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Numerous biological functions-such as enzymatic catalysis, the immune response system, and the DNA-protein regulatory network-rely on the ability of molecules to specifically recognize target molecules within a large pool of similar…

Molecular Networks · Quantitative Biology 2010-07-27 Yonatan Savir , Tsvi Tlusty

A regularization algorithm using inexact function values and inexact derivatives is proposed and its evaluation complexity analyzed. This algorithm is applicable to unconstrained problems and to problems with inexpensive constraints (that…

Optimization and Control · Mathematics 2019-04-22 S. Bellavia , G. Gurioli , B. Morini , Ph. L. Toint

We develop adaptive discretization algorithms for locally optimal experimental design of nonlinear prediction models. With these algorithms, we refine and improve a pertinent state-of-the-art algorithm in various respects. We establish…

Optimization and Control · Mathematics 2024-06-04 Jochen Schmid , Philipp Seufert , Michael Bortz

This work considers the problem of detecting signals from multiple sequentially observed data streams, where only one stream can be observed at every time instant. The goal is to detect signals as quickly as possible while controlling the…

Methodology · Statistics 2026-04-07 Yiming Xing , Georgios Fellouris

A worst-case complexity bound is proved for a sequential quadratic optimization (commonly known as SQP) algorithm that has been designed for solving optimization problems involving a stochastic objective function and deterministic nonlinear…

Optimization and Control · Mathematics 2022-01-10 Frank E. Curtis , Michael J. O'Neill , Daniel P. Robinson

This paper proposes an algorithmic framework for solving parametric optimization problems which we call adjoint-based predictor-corrector sequential convex programming. After presenting the algorithm, we prove a contraction estimate that…

Optimization and Control · Mathematics 2011-09-14 Q. Tran Dinh , C. Savorgnan , M. Diehl

This contribution considers optimal control problems subject to nonlocal conservation laws -- those in which the velocity depends nonlocally (i.e., via a convolution) on the solution -- and the so-called singular limit. First, the existence…

Optimization and Control · Mathematics 2025-12-22 Alexander Keimer , Lukas Pflug , Jakob Rodestock

In sequential change detection, existing performance measures differ significantly in the way they treat the time of change. By modeling this quantity as a random time, we introduce a general framework capable of capturing and better…

Statistics Theory · Mathematics 2008-12-18 George V. Moustakides

Enabling low power wireless devices to adopt Nyquist sampling at high carriers is prohibitive. In spectrum sensing, this limit calls for an analog front-end that can sweep different bands quickly, in order to use the available spectrum…

Information Theory · Computer Science 2017-12-15 Lorenzo Ferrari , Anna Scaglione

Optimized quantum control can enhance the performance and noise resilience of quantum metrology. However, the optimization quickly becomes intractable when multiple control operations are applied sequentially. In this work, we propose…

Quantum Physics · Physics 2024-12-19 Qiushi Liu , Yuxiang Yang

In a classical optimal stopping problem the aim is to maximize the expected value of a functional of a diffusion evaluated at a stopping time. This note considers optimal stopping problems beyond this paradigm. We study problems in which…

Probability · Mathematics 2017-08-04 Vicky Henderson , David Hobson , Matthew Zeng

We consider the problem of jointly testing multiple hypotheses and estimating a random parameter of the underlying distribution. This problem is investigated in a sequential setup under mild assumptions on the underlying random process. The…

Signal Processing · Electrical Eng. & Systems 2021-05-07 Dominik Reinhard , Michael Fauß , Abdelhak M. Zoubir

Inspired by classical sensitivity results for nonlinear optimization, we derive and discuss new quantitative bounds to characterize the solution map and dual variables of a parametrized nonlinear program. In particular, we derive explicit…

Optimization and Control · Mathematics 2020-06-19 Irina Subotić , Adrian Hauswirth , Florian Dörfler

Given a channel having binary input X = (x_1, x_2) having the probability distribution p_X = (p_{x_1}, p_{x_2}) that is corrupted by a continuous noise to produce a continuous output y \in Y = R. For a given conditional distribution…

Signal Processing · Electrical Eng. & Systems 2020-01-13 Thuan Nguyen , Thinh Nguyen

In pattern mining, sequential rules provide a formal framework to capture the temporal relationships and inferential dependencies between items. However, the discovery process is computationally intensive. To obtain mining results…

Databases · Computer Science 2026-02-20 Wensheng Gan , Gengsen Huang , Junyu Ren , Philip S. Yu

Performance of optimization on quadratic problems sensitively depends on the low-lying part of the spectrum. For large (effectively infinite-dimensional) problems, this part of the spectrum can often be naturally represented or approximated…

Optimization and Control · Mathematics 2024-03-26 Maksim Velikanov , Dmitry Yarotsky

A pivotal task in quantum metrology, and quantum parameter estimation in general, is to de- sign schemes that achieve the highest precision with given resources. Standard models of quantum metrology usually assume the dynamics is fixed, the…

Quantum Physics · Physics 2017-07-18 Jing Liu , Haidong Yuan

State discrimination is a useful test problem with which to clarify the power and limitations of different classes of measurement. We consider the problem of discriminating between given states of a bi-partite quantum system via sequential…

Quantum Physics · Physics 2017-09-25 Sarah Croke , Stephen M. Barnett , Graeme Weir

We address the question of finding the most effective convex decompositions into boundary elements (so-called boundariness) for sets of quantum states, observables and channels. First we show that in general convex sets the boundariness…

Quantum Physics · Physics 2015-09-28 Zbigniew Puchała , Anna Jencova , Michal Sedlak , Mario Ziman

Maximizing the precision in estimating parameters in a quantum system subject to instrumentation constraints is cast as a convex optimization problem. We account for prior knowledge about the parameter range by developing a worst-case and…

Quantum Physics · Physics 2008-04-01 Robert L. Kosut