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Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…

Tissues and Organs · Quantitative Biology 2019-07-16 Joe Eyles , John F. King , Vanessa Styles

Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in the development of mathematical models capable of capturing…

Populations and Evolution · Quantitative Biology 2025-04-10 Chiara Villa , Philip K Maini , Alexander P Browning , Adrianne L Jenner , Sara Hamis , Tyler Cassidy

The paper treats a reaction-diffusion equation with hysteretic nonlinearity on a one-dimensional lattice. It arises as a result of the spatial discretization of the corresponding continuous model with so-called nontransverse initial data…

Analysis of PDEs · Mathematics 2016-01-22 Pavel Gurevich , Sergey Tikhomirov

Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or…

Computational Physics · Physics 2016-03-02 Fabian Spill , Pilar Guerrero , Tomas Alarcon , Philip K. Maini , Helen Byrne

In the present work, we investigate a model of the invasion of healthy tissue by cancer cells which is described by a system of nonlinear PDEs consisting of a cross-diffusion-reaction equation and two additional nonlinear ordinary…

Numerical Analysis · Mathematics 2023-07-18 Shahin Heydari , Petr Knobloch , Thoma Wick

Reaction-diffusion equations appear in biology and chemistry, and combine linear diffusion with different kind of reaction terms. Some of them are remarkable from the mathematical point of view, since they admit families of travelling waves…

Analysis of PDEs · Mathematics 2019-01-14 Alessandro Audrito

This paper deals with the large time dynamics of bounded solutions of reaction-diffusion equations with unbounded initial support in $\mathbb{R}^N$. We prove a variational formula for the spreading speeds in any direction, and we also…

Analysis of PDEs · Mathematics 2023-07-08 François Hamel , Luca Rossi

Partial differential equation (PDE) models for infectious disease have received renewed interest in recent years. Most models of this type extend classical compartmental formulations with additional terms accounting for spatial dynamics,…

Populations and Evolution · Quantitative Biology 2025-04-29 Pierluigi Colli , Gabriela Marinoschi , Elisabetta Rocca , Alex Viguerie

We construct solutions of nonlinear reaction-diffusion equations with nonlinear boundary conditions in spaces where the problem is supercritical and show the nonlinear balance required between the nonlinear terms in order to obtain a…

Analysis of PDEs · Mathematics 2012-05-22 Aníbal Rodríguez-Bernal , Alejandro Vidal-López

We study existence and uniqueness of travelling fronts, and asymptotic speed of propagation for a non local reaction diffusion equation with spatial and genetic trait structure.

Analysis of PDEs · Mathematics 2014-12-23 Henri Berestycki , Tianling Jin , Luis Silvestre

Reaction-diffusion equations are widely used as the governing evolution equations for modeling many physical, chemical, and biological processes. Here we derive reaction-diffusion equations to model transport with reactions on a…

Statistical Mechanics · Physics 2020-09-16 E. Abad , C. N. Angstmann , B. I. Henry , A. V. McGann , F. Le Vot , S. B. Yuste

Normal and anomalous diffusion are ubiquitous in many complex systems [1] . Here, we define a time and space generalized diffusion equation (GDE), which uses fractional-time derivatives and transformed d-path Laplacian operators on…

Physics and Society · Physics 2022-02-02 Fernando Diaz-Diaz , Ernesto Estrada

A wide class of nonlinear dispersive wave equations are shown to possess a novel type of peakon solution in which the amplitude and speed of the peakon are time-dependent. These novel dynamical peakons exhibit a wide variety of different…

Mathematical Physics · Physics 2019-08-01 Stephen C. Anco , Elena Recio

We study an optimal control problem for a stochastic model of tumour growth with drug application. This model consists of three stochastic hyperbolic equations describing the evolution of tumour cells. It also includes two stochastic…

Optimization and Control · Mathematics 2024-08-30 Sakine Esmaili , M. R. Eslahchi , Delfim F. M. Torres

We study the front propagation in Reaction-Diffusion systems whose reaction dynamics exhibits an unstable fixed point and chaotic or noisy behaviour. We have examined the influence of chaos and noise on the front propagation speed and on…

Statistical Mechanics · Physics 2009-11-07 Alessandro Torcini , Angelo Vulpiani , Andrea Rocco

Many mathematical models for biological phenomena, such as the spread of diseases, are based on reaction-diffusion equations for densities of interacting cell populations. We present a consistent derivation of reaction-diffusion equations…

Analysis of PDEs · Mathematics 2026-02-23 Marzia Bisi , Davide Cusseddu , Ana Jacinta Soares , Romina Travaglini

In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…

Biological Physics · Physics 2023-02-07 Maxim V. Polyakov , Valeria V. Ten

We discuss numerical aspects related to a new class of nonlinear Stochastic Differential Equations in the sense of McKean, which are supposed to represent non conservative nonlinear Partial Differential equations (PDEs). We propose an…

Probability · Mathematics 2016-08-03 Anthony Le Cavil , Nadia Oudjane , Francesco Russo

We study nonlinear stability of spatially homogeneous oscillations in reaction-diffusion systems. Assuming absence of unstable linear modes and linear diffusive behavior for the neutral phase, we prove that spatially localized perturbations…

Analysis of PDEs · Mathematics 2008-07-01 Thierry Gallay , Arnd Scheel

This paper investigates the well-posedness and small-noise asymptotics of a class of stochastic partial differential equations defined on a bounded domain of $\mathbb{R}^d$, where the diffusion coefficient depends nonlinearly and…

Probability · Mathematics 2025-06-23 Sandra Cerrai , Giuseppina Guatteri , Gianmario Tessitore