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Many complex diseases are known to be affected by the interactions between genetic variants and environmental exposures beyond the main genetic and environmental effects. Study of gene-environment (G$\times$E) interactions is important for…

Methodology · Statistics 2019-10-01 Jie Ren , Fei Zhou , Xiaoxi Li , Qi Chen , Hongmei Zhang , Shuangge Ma , Yu Jiang , Cen Wu

Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the…

Methodology · Statistics 2024-03-11 Haodong Tian , Ashish Patel , Stephen Burgess

The use of instrumental variables for estimating the effect of an exposure on an outcome is popular in econometrics, and increasingly so in epidemiology. This increasing popularity may be attributed to the natural occurrence of instrumental…

Methodology · Statistics 2016-08-03 T. Martinussen , S. Vansteelandt , E. J. Tchetgen Tchetgen , D. M. Zucker

Exposure to air pollution is associated with increased morbidity and mortality. Recent technological advancements permit the collection of time-resolved personal exposure data. Such data are often incomplete with missing observations and…

This manuscript presents a novel Bayesian varying coefficient quantile regression (BVCQR) model designed to assess the longitudinal effects of chemical exposure mixtures on children's neurodevelopment. Recognizing the complexity and…

Applications · Statistics 2024-04-22 Wei Jia , Roman Jandarov

Environmental epidemiologic studies routinely utilize aggregate health outcomes to estimate effects of short-term (e.g., daily) exposures that are available at increasingly fine spatial resolutions. However, areal averages are typically…

Applications · Statistics 2023-02-07 Yuzi Zhang , Howard H. Chang , Joshua L. Warren , Stefanie T. Ebelt

Airborne particulate matter (PM2.5) is a major public health concern in urban environments, where population density and emission sources exacerbate exposure risks. We present a novel Bayesian spatiotemporal fusion model to estimate monthly…

Causal mediation analysis is a powerful tool in environmental health research, allowing researchers to uncover the pathways through which exposures influence health outcomes. While traditional mediation methods have been widely applied to…

The Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address whether exposure to levels…

Methodology · Statistics 2020-01-09 Georgia Papadogeorgou , Francesca Dominici

Joint models have proven to be an effective approach for uncovering potentially hidden connections between various types of outcomes, mainly continuous, time-to-event, and binary. Typically, longitudinal continuous outcomes are…

Bayesian methods are increasingly being applied to parameterize mechanistic process models used in environmental prediction and forecasting. In particular, models describing ecosystem dynamics with multiple states that are linear and…

Applications · Statistics 2021-10-19 John W. Smith , Leah R. Johnson , Robert Q. Thomas

The analysis of population-wide datasets can provide insight on the health status of large populations so that public health officials can make data-driven decisions. The analysis of such datasets often requires highly parameterized models…

Applications · Statistics 2021-02-03 Dorota Młynarczyk , Carmen Armero , Virgilio Gómez-Rubio , Pedro Puig

The long duration of the COVID-19 pandemic allowed for multiple bursts in the infection and death rates, the so-called epidemic waves. This complex behavior is no longer tractable by simple compartmental model and requires more…

Describing the complex dependence structure of extreme phenomena is particularly challenging. To tackle this issue we develop a novel statistical algorithm that describes extremal dependence taking advantage of the inherent hierarchical…

Methodology · Statistics 2018-07-24 Sabrina Vettori , Raphaël Huser , Johan Segers , Marc G. Genton

Epidemiologists commonly use regional aggregates of health outcomes to map mortality or incidence rates and identify geographic disparities. However, to detect health disparities across regions, it is necessary to identify "difference…

Methodology · Statistics 2025-05-14 Luca Aiello , Sudipto Banerjee

Estimating the health impacts of exposure to a mixture of chemicals poses many statistical challenges: multiple correlated exposure variables, moderate to high dimensionality, and possible nonlinear and interactive health effects of mixture…

Methodology · Statistics 2025-12-04 Nate Wiecha , Emily Griffith , Brian J. Reich , Jane A. Hoppin

Understanding the sources that contribute to fine particulate matter (PM$_{2.5}$) is of crucial importance for designing and implementing targeted air pollution mitigation strategies. Determining what factors contribute to a pollutant's…

Applications · Statistics 2025-11-03 Michela Frigeri , Veronica Berrocal , Alessandra Guglielmi

In epidemiological disease mapping one aims to estimate the spatio-temporal pattern in disease risk and identify high-risk clusters, allowing health interventions to be appropriately targeted. Bayesian spatio-temporal models are used to…

Methodology · Statistics 2014-11-11 Duncan Lee , Andrew Lawson

Studies have shown that exposure to air pollution, even at low levels, significantly increases mortality. As regulatory actions are becoming prohibitively expensive, robust evidence to guide the development of targeted interventions to…

Applications · Statistics 2018-02-20 Kwonsang Lee , Dylan S. Small , Francesca Dominici

Estimating the causal effects of a spatially-varying intervention on a spatially-varying outcome may be subject to non-local confounding (NLC), a phenomenon that can bias estimates when the treatments and outcomes of a given unit are…

Machine Learning · Computer Science 2022-12-13 Mauricio Tec , James Scott , Corwin Zigler
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