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Reinforcement learning (RL) has recently shown promise in predicting Alzheimer's disease (AD) progression due to its unique ability to model domain knowledge. However, it is not clear which RL algorithms are well-suited for this task.…

This paper addresses classification problems with matrix-valued data, which commonly arise in applications such as neuroimaging and signal processing. Building on the assumption that the data from each class follows a matrix normal…

Methodology · Statistics 2025-12-18 Seungyeon Oh , Seongoh Park , Hoyoung Park

Alzheimer's disease (AD) is one of the most common public health issues the world is facing today. This disease has a high prevalence primarily in the elderly accompanying memory loss and cognitive decline. AD detection is a challenging…

Image and Video Processing · Electrical Eng. & Systems 2022-04-04 Zahraa Sh. Aaraji , Hawraa H. Abbas

Alzheimer's Disease (AD) is the most prevalent neurodegenerative disorder in aging populations, posing a significant and escalating burden on global healthcare systems. While Multi-Tusk Learning (MTL) has emerged as a powerful computational…

Machine Learning · Computer Science 2025-10-14 Zixiang Xu , Menghui Zhou , Jun Qi , Xuanhan Fan , Yun Yang , Po Yang

Stacking, a potent ensemble learning method, leverages a meta-model to harness the strengths of multiple base models, thereby enhancing prediction accuracy. Traditional stacking techniques typically utilize established learning models, such…

Machine Learning · Computer Science 2024-10-31 Wei Wu , Liang Tang , Zhongjie Zhao , Chung-Piaw Teo

Exploiting different representations, or views, of the same object for better clustering has become very popular these days, which is conventionally called multi-view clustering. Generally, it is essential to measure the importance of each…

Machine Learning · Computer Science 2019-06-24 Feiping Nie , Jing Li , Xuelong Li

For a medical diagnosis, health professionals use different kinds of pathological ways to make a decision for medical reports in terms of patients medical condition. In the modern era, because of the advantage of computers and technologies,…

Machine Learning · Statistics 2021-06-08 Fahad B. Mostafa , Md Easin Hasan

Many biomedical studies collect high-dimensional medical imaging data to identify biomarkers for the detection, diagnosis, and treatment of human diseases. Consequently, it is crucial to develop accurate models that can predict a wide range…

Methodology · Statistics 2025-05-05 Yue Wang , Xiao Wang , Joseph G. Ibrahim , Hongtu Zhu

In the era of rapidly advancing medical technologies, the segmentation of medical data has become inevitable, necessitating the development of privacy preserving machine learning algorithms that can train on distributed data. Consolidating…

Machine Learning · Computer Science 2024-09-30 Paul K. Mandal

Deep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of healthcare. This study focuses on…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Nida Nasir , Muneeb Ahmed , Neda Afreen , Mustafa Sameer

The transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is of great interest to clinical researchers. This phenomenon also serves as a valuable data source for quantitative methodological researchers developing new…

Applications · Statistics 2020-12-02 Zihuan Liu , Tapabrate Maiti , Andrew R. Bender

Accurately discriminating progressive stages of Alzheimer's Disease (AD) is crucial for early diagnosis and prevention. It often involves multiple imaging modalities to understand the complex pathology of AD, however, acquiring a complete…

Image and Video Processing · Electrical Eng. & Systems 2025-03-06 Seunghun Baek , Jaeyoon Sim , Guorong Wu , Won Hwa Kim

Timely and accurate diagnosis of neurodegenerative disorders, such as Alzheimer's disease, is central to disease management. Existing deep learning models require large-scale annotated datasets and often function as "black boxes".…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Duy-Cat Can , Quang-Huy Tang , Huong Ha , Binh T. Nguyen , Oliver Y. Chén

Healthcare datasets present many challenges to both machine learning and statistics as their data are typically heterogeneous, censored, high-dimensional and have missing information. Feature selection is often used to identify the…

Machine Learning · Computer Science 2022-07-06 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Dementia is a complex syndrome impacting cognitive and emotional functions, with Alzheimer's disease being the most common form. This study focuses on enhancing dementia prediction using machine learning (ML) techniques on patient health…

Artificial Intelligence · Computer Science 2026-01-13 Shafiul Ajam Opee , Nafiz Fahad , Anik Sen , Rasel Ahmed , Fariha Jahan , Md. Kishor Morol , Md Rashedul Islam

Cognitive distortions have been closely linked to mental health disorders, yet their automatic detection remains challenging due to contextual ambiguity, co-occurrence, and semantic overlap. We propose a novel framework that combines Large…

Computation and Language · Computer Science 2026-04-20 Jun Seo Kim , Hyemi Kim , Woo Joo Oh , Hongjin Cho , Hochul Lee , Hye Hyeon Kim

Multi-view feature has been proved to be very effective in many multimedia applications. However, the current back-end classifiers cannot make full use of such features. In this paper, we propose a method to model the multi-faceted…

Machine Learning · Computer Science 2017-07-10 Ziqiang Shi , Liu Liu , Mengjiao Wang , Rujie Liu

Early diagnosis of Alzheimer's disease is a challenge because the existing methodologies do not identify the patients in their preclinical stage, which can last up to a decade prior to the onset of clinical symptoms. Several research…

Machine Learning · Computer Science 2024-01-03 Vivek Kumar Tiwari , Premananda Indic , Shawana Tabassum

Alzheimer's disease (AD) is a heterogeneous, multifactorial neurodegenerative disorder characterized by beta-amyloid, pathologic tau, and neurodegeneration. There are no effective treatments for Alzheimer's disease at a late stage, urging…

Quantitative Methods · Quantitative Biology 2023-08-28 Enze Xu , Jingwen Zhang , Jiadi Li , Qianqian Song , Defu Yang , Guorong Wu , Minghan Chen

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan