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Test-time guidance is a widely used mechanism for steering pretrained diffusion models toward outcomes specified by a reward function. Existing approaches, however, focus on maximizing reward rather than sampling from the true Bayesian…

Machine Learning · Computer Science 2026-02-27 Daniel Geyfman , Felix Draxler , Jan Groeneveld , Hyunsoo Lee , Theofanis Karaletsos , Stephan Mandt

The bootstrap provides a simple and powerful means of assessing the quality of estimators. However, in settings involving large datasets---which are increasingly prevalent---the computation of bootstrap-based quantities can be prohibitively…

Methodology · Statistics 2012-06-29 Ariel Kleiner , Ameet Talwalkar , Purnamrita Sarkar , Michael I. Jordan

We investigate signatures of broken time reversal symmetry in stochastic trajectory data, employing the previously introduced three point correlation called mean back relaxation. We specifically investigate data from a simple driven model,…

Soft Condensed Matter · Physics 2026-03-18 Gabriel Knotz , Till M. Muenker , Timo Betz , Matthias Krüger

Bootstrap is a principled and powerful frequentist statistical tool for uncertainty quantification. Unfortunately, standard bootstrap methods are computationally intensive due to the need of drawing a large i.i.d. bootstrap sample to…

Machine Learning · Computer Science 2022-09-02 Mao Ye , Qiang Liu

We derived a number of numerical methods to treat biomolecular systems with multiple time scales. Based on the splitting of the operators associated with the slow-varying and fast-varying forces, new multiple time-stepping (MTS) methods are…

Numerical Analysis · Mathematics 2015-01-15 Chao Liang , Xiaolan Yuan , Xiantao Li

The paper studies a problem of constructing simultaneous likelihood-based confidence sets. We consider a simultaneous multiplier bootstrap procedure for estimating the quantiles of the joint distribution of the likelihood ratio statistics,…

Statistics Theory · Mathematics 2015-06-19 Mayya Zhilova

Computer simulations of many-body quantum dynamics of indistinguishable particles is a challenging task for computational physics. In this paper we demonstrate that the method of coupled coherent states (CCS) developed previously for…

Quantum Physics · Physics 2019-07-17 James A. Green , Dmitrii V. Shalashilin

Entropy estimation plays a crucial role in various fields, such as information theory, statistical data science, and machine learning. However, traditional entropy estimation methods often struggle with complex data distributions.…

Methodology · Statistics 2025-05-16 Luca Scrucca

In the class of immersed boundary (IB) methods, the choice of the delta function plays a crucial role in transferring information between fluid and solid domains. Most prior work has used isotropic kernels that do not preserve the…

Numerical Analysis · Mathematics 2024-12-23 Lianxia Li , Cole Gruninger , Jae H. Lee , Boyce E. Griffith

Fitting sparse models to high-dimensional time series is an important area of statistical inference. In this paper we consider sparse vector autoregressive models and develop appropriate bootstrap methods to infer properties of such…

Methodology · Statistics 2019-09-25 J. Krampe , J-P. Kreiss , E. Paparoditis

Although atomistic simulations of proteins and other biological systems are approaching microsecond timescales, the quality of trajectories has remained difficult to assess. Such assessment is critical not only for establishing the…

Quantitative Methods · Quantitative Biology 2007-05-23 Edward Lyman , Daniel M. Zuckerman

Extending the famous Model B for the time evolution of a liquid mixture, we derive an approximate expression for the mobility matrix that couples the different mixture components. This approach is based on a single component fluid with…

Statistical Mechanics · Physics 2023-06-21 Maryam Akaberian , Filipe C Thewes , Peter Sollich , Matthias Krüger

The bootstrap, introduced by Efron (1982), has become a very popular method for estimating variances and constructing confidence intervals. A key insight is that one can approximate the properties of estimators by using the empirical…

Methodology · Statistics 2019-01-29 Guido Imbens , Konrad Menzel

The exactly solvable quantum many-particle model with harmonic one- and two-particle interaction terms is extended to include time-dependency. We show that when the external trap potential and finite-range interparticle interaction have a…

The network inference problem arises in biological research when one needs to quantitatively choose the best protein-interaction model for explaining a phenotype. The diverse nature of the data and nonlinear dynamics pose significant…

Molecular Networks · Quantitative Biology 2025-12-22 Guy Karlebach

Safety evaluation of self-driving technologies has been extensively studied. One recent approach uses Monte Carlo based evaluation to estimate the occurrence probabilities of safety-critical events as safety measures. These Monte Carlo…

Methodology · Statistics 2019-07-19 Zhiyuan Huang , Mansur Arief , Henry Lam , Ding Zhao

Multivariate time series present many challenges, especially when they are high dimensional. The paper's focus is twofold. First, we address the subject of consistently estimating the autocovariance sequence; this is a sequence of matrices…

Statistics Theory · Mathematics 2015-06-03 Carsten Jentsch , Dimitris N. Politis

Understanding the binding dynamics of liquid molecules is of fundamental importance in physical and life sciences. However, nanoscale fast dynamics pose great challenges for experimental characterization. Conventionally, the binding…

Chemical Physics · Physics 2024-10-28 Shiyi Qin , Zhi Yang , Huimin Liu , Xiaoli Wang , Shangguo Hou , Kai Huang

An inference procedure is proposed to provide consistent estimators of parameters in a modal regression model with a covariate prone to measurement error. A score-based diagnostic tool exploiting parametric bootstrap is developed to assess…

Methodology · Statistics 2024-07-02 Qingyang Liu , Xianzheng Huang

We consider the problem of finding confidence intervals for the risk of forecasting the future of a stationary, ergodic stochastic process, using a model estimated from the past of the process. We show that a bootstrap procedure provides…

Statistics Theory · Mathematics 2017-12-01 Robert Lunde , Cosma Rohilla Shalizi