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The rapid integration of machine learning methodologies in healthcare has ignited innovative strategies for disease prediction, particularly with the vast repositories of Electronic Health Records (EHR) data. This article delves into the…

Machine Learning · Computer Science 2024-08-07 D. Dhinakaran , S. Edwin Raja , M. Thiyagarajan , J. Jeno Jasmine , P. Raghavan

Healthcare datasets often contain groups of highly correlated features, such as features from the same biological system. When feature selection is applied to these datasets to identify the most important features, the biases inherent in…

Machine Learning · Computer Science 2022-07-07 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Traditional model-free feature selection methods treat each feature independently while disregarding the interrelationships among features, which leads to relatively poor performance compared with the model-aware methods. To address this…

Machine Learning · Computer Science 2025-06-10 Jianming Lv , Sijun Xia , Depin Liang , Wei Chen

Deep learning has significantly advanced automatic medical diagnostics and released the occupation of human resources to reduce clinical pressure, yet the persistent challenge of data scarcity in this area hampers its further improvements…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Zehui Zhao , Laith Alzubaidi , Jinglan Zhang , Ye Duan , Usman Naseem , Yuantong Gu

Evolutionary computation (EC) algorithms, such as discrete and multi-objective versions of particle swarm optimization (PSO), have been applied to solve the Feature selection (FS) problem, tackling the combinatorial explosion of search…

Neural and Evolutionary Computing · Computer Science 2019-01-28 Hassen Dhrif , Luis G. Sanchez Giraldo , Miroslav Kubat , Stefan Wuchty

Feature selection (FS) has become an indispensable task in dealing with today's highly complex pattern recognition problems with massive number of features. In this study, we propose a new wrapper approach for FS based on binary…

Machine Learning · Statistics 2016-03-08 Vural Aksakalli , Milad Malekipirbazari

Detailed phenotype information is fundamental to accurate diagnosis and risk estimation of diseases. As a rich source of phenotype information, electronic health records (EHRs) promise to empower diagnostic variant interpretation. However,…

Machine Learning · Computer Science 2023-04-28 Shenghan Zhang , Haoxuan Li , Ruixiang Tang , Sirui Ding , Laila Rasmy , Degui Zhi , Na Zou , Xia Hu

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

Deep learning is a kind of feature learning method with strong nonliear feature transformation and becomes more and more important in many fields of artificial intelligence. Deep autoencoder is one representative method of the deep learning…

Machine Learning · Computer Science 2020-02-18 Yongming Li , Yan Lei , Pin Wang , Yuchuan Liu

This paper proposes a non-interactive end-to-end solution for secure fusion and matching of biometric templates using fully homomorphic encryption (FHE). Given a pair of encrypted feature vectors, we perform the following ciphertext…

Computer Vision and Pattern Recognition · Computer Science 2022-08-16 Luke Sperling , Nalini Ratha , Arun Ross , Vishnu Naresh Boddeti

Accurately identifying cancer samples is crucial for precise diagnosis and effective patient treatment. Traditional methods falter with high-dimensional and high feature-to-sample count ratios, which are critical for classifying cancer…

Machine Learning · Computer Science 2025-01-14 Tareque Mohmud Chowdhury , Farzana Tabassum , Sabrina Islam , Abu Raihan Mostofa Kamal

Predicting spatial gene expression from H&E histology offers a scalable and clinically accessible alternative to sequencing, but realizing clinical impact requires models that generalize across cancer types and capture biologically coherent…

Machine Learning · Computer Science 2026-02-10 Susu Hu , Qinghe Zeng , Nithya Bhasker , Jakob Nikolas Kather , Stefanie Speidel

Increasing volume of Electronic Health Records (EHR) in recent years provides great opportunities for data scientists to collaborate on different aspects of healthcare research by applying advanced analytics to these EHR clinical data. A…

Machine Learning · Computer Science 2019-10-01 Najibesadat Sadati , Milad Zafar Nezhad , Ratna Babu Chinnam , Dongxiao Zhu

Analyzing data from multiple sources offers valuable opportunities to improve the estimation efficiency of causal estimands. However, this analysis also poses many challenges due to population heterogeneity and data privacy constraints.…

Methodology · Statistics 2025-10-23 Rong Zhao , Jason Falvey , Xu Shi , Vernon M. Chinchilli , Chixiang Chen

Increasing volume of Electronic Health Records (EHR) in recent years provides great opportunities for data scientists to collaborate on different aspects of healthcare research by applying advanced analytics to these EHR clinical data. A…

Machine Learning · Computer Science 2019-09-23 Najibesadat Sadati , Milad Zafar Nezhad , Ratna Babu Chinnam , Dongxiao Zhu

Feature selection is a process of choosing a subset of relevant features so that the quality of prediction models can be improved. An extensive body of work exists on information-theoretic feature selection, based on maximizing Mutual…

Machine Learning · Computer Science 2016-12-05 Jilin Wu , Soumyajit Gupta , Chandrajit Bajaj

High-resolution simulation models are essential for representing complex physical systems, yet their substantial computational cost severely limits the number of feasible high-fidelity (HF) evaluations. This problem is often addressed…

Methodology · Statistics 2026-04-21 Hossein Mohammadi

Various approaches to gene selection for cancer classification based on microarray data can be found in the literature and they may be grouped into two categories: univariate methods and multivariate methods. Univariate methods look at each…

Quantitative Methods · Quantitative Biology 2015-06-18 Min Xu , Rudy Setiono

Due to the rapid development of high-throughput experimental techniques and fast-dropping prices, many transcriptomic datasets have been generated and accumulated in the public domain. Meta-analysis combining multiple transcriptomic studies…

Applications · Statistics 2019-05-17 Zhiguang Huo , Chi Song , George Tseng

Spatial transcriptomics enables interrogating the molecular composition of tissue with ever-increasing resolution and sensitivity. However, costs, rapidly evolving technology, and lack of standards have constrained computational methods in…