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In this paper we consider a free boundary tumor growth model with a time delay in cell proliferation and study how time delay affects the stability and the size of the tumor. The model is a coupled system of an elliptic equation, a…

Analysis of PDEs · Mathematics 2019-08-20 Xinyue Evelyn Zhao , Bei Hu

This paper is concerned with a multi-dimensional free boundary problem modeling the growth of a tumor with two species of cells: proliferating cells and quiescent cells. This free boundary problem has a unique radial stationary solution. By…

Analysis of PDEs · Mathematics 2015-06-17 Shangbin Cui

We consider a free boundary tumor model under the presence of angiogenesis and time delays in the process of proliferation, in which the cell location is incorporated. It is assumed that the tumor attracts blood vessels at a rate…

Analysis of PDEs · Mathematics 2021-03-09 Zejia Wang , Haihua Zhou , Huijuan Song

In this paper, we consider a 3-dimensional free boundary problem modeling tumor growth with the Robin boundary condition. The system involves a positive parameter $\mu$ which reflects the intensity of tumor aggressiveness. Huang, Zhang and…

Analysis of PDEs · Mathematics 2026-01-23 Junying Chen , Ruixiang Xing

In this paper we study a free boundary problem for the growth of multi-layer tumors in necrotic phase. The tumor region is strip-like and divided into necrotic region and proliferating region with two free boundaries. The upper free…

Analysis of PDEs · Mathematics 2019-09-04 Junde Wu

We study a free boundary problem modeling tumor growth with a T-periodic supply $\Phi(t)$ of external nutrients. The model contains two parameters $\mu$ and $\widetilde{\sigma}$. We first show that (i) zero radially symmetric solution is…

Analysis of PDEs · Mathematics 2020-09-29 Wenhua He , Ruixiang Xing

In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or…

Analysis of PDEs · Mathematics 2013-06-11 Martin Kohlmann

This paper aims at proving asymptotic stability of the radial stationary solution of a free boundary problem modeling the growth of nonnecrotic tumors with fluid-like tissues. In a previous paper we considered the case where the nutrient…

Analysis of PDEs · Mathematics 2008-06-10 Junde Wu , Shangbin Cui

In this paper we study a free boundary problem modeling the growth of solid tumor spheroid. It consists of two elliptic equations describing nutrient diffusion and pressure distribution within tumor, respectively. The new feature is that…

Analysis of PDEs · Mathematics 2016-12-01 Junde Wu , Fujun Zhou

In this paper, we study a free boundary problem modeling solid tumor growth with vasculature which supplies nutrients to the tumor; this is characterized in the Robin boundary condition. It was recently established [Discrete Cont. Dyn.…

Analysis of PDEs · Mathematics 2020-07-15 Yaodan Huang , Zhengce Zhang , Bei Hu

For tumor growth, the morphological instability provides a mechanism for invasion via tumor fingering and fragmentation. This work considers the asymptotic stability of a free boundary tumor model with a periodic supply of external…

Analysis of PDEs · Mathematics 2021-10-01 Yaodan Huang

The present paper deals with a free boundary problem modeling the growth process of necrotic multi-layer tumors. We prove the existence of flat stationary solutions and determine the linearization of our model at such an equilibrium.…

Analysis of PDEs · Mathematics 2012-09-18 Martin Kohlmann

This paper studies asymptotic behavior of solutions of a free boundary problem modeling the growth of tumors with two species of cells: proliferating cells and quiecent cells. In previous literatures it has been proved that this problem has…

Analysis of PDEs · Mathematics 2013-03-18 Shangbin Cui

We study a free boundary problem modelling the growth of non-necrotic tumors with fluid-like tissues. The fluid velocity satisfies Stokes equations with a source determined by the proliferation rate of tumor cells which depends on the…

Analysis of PDEs · Mathematics 2008-06-10 Junde Wu , Shangbin Cui

A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…

Analysis of PDEs · Mathematics 2012-04-12 Martin Kohlmann

In this paper we study asymptotic behavior of solutions for a multidimensional free boundary problem modelling the growth of nonnecrotic tumors. We first establish a general result for differential equations in Banach spaces possessing a…

Analysis of PDEs · Mathematics 2007-12-18 Shangbin Cui

In this paper we study a nonlinear free boundary problem on the radial growth of a two-layer solid tumor with a quiescent core. The tumor surface and its inner interface separating the proliferating cells and the quiescent cells are both…

Analysis of PDEs · Mathematics 2025-01-09 Junde Wu , Hao Xu , Yuehong Zhuang

In this paper, we present a rigorous mathematical analysis of a free boundary problem modeling the growth of a vascular solid tumor with a necrotic core. If the vascular system supplies the nutrient concentration $\sigma$ to the tumor at a…

Analysis of PDEs · Mathematics 2019-09-20 Huijuan Song , Bei Hu , Zejia Wang

This paper concerns a free boundary problem modeling tumor growth with angiogenesis and two time delays. The two delays represent the time taken for cells to undergo mitosis and modify the rate of cell loss because of apoptosis,…

Analysis of PDEs · Mathematics 2022-01-05 Haihua Zhou , Zejia Wang , Daming Yuan , Huijuan Song

In this paper we study asymptotic behavior of solutions for a free boundary problem modeling the growth of tumors containing two species of cells: proliferating cells and quiescent cells. This tumor model was proposed by Pettet et al in…

Analysis of PDEs · Mathematics 2007-12-18 Shangbin Cui
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