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In this work, we introduce a flow based machine learning approach, called reaction coordinate (RC) flow, for discovery of low-dimensional kinetic models of molecular systems. The RC flow utilizes a normalizing flow to design the coordinate…

Machine Learning · Computer Science 2023-09-13 Hao Wu , Frank Noé

Many real-world control systems, such as the smart grid and human sensorimotor control systems, have decentralized components that react quickly using local information and centralized components that react slowly using a more global view.…

Optimization and Control · Mathematics 2017-11-15 Gautam Goel , Niangjun Chen , Adam Wierman

Stochastic computing (SC) is an emerging computing technique that promises high density, low power, and error tolerant solutions. In SC, values are encoded as unary bitstreams and SC arithmetic circuits operate on one or more bitstreams. In…

Signal Processing · Electrical Eng. & Systems 2018-03-14 Vincent T. Lee , Armin Alaghi , Luis Ceze

Monte Carlo estimation in plays a crucial role in stochastic reaction networks. However, reducing the statistical uncertainty of the corresponding estimators requires sampling a large number of trajectories. We propose control variates…

Methodology · Statistics 2021-10-19 Michael Backenköhler , Luca Bortolussi , Verena Wolf

Reservoir computing (RC) is a state-of-the-art machine learning method that makes use of the power of dynamical systems (the reservoir) for real-time inference. When using biological complex systems as reservoir substrates, it serves as a…

Adaptation and Self-Organizing Systems · Physics 2026-03-03 Mario U. Gaimann , Miriam Klopotek

Successful detection of weak signals is a universal challenge for numerous technical and biological systems and crucially limits signal transduction and transmission. Stochastic resonance (SR) has been identified to have the potential to…

Information Theory · Computer Science 2015-04-21 Patrick Krauss , Claus Metzner , Konstantin Tziridis , Holger Schulze

Model predictive controllers use dynamics models to solve constrained optimal control problems. However, computational requirements for real-time control have limited their use to systems with low-dimensional models. Nevertheless,…

Systems and Control · Electrical Eng. & Systems 2024-10-30 Joseph Lorenzetti , Andrew McClellan , Charbel Farhat , Marco Pavone

Understanding brain function, constructing computational models and engineering neural prosthetics require assessing two problems, namely encoding and decoding, but their relation remains controversial. For decades, the encoding problem has…

Neurons and Cognition · Quantitative Biology 2017-01-16 Hugo Gabriel Eyherabide

This paper is concerned with collective variables, or reaction coordinates, that map a discrete-in-time Markov process $X_n$ in $\mathbb{R}^d$ to a (much) smaller dimension $k \ll d$. We define the effective dynamics under a given…

Optimization and Control · Mathematics 2025-03-12 Wei Zhang , Christof Schütte

It is a longstanding unsolved problem to characterize the optimal feedback controls for general linear quadratic optimal control problem of stochastic evolution equation with random coefficients. A solution to this problem is given in [21]…

Optimization and Control · Mathematics 2022-02-22 Qi Lü , Tianxiao Wang

We introduce a new methodology 'charcoal' for estimating the location of sparse changes in high-dimensional linear regression coefficients, without assuming that those coefficients are individually sparse. The procedure works by…

Statistics Theory · Mathematics 2023-05-23 Fengnan Gao , Tengyao Wang

This paper proposes an Adaptive Stochastic Model Predictive Control (MPC) strategy for stable linear time-invariant systems in the presence of bounded disturbances. We consider multi-input, multi-output systems that can be expressed by a…

Systems and Control · Electrical Eng. & Systems 2019-12-11 Monimoy Bujarbaruah , Charlott Vallon

Many robotics tasks, such as path planning or trajectory optimization, are formulated as optimal control problems (OCPs). The key to obtaining high performance lies in the design of the OCP's objective function. In practice, the objective…

Systems and Control · Electrical Eng. & Systems 2025-04-02 Trevor Barron , Xiaojing Zhang

Reservoir computing (RC) is known as a powerful machine learning approach for learning complex dynamics from limited data. Here, we use RC to predict highly stochastic dynamics of cell shapes. We find that RC is able to predict the steady…

Biological Physics · Physics 2024-09-17 Hoony Kang , Keshav Srinivasan , Wolfgang Losert

We address the design and synthesis of optimal control strategies for high-dimensional stochastic dynamical systems. Such systems may be deterministic nonlinear systems evolving from random initial states, or systems driven by random…

Numerical Analysis · Mathematics 2020-08-26 Panos Lambrianides , Qi Gong , Daniele Venturi

Exact inference in complex probabilistic models often incurs prohibitive computational costs. This challenge is particularly acute for autonomous agents in dynamic environments that require frequent, real-time belief updates. Existing…

Artificial Intelligence · Computer Science 2026-02-10 Simon Kohaut , Benedict Flade , Julian Eggert , Kristian Kersting , Devendra Singh Dhami

We address an optimal control problem for linear stochastic systems with unknown noise distributions and joint chance constraints using conformal prediction. Our approach involves designing a feedback controller to maintain an error system…

Systems and Control · Electrical Eng. & Systems 2024-12-10 Eleftherios E. Vlahakis , Lars Lindemann , Pantelis Sopasakis , Dimos V. Dimarogonas

Understanding the dynamics of complex systems is a central task in many different areas ranging from biology via epidemics to economics and engineering. Unexpected behaviour of dynamic systems or even system failure is sometimes difficult…

Optimization and Control · Mathematics 2022-03-25 Dominik Kahl , Andreas Weber , Maik Kschischo

Chaotic dynamical systems pose a fundamental challenge for Reinforcement Learning (RL): exponential sensitivity to initial conditions induces high-variance bootstrap targets and poorly conditioned gradient updates. Chaotic dynamics arise…

Machine Learning · Computer Science 2026-05-29 James Rudd-Jones , Mirco Musolesi , María Pérez-Ortiz

Information processing abilities of active matter are studied in the reservoir computing (RC) paradigm to infer the future state of a chaotic signal. We uncover an exceptional regime of agent dynamics that has been overlooked previously. It…

Adaptation and Self-Organizing Systems · Physics 2026-01-26 Mario U. Gaimann , Miriam Klopotek