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Protein folding is the intricate process by which a linear sequence of amino acids self-assembles into a unique three-dimensional structure. Protein folding kinetics is the study of pathways and time-dependent mechanisms a protein undergoes…

Machine Learning · Computer Science 2023-09-19 Vijay Arvind. R , Haribharathi Sivakumar , Brindha. R

We propose a method for low-rank semidefinite programming in application to the semidefinite relaxation of unconstrained binary quadratic problems. The method improves an existing solution of the semidefinite programming relaxation to…

Optimization and Control · Mathematics 2021-12-07 Roman Pogodin , Mikhail Krechetov , Yury Maximov

This work addresses the uniform parallel machine scheduling problem within an optimistic bilevel optimization framework. The leader seeks to minimize the weighted number of tardy jobs, while the follower aims to minimize the total…

Optimization and Control · Mathematics 2026-05-20 Quentin Schau , Federico Della Croce , Olivier Ploton , Vincent t'Kindt

Optimal control of obstacle problems arises in a wide range of applications and is computationally challenging due to its nonsmoothness, nonlinearity, and bilevel structure. Classical numerical approaches rely on mesh-based discretization…

Optimization and Control · Mathematics 2026-01-08 Yongcun Song , Shangzhi Zeng , Jin Zhang , Lvgang Zhang

Bilevel programs (BPs) find a wide range of applications in fields such as energy, transportation, and machine learning. As compared to BPs with continuous (linear/convex) optimization problems in both levels, the BPs with discrete decision…

Optimization and Control · Mathematics 2024-07-25 Bo Zhou , Ruiwei Jiang , Siqian Shen

The problem of community detection with two equal-sized communities is closely related to the minimum graph bisection problem over certain random graph models. In the stochastic block model distribution over networks with community…

Optimization and Control · Mathematics 2022-05-13 Alberto Del Pia , Aida Khajavirad , Dmitriy Kunisky

Linear regression is a popular machine learning approach to learn and predict real valued outputs or dependent variables from independent variables or features. In many real world problems, its beneficial to perform sparse linear regression…

Machine Learning · Computer Science 2021-06-07 Surya Sai Teja Desu , P. K. Srijith , M. V. Panduranga Rao , Naveen Sivadasan

Solving systems of Boolean equations is a fundamental task in symbolic computation and algebraic cryptanalysis, with wide-ranging applications in cryptography, coding theory, and formal verification. Among existing approaches, the Boolean…

Cryptography and Security · Computer Science 2026-04-21 Minzhong Luo , Yudong Sun , Yin Long

The construction of machine learning models involves many bi-level multi-objective optimization problems (BL-MOPs), where upper level (UL) candidate solutions must be evaluated via training weights of a model in the lower level (LL). Due to…

Neural and Evolutionary Computing · Computer Science 2023-02-07 Chao Wang , Licheng Jiao , Jiaxuan Zhao , Lingling Li , Xu Liu , Fang Liu , Shuyuan Yang

Probabilistic shaping is a pragmatic approach to improve the performance of coherent optical fiber communication systems. In the nonlinear regime, the advantages offered by probabilistic shaping might increase thanks to the opportunity to…

Information Theory · Computer Science 2024-01-19 Stella Civelli , Enrico Forestieri , Marco Secondini

In a regression setting we propose algorithms that reduce the dimensionality of the features while simultaneously maximizing a statistical measure of dependence known as distance correlation between the low-dimensional features and a…

Machine Learning · Computer Science 2017-02-20 Praneeth Vepakomma , Ahmed Elgammal

Fine-tuning on task-specific data to boost downstream performance is a crucial step for leveraging Large Language Models (LLMs). However, previous studies have demonstrated that fine-tuning the models on several adversarial samples or even…

Machine Learning · Computer Science 2024-10-14 Han Shen , Pin-Yu Chen , Payel Das , Tianyi Chen

The ability to accelerate the design of biological sequences can have a substantial impact on the progress of the medical field. The problem can be framed as a global optimization problem where the objective is an expensive black-box…

Machine Learning · Computer Science 2022-09-15 Leo Feng , Padideh Nouri , Aneri Muni , Yoshua Bengio , Pierre-Luc Bacon

Sequences with a low correlation have very important applications in communications, cryptography, and compressed sensing. In the literature, many efforts have been made to construct good sequences with various lengths where binary…

Information Theory · Computer Science 2022-10-25 Lingfei Jin , Liming Ma , Chaoping Xing

We present a new method for analyzing the running time of parallel evolutionary algorithms with spatially structured populations. Based on the fitness-level method, it yields upper bounds on the expected parallel running time. This allows…

Neural and Evolutionary Computing · Computer Science 2012-06-18 Jörg Lässig , Dirk Sudholt

Stochastic binary hidden units in a multi-layer perceptron (MLP) network give at least three potential benefits when compared to deterministic MLP networks. (1) They allow to learn one-to-many type of mappings. (2) They can be used in…

Machine Learning · Statistics 2015-04-10 Tapani Raiko , Mathias Berglund , Guillaume Alain , Laurent Dinh

In this paper, we study smooth stochastic multi-level composition optimization problems, where the objective function is a nested composition of $T$ functions. We assume access to noisy evaluations of the functions and their gradients,…

Optimization and Control · Mathematics 2022-02-15 Krishnakumar Balasubramanian , Saeed Ghadimi , Anthony Nguyen

We introduce a unified framework for the study of multilevel mixed integer linear optimization problems and multistage stochastic mixed integer linear optimization problems with recourse. The framework highlights the common mathematical…

Optimization and Control · Mathematics 2021-04-20 Suresh Bolusani , Stefano Coniglio , Ted. K. Ralphs , Sahar Tahernejad

We study a stochastic control problem where the underlying process follows a spectrally negative L\'{e}vy process. A controller can continuously increase the process but only decrease it at independent Poisson arrival times. We show the…

Optimization and Control · Mathematics 2025-05-30 Kazutoshi Yamazaki , Qingyuan Zhang

This paper addresses the problem of sequential submodular maximization: selecting and ranking items in a sequence to optimize some composite submodular function. In contrast to most of the previous works, which assume access to the utility…

Machine Learning · Computer Science 2024-09-10 Jing Yuan , Shaojie Tang