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Digital Microfluidic Biochips consist of Two Dimensional microarrays that are integrated with different healthcare related cyberphysical systems and expected to be used extensively in near future. Thus, faster and error-free synthesis…

Emerging Technologies · Computer Science 2018-04-10 Sarit Chakraborty , Susanta Chakraborty

Microfluidic technology has emerged as a powerful tool for studying complex biological processes with enhanced precision and control. A microfluidic chip was designed to emulate human-like microvascular networks with precise control over…

Biological Physics · Physics 2025-02-18 Shobhit Das , Shilpi Pandey , Oliver Hayden

Large-scale microfluidic microsystems with complex three-dimensional (3D) configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative…

Applied Physics · Physics 2020-01-13 Zijie Lin , Jian Xu , Yunpeng Song , Xiaolong Li , Peng Wang , Wei Chu , Zhenhua Wang , Ya Cheng

Cryo-electron microscopy (cryo-EM) is a powerful technique in structural biology and drug discovery, enabling the study of biomolecules at high resolution. Significant advancements by structural biologists using cryo-EM have led to the…

Biomolecules · Quantitative Biology 2024-12-05 Yi Zhou , Yilai Li , Jing Yuan , Quanquan Gu

Ultrasound-vaporizable microdroplets can be exploited for targeted drug delivery. However, it requires customized microfluidic techniques able to produce monodisperse, capillary-sized and biocompatible multiple emulsions. Recent development…

Soft Condensed Matter · Physics 2019-12-17 E. Teston , V. Hingot , V. Faugeras , C. Errico , M. Bezagu , M. Tanter , O. Couture

The tendency for flows in microfluidic systems to behave linearly poses a challenge for designing integrated flow control schemes to carry out complex fluid processing tasks. This hindrance has led to the use of numerous external control…

Fluid Dynamics · Physics 2020-06-18 Daniel J. Case , Jean-Regis Angilella , Adilson E. Motter

The efficient and voidless filling of microcavities is of great importance for Lab-on-a-Chip applications. However, predicting whether microcavities will be filled or not under different circumstances is still difficult due to the local…

Fluid Dynamics · Physics 2025-04-02 Luise Nagel , Anja Lippert , Ronny Leonhardt , Tobias Tolle , Huijie Zhang , Tomislav Maric

We demonstrate novel instrumentation for spontaneous Raman spectroscopy in biofluids, enabling development of a portable, automated, reliable diagnostics technique requiring minimal operator expertise to quantify disease markers. Label-free…

Biological Physics · Physics 2021-05-27 Emily E. Storey , Duxuan Wu , Amr S. Helmy

Photoelectron emission microscopy PEEM is a powerful tool to spectroscopically image dynamic surface processes at the nanoscale but is traditionally limited to ultra high or moderate vacuum conditions. Here, we develop a novel grapheme…

High-density microfluidics is becoming an important experimental platform for studying complex biological systems such as synthetic gene regulatory networks, molecular biocomputating of engineered cells, distributing rapid point-of-care…

Biological Physics · Physics 2021-07-21 Sankar Raju Narayanasamy , Ramakrishna Vasireddi , Hoi-Ying Holman

We have developed a microfluidic tool to measure the diffusion coefficient $D$ of solutes in an aqueous solution, by following the temporal relaxation of an initially steep concentration gradient in a microchannel. Our chip exploits…

Soft Condensed Matter · Physics 2022-08-23 Hoang-Thanh Nguyen , Anne Bouchaudy , Jean-Baptiste Salmon

Microfluidic devices are gaining attention for their small size and ability to handle tiny fluid volumes. Mixing fluids efficiently at this scale, known as micromixing, is crucial. This article builds upon previous research by introducing a…

The efficient mixing of fluid samples in miniaturized total analysis systems is essential for numerous applications including biological screening assays, chemical extraction, polymerization, cell analysis, and protein folding. Miniaturized…

Fluid Dynamics · Physics 2022-10-25 S. A. Iqrar , J. Park , M. Afzal , H. J. Sung

Diffusion- and flow-based models have emerged as state-of-the-art generative modeling approaches, but they require many sampling steps. Consistency models can distill these models into efficient one-step generators; however, unlike flow-…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 Amirmojtaba Sabour , Sanja Fidler , Karsten Kreis

Motivated by recent experimental advances (Stroock et al. 2002) in microfluidic mixers, we study the passive mixing and flow properties of a patterned microchannel by means of computational fluid dynamics (CFD). Such geometries overcome the…

Soft Condensed Matter · Physics 2007-05-23 J. P. Bennett , C. H. Wiggins

Inertial fluid flow deformation around pillars in a microchannel is a new method for controlling fluid flow. Sequences of pillars have been shown to produce a rich phase space with a wide variety of flow transformations. Previous work has…

With the aim of efficiently simulating three-dimensional multiphase turbulent flows with a phase-field method, we propose a new discretization scheme for the biharmonic term (the 4th-order derivative term) of the Cahn-Hilliard equation.…

Fluid Dynamics · Physics 2022-05-24 Hao-Ran Liu , Chong Shen Ng , Kai Leong Chong , Detlef Lohse , Roberto Verzicco

Ferrohydrodynamic microfluidics relies on magnetic field gradients to manipulate diamagnetic particles in ferrofluid-filled microenvironments. It has emerged as a promising tool for label-free manipulation of bioparticles, including their…

Systems and Control · Electrical Eng. & Systems 2025-11-03 Yuhao Zhang , Yong Teng , Kenan Song , Xianqiao Wang , Xianyan Chen , Yuhua Liu , Yiping Zhao , He Li , Leidong Mao , Yang Liu

Microfluidic devices are increasingly used in biological and chemical experiments due to their cost-effectiveness for rheological estimation in fluids. However, these devices often face challenges in terms of accuracy, size, and cost. This…

Droplet-based microfluidics systems have become widely used in recent years thanks to their advantages, varying from the possibility of handling small fluid volumes to directly synthesizing and encapsulating various living forms for…