structural connectome supports signal propagation between neuronal elements, shaping diverse coactivation patterns that can be captured as functional connectivity. While the link between structure and function remains an ongoing…
The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected…
Volumetric brain reconstructions provide an unprecedented opportunity to gain insights into the complex connectivity patterns of neurons in an increasing number of organisms. Here, we model and quantify the complexity of the resulting…
The aim of this paper is to give an overview of brain organoid computing, its characteristics, challenges, as well as possible advantages for future applications in the field of artificial intelligence. An important part is the extensive…
The human brain has long inspired the pursuit of artificial intelligence (AI). Recently, neuroimaging studies provide compelling evidence of alignment between the computational representation of artificial neural networks (ANNs) and the…
Structured populations are ubiquitous across the biological sciences. Mathematical models of these populations allow us to understand how individual physiological traits drive the overall dynamics in aggregate. For example, linear age- or…
Understanding the mechanics of brain embryogenesis can provide insights on pathologies related to brain development, such as lissencephaly, a genetic disease which cause a reduction of the number of cerebral sulci. Recent experiments on…
The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…
Neuronal circuits of the cerebral cortex are the structural basis of mammalian cognition. The same qualitative components and connectivity motifs are repeated across functionally specialized cortical areas and mammalian species, suggesting…
Living neural networks emerge through a process of growth and self-organization that begins with a single cell and results in a brain, an organized and functional computational device. Artificial neural networks, however, rely on…
Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…
Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…
In a cell or microorganism the processes that generate mass, energy, information transfer, and cell fate specification are seamlessly integrated through a complex network of various cellular constituents and reactions. However, despite the…
Recent developments in network neuroscience have highlighted the importance of developing techniques for analyzing and modeling brain networks. A particularly powerful approach for studying complex neural systems is to formulate generative…
Diverse cognitive processes set different demands on locally segregated and globally integrated brain activity. However, it remains unclear how resting brains configure their functional organization to balance the demands on network…
Migratory and tissue resident cells exhibit highly branched morphologies to perform their function and to adapt to the microenvironment. Immune cells, for example, display transient branched shapes while exploring the surrounding tissues.…
We introduce a general theoretical framework to study the shape dynamics of actively growing and remodeling surfaces. Using this framework we develop a physical model for growing bacterial cell walls and study the interplay of cell shape…
Cognitive processes in the brain, like learning, formation of memory, recovery of memorized images, classification of objects have two features: First, there is no supervisor in the brain who controls these processes. Second there is a hugh…