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In silico de novo design can drastically cut the costs and time of drug development. In particular, a key advantage of bottom-up physics-based approaches is their independence from training datasets, unlike generative models. However, they…

Quantum Physics · Physics 2025-12-01 Lars Meuser , Alexandros Patsilinakos , Pietro Faccioli

Specification theories as a tool in model-driven development processes of component-based software systems have recently attracted a considerable attention. Current specification theories are however qualitative in nature, and therefore…

Logic in Computer Science · Computer Science 2012-10-23 Sebastian S. Bauer , Uli Fahrenberg , Line Juhl , Kim G. Larsen , Axel Legay , Claus Thrane

Direct design of complex functional materials would revolutionize technologies ranging from printable organs to novel clean energy devices. However, even incremental steps towards designing functional materials have proven challenging. If…

Soft Condensed Matter · Physics 2024-06-26 Ella M. King , Chrisy Xiyu Du , Qian-Ze Zhu , Samuel S. Schoenholz , Michael P. Brenner

We present the concept of a feedback-based topological acoustic metamaterial as a tool for realizing autonomous and active guiding of sound beams along arbitrary curved paths in free two-dimensional space. The metamaterial building blocks…

Applied Physics · Physics 2021-01-01 Lea Sirota , Daniel Sabsovich , Yoav Lahini , Roni Ilan , Yair Shokef

Implementing the time evolution under a desired target Hamiltonian is critical for various applications in quantum science. Due to the exponential increase in the number of parameters with system size and experimental imperfections, this…

Quantum Physics · Physics 2025-12-11 Pascal Baßler , Markus Heinrich , Martin Kliesch

Simulating plasma physics on quantum computers is difficult because most problems of interest are nonlinear, but quantum computers are not naturally suitable for nonlinear operations. In weakly nonlinear regimes, plasma problems can be…

Quantum Hamiltonian Computing is a recent approach that uses quantum systems, in particular a single molecule, to perform computational tasks. Within this approach, we present explicit methods to construct logic gates using two different…

Quantum Physics · Physics 2019-06-18 Omid Faizy Namarvar , Olivier Giraud , Bertrand Georgeot , Christian Joachim

We report on our recent efforts to perform realistic simulations of large quantum devices in the time domain. In contrast to d.c. transport where the calculations are explicitly performed at the Fermi level, the presence of time-dependent…

Mesoscale and Nanoscale Physics · Physics 2017-10-26 Joseph Weston , Xavier Waintal

More computational resources (i.e., more physical qubits and qubit connections) on a superconducting quantum processor not only improve the performance but also result in more complex chip architecture with lower yield rate. Optimizing both…

Quantum Physics · Physics 2019-12-02 Gushu Li , Yufei Ding , Yuan Xie

This technical note describes the FluidFlower concept, a new laboratory infrastructure for geological carbon storage research. The highly controlled and adjustable system produces a strikingly visual physical ground truth of studied…

In computer simulations, quantum delocalization of atomic nuclei can be modeled making use of the Path Integral (PI) formulation of quantum statistical mechanics. This approach, however, comes with a large computational cost. By restricting…

Statistical Mechanics · Physics 2015-04-13 Karsten Kreis , Mark E. Tuckerman , Davide Donadio , Kurt Kremer , Raffaello Potestio

Metal-organic frameworks (MOFs) are porous materials composed of metal ions and organic linkers. Due to their chemical diversity, MOFs can support a broad range of applications in chemical separations. However, the vast amount of structural…

We present PyAtoms, an interactive open-source software that rapidly simulates atomic-scale scanning tunneling microscopy (STM) and other scanning probe microscopy (SPM) images of two-dimensional (2D) layered materials, moir\'{e} systems,…

In this paper, we review some recent work on amorphous materials using current "first principles" electronic structure/molecular dynamics techniques. The main theme of the paper is to emphasize new directions in the use of such ab initio…

Disordered Systems and Neural Networks · Physics 2007-05-23 D. A. Drabold , P. Biswas , D. Tafen , R. Atta-Fynn

Developing devices that can reliably and accurately demonstrate the principles of superposition and entanglement is an on-going challenge for the quantum computing community. Modeling and simulation offer attractive means of testing early…

The tremendous challenge of comparing our theoretical models with the gravitational-wave observations in the new era of multimessenger astronomy requires accurate and fast numerical simulations of complicated physical systems described by…

Quantum computing has recently been emerging in theoretical chemistry as a realistic avenue meant to offer computational speedup to challenging eigenproblems in the context of strongly-correlated molecular systems or extended materials.…

Quantum Physics · Physics 2026-03-05 Joachim Knapik , Bruno Senjean , Benjamin Lasorne , Yohann Scribano

Simulating trajectories of dynamical systems is a fundamental problem in a wide range of fields such as molecular dynamics, biochemistry, and pedestrian dynamics. Machine learning has become an invaluable tool for scaling physics-based…

Machine Learning · Computer Science 2026-05-28 Kiet Bennema ten Brinke , Koen Minartz , Vlado Menkovski

We develop an open-source, end-to-end software (named QHDOPT), which can solve nonlinear optimization problems using the quantum Hamiltonian descent (QHD) algorithm. QHDOPT offers an accessible interface and automatically maps tasks to…

Quantum Physics · Physics 2024-09-06 Samuel Kushnir , Jiaqi Leng , Yuxiang Peng , Lei Fan , Xiaodi Wu