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In an earlier paper, we proved the validity of large deviations theory for the particle approximation of quite general chemical reaction networks (CRNs). In this paper, we extend its scope and present a more geometric insight into the…

Dynamical Systems · Mathematics 2018-08-01 Andrea Agazzi , Amir Dembo , Jean-Pierre Eckmann

We investigate a broad family of chemical reaction networks (CRNs) assigned with mass action kinetics, called complex-balanced-produced-CRNs (CBP-CRNs), which are generated by any given complex balanced mass action system (MAS) and whose…

Dynamical Systems · Mathematics 2019-11-12 Shan Wu , Yafei Lu , Chuanhou Gao

Much of the theory on chemical-reaction networks (CRNs) has been developed in the ideal-solution limit, where interactions between the solutes are negligible. However, there is a large variety of phenomena in biological cells and…

Biological Physics · Physics 2022-12-09 Ander Movilla Miangolarra , Michele Castellana

The approximation of solutions to second order Hamilton--Jacobi--Bellman (HJB) equations by deep neural networks is investigated. It is shown that for HJB equations that arise in the context of the optimal control of certain Markov…

Numerical Analysis · Mathematics 2021-03-11 Philipp Grohs , Lukas Herrmann

We present a framework to transform the problem of finding a Lyapunov function of a Chemical Reaction Network (CRN) in concentration coordinates with arbitrary monotone kinetics into finding a common Lyapunov function for a linear parameter…

Optimization and Control · Mathematics 2017-10-31 M. Ali Al-Radhawi , David Angeli

We obtain bounds on the Kullback--Leibler divergence to equilibrium for mass-action chemical reaction networks (CRNs) with equilibrium. The associated decay rates are characterized in terms of the singular values of the stoichiometric…

Molecular Networks · Quantitative Biology 2026-02-24 Keisuke Sugie , Dimitri Loutchko , Tetsuya J. Kobayashi

Piecewise-Linear in Rates (PWLR) Lyapunov functions are introduced for a class of Chemical Reaction Networks (CRNs). In addition to their simple structure, these functions are robust with respect to arbitrary monotone reaction rates, of…

Optimization and Control · Mathematics 2016-09-09 M. Ali Al-Radhawi , David Angeli

Analysis of large continuous-time stochastic systems is a computationally intensive task. In this work we focus on population models arising from chemical reaction networks (CRNs), which play a fundamental role in analysis and design of…

Systems and Control · Computer Science 2019-05-27 Milan Češka , Jan Křetínský

Wigner's jellium is a model for a gas of electrons. The model consists of $N$ unit negatively charged particles lying in a sea of neutralizing homogeneous positive charge spread out according to Lebesgue measure, and interactions are…

Probability · Mathematics 2022-07-20 Christian Hirsch , Sabine Jansen , Paul Jung

Continuous-time reinforcement learning offers an appealing formalism for describing control problems in which the passage of time is not naturally divided into discrete increments. Here we consider the problem of predicting the distribution…

Machine Learning · Computer Science 2022-06-20 Harley Wiltzer , David Meger , Marc G. Bellemare

Chemical reaction networks (CRNs) are foundational models for describing complex biochemical processes. We study noncompetitive CRNs, a class of networks whose static states are rate-independent, and that can implement ReLU neural networks.…

Molecular Networks · Quantitative Biology 2025-12-22 Louis Faul , Xavier Richard , Mary Betrisey , Christian Mazza

The purpose of this paper is to describe the numerical solution of the Hamilton-Jacobi-Bellman (HJB) for an optimal control problem for quantum spin systems. This HJB equation is a first order nonlinear partial differential equation defined…

Quantum Physics · Physics 2011-10-05 Srinivas Sridharan , Matthew R. James

In this paper we establish periodic homogenization for Hamilton-Jacobi-Bellman (HJB) equations, associated to nonlocal operators of integro-differential type. We consider the case when the fractional diffusion has the same order as the…

Analysis of PDEs · Mathematics 2020-02-24 Adina Ciomaga , Daria Ghilli , Erwin Topp

We prove a sample path Large Deviation Principle (LDP) for a class of jump processes whose rates are not uniformly Lipschitz continuous in phase space. Building on it we further establish the corresponding Wentzell-Freidlin (W-F) (infinite…

Probability · Mathematics 2017-10-24 Andrea Agazzi , Amir Dembo , Jean-Pierre Eckmann

Chemical reaction networks (CRN) comprise an important class of models to understand biological functions such as cellular information processing, the robustness and control of metabolic pathways, circadian rhythms, and many more. However,…

Molecular Networks · Quantitative Biology 2025-03-25 Dimitri Loutchko , Yuki Sughiyama , Tetsuya J. Kobayashi

Chemical reactions can be modeled by a random time-changed Poisson process on countable states. The macroscopic behaviors, such as large fluctuations, can be studied via the WKB reformulation. The WKB reformulation for the backward equation…

Analysis of PDEs · Mathematics 2023-06-07 Yuan Gao , Jian-Guo Liu

The study of the dynamics of chemical reactions, and in particular phenomena such as oscillating reactions, has led to the recognition that many dynamical properties of a chemical reaction can be predicted from graph theoretical properties…

Dynamical Systems · Mathematics 2022-11-08 J. J. P. Veerman , Tessa Whalen-Wagner , Ewan Kummel

We study the macroscopic behavior of chemical reactions modeled as random time-changed Poisson processes on discrete state spaces. Using the WKB reformulation, the backward equation of the rescaled process leads to a discrete…

Analysis of PDEs · Mathematics 2025-09-26 Yuan Gao , Yuxi Han

The framework of deep operator network (DeepONet) has been widely exploited thanks to its capability of solving high dimensional partial differential equations. In this paper, we incorporate DeepONet with a recently developed policy…

Optimization and Control · Mathematics 2024-06-18 Jae Yong Lee , Yeoneung Kim

We study the solution theory of the whole-space static (elliptic) Hamilton-Jacobi-Bellman (HJB) equation in spectral Barron spaces. We prove that under the assumption that the coefficients involved are spectral Barron functions and the…

Analysis of PDEs · Mathematics 2025-09-18 Ye Feng , Jianfeng Lu
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