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Background: Phase I dose-finding trials increasingly encounter delayed-onset toxicities, especially with immunotherapies and targeted agents. The time-to-event continual reassessment method (TITE-CRM) handles incomplete follow-up using…

Methodology · Statistics 2026-02-24 Robert Amevor , Emmanuel Kubuafor , Dennis Baidoo

With the advancement in drug development, multiple treatments are available for a single disease. Patients can often benefit from taking multiple treatments simultaneously. For example, patients in Clinical Practice Research Datalink (CPRD)…

Applications · Statistics 2018-04-17 Muxuan Liang , Ye Ting , Haoda Fu

When the experimental objective is expressed by a set of estimable functions, and any eigenvalue-based optimality criterion is selected, we prove the equivalence of the recently introduced weighted optimality and the 'standard' optimality…

Statistics Theory · Mathematics 2016-10-21 Samuel Rosa

The widespread use of the internet has led to an overwhelming amount of data, which has resulted in the problem of information overload. Recommender systems have emerged as a solution to this problem by providing personalized…

Information Retrieval · Computer Science 2024-08-15 Hui Fang , Xu Feng , Lu Qin , Zhu Sun

The hyperparameters of recommender systems for top-n predictions are typically optimized to enhance the predictive performance of algorithms. Thereby, the optimization algorithm, e.g., grid search or random search, searches for the best…

Information Retrieval · Computer Science 2024-01-17 Lukas Wegmeth , Tobias Vente , Lennart Purucker

Radiotherapy (RT) planning is complex, subjective, and time-intensive. Advances with artificial intelligence (AI) promise to improve its precision and efficiency, but progress is often limited by the scarcity of large, standardized…

Global expression analyses using microarray technologies are becoming more common in genomic research, therefore, new statistical challenges associated with combining information from multiple studies must be addressed. In this paper we…

Applications · Statistics 2013-01-29 Jia Li , George C. Tseng

Online matching has been a mainstay in domains such as Internet advertising and organ allocation, but practical algorithms often lack strong theoretical guarantees. We take an important step toward addressing this by developing new online…

Machine Learning · Computer Science 2026-02-09 Itai Zilberstein , Ioannis Anagnostides , Zachary W. Sollie , Arman Kilic , Tuomas Sandholm

Weighted low rank approximation is a fundamental problem in numerical linear algebra, and it has many applications in machine learning. Given a matrix $M \in \mathbb{R}^{n \times n}$, a non-negative weight matrix $W \in \mathbb{R}_{\geq…

Machine Learning · Computer Science 2025-02-18 Zhao Song , Mingquan Ye , Junze Yin , Lichen Zhang

As the growing interest of web recommendation systems those are applied to deliver customized data for their users, we started working on this system. Generally the recommendation systems are divided into two major categories such as…

Information Retrieval · Computer Science 2013-12-02 Ujwala Wanaskar , Sheetal Vij , Debajyoti Mukhopadhyay

The large-scale multiple testing inherent to high throughput biological data necessitates very high statistical stringency and thus true effects in data are difficult to detect unless they have high effect sizes. One promising approach for…

Methodology · Statistics 2022-03-14 Mohamad Hasan , Paul Schliekelman

Breast cancer is a serious disease that inflicts millions of people each year, and the number of cases is increasing. Early detection is the best way to reduce the impact of the disease. Researchers have developed many techniques to detect…

Artificial Intelligence · Computer Science 2023-11-23 Mosab S. M. Farea , zhe chen

Knee-Joint Osteoarthritis (KOA) is a prevalent cause of global disability and is inherently complex to diagnose due to its subtle radiographic markers and individualized progression. One promising classification avenue involves applying…

Image and Video Processing · Electrical Eng. & Systems 2023-11-13 Fabi Prezja , Leevi Annala , Sampsa Kiiskinen , Suvi Lahtinen , Timo Ojala

The uncontrolled and unstructured growth of brain cells is known as brain tumor, which has one of the highest mortality rates among diseases from all types of cancers. Due to limited diagnostic and treatment capabilities, they pose…

Machine Learning · Computer Science 2024-04-02 PoTsang B. Huang , Muhammad Rizwan , Mehboob Ali

In a treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for organs. Recent discoveries indicate that…

Medical Physics · Physics 2012-10-29 Masoud Zarepisheh , Andres F. Uribe-Sanchez , Nan Li , Xun Jia , Steve B. Jiang

The inverse probability weighting (IPW) is broadly utilized to address missing data problems including causal inference but may suffer from large variances and biases due to propensity score model misspecification. To solve these problems,…

Methodology · Statistics 2020-08-05 Hiroto Katsumata

With the increasing penetration of machine learning applications in critical decision-making areas, calls for algorithmic fairness are more prominent. Although there have been various modalities to improve algorithmic fairness through…

Machine Learning · Computer Science 2024-05-21 Zhihao Hu , Yiran Xu , Mengnan Du , Jindong Gu , Xinmei Tian , Fengxiang He

The paper presents a solution for the problem of choosing a method for analytical determining of weight factors for a genetic algorithm additive fitness function. This algorithm is the basis for an evolutionary process, which forms a stable…

Neural and Evolutionary Computing · Computer Science 2021-03-30 V. K. Ivanov , D. S. Dumina , N. A. Semenov

One primary goal of precision medicine is to estimate the individualized treatment rules (ITRs) that optimize patients' health outcomes based on individual characteristics. Health studies with multiple treatments are commonly seen in…

Methodology · Statistics 2025-05-07 Xuqiao Li , Qiuyan Zhou , Ying Wu , Ying Yan

The coexistence of different Radio Access Technologies (RATs) in the same area has enabled the researchers to get profit from the available networks by the selection of the best RAT at each moment to satisfy the user requirements. The…

Networking and Internet Architecture · Computer Science 2022-01-31 Bendaoud Fayssal , Abdennebi Marwen , Didi Fedoua