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Regularized Auto-Encoders (RAEs) form a rich class of neural generative models. They effectively model the joint-distribution between the data and the latent space using an Encoder-Decoder combination, with regularization imposed in terms…

Machine Learning · Computer Science 2020-09-22 Arnab Kumar Mondal , Himanshu Asnani , Parag Singla , Prathosh AP

The choice of an appropriate bottleneck dimension and the application of effective regularization are both essential for Autoencoders to learn meaningful representations from unlabeled data. In this paper, we introduce a new class of…

Machine Learning · Computer Science 2025-03-26 Jad Mounayer , Sebastian Rodriguez , Chady Ghnatios , Charbel Farhat , Francisco Chinesta

Deterministic Rank Reduction Autoencoders (RRAEs) enforce by construction a regularization on the latent space by applying a truncated SVD. While this regularization makes Autoencoders more powerful, using them for generative purposes is…

Machine Learning · Computer Science 2025-10-15 Jad Mounayer , Alicia Tierz , Jerome Tomezyk , Chady Ghnatios , Francisco Chinesta

Unsupervised representation learning via generative modeling is a staple to many computer vision applications in the absence of labeled data. Variational Autoencoders (VAEs) are powerful generative models that learn representations useful…

Machine Learning · Computer Science 2020-03-24 Riddhish Bhalodia , Iain Lee , Shireen Elhabian

As one of the most popular generative models, Variational Autoencoder (VAE) approximates the posterior of latent variables based on amortized variational inference. However, when the decoder network is sufficiently expressive, VAE may lead…

Machine Learning · Computer Science 2021-10-26 Dazhong Shen , Chuan Qin , Chao Wang , Hengshu Zhu , Enhong Chen , Hui Xiong

Recently, a number of works have studied clustering strategies that combine classical clustering algorithms and deep learning methods. These approaches follow either a sequential way, where a deep representation is learned using a deep…

Machine Learning · Computer Science 2019-06-13 Severine Affeldt , Lazhar Labiod , Mohamed Nadif

We study a variant of the variational autoencoder model (VAE) with a Gaussian mixture as a prior distribution, with the goal of performing unsupervised clustering through deep generative models. We observe that the known problem of…

Variational Autoencoders (VAEs) provide a theoretically-backed and popular framework for deep generative models. However, learning a VAE from data poses still unanswered theoretical questions and considerable practical challenges. In this…

Machine Learning · Computer Science 2020-06-01 Partha Ghosh , Mehdi S. M. Sajjadi , Antonio Vergari , Michael Black , Bernhard Schölkopf

A new algorithmic framework is proposed for learning autoencoders of data distributions. We minimize the discrepancy between the model and target distributions, with a \emph{relational regularization} on the learnable latent prior. This…

Machine Learning · Computer Science 2020-06-29 Hongteng Xu , Dixin Luo , Ricardo Henao , Svati Shah , Lawrence Carin

Variational Autoencoders (VAEs) have experienced recent success as data-generating models by using simple architectures that do not require significant fine-tuning of hyperparameters. However, VAEs are known to suffer from…

Machine Learning · Statistics 2020-07-22 Wei Cheng , Gregory Darnell , Sohini Ramachandran , Lorin Crawford

Latent variable models such as the Variational Auto-Encoder (VAE) have become a go-to tool for analyzing biological data, especially in the field of single-cell genomics. One remaining challenge is the interpretability of latent variables…

Genomics · Quantitative Biology 2023-02-20 Romain Lopez , Nataša Tagasovska , Stephen Ra , Kyunghyn Cho , Jonathan K. Pritchard , Aviv Regev

As a powerful approach for exploratory data analysis, unsupervised clustering is a fundamental task in computer vision and pattern recognition. Many clustering algorithms have been developed, but most of them perform unsatisfactorily on the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-25 Pengfei Ge , Chuan-Xian Ren , Jiashi Feng , Shuicheng Yan

We propose a novel method, scTree, for single-cell Tree Variational Autoencoders, extending a hierarchical clustering approach to single-cell RNA sequencing data. scTree corrects for batch effects while simultaneously learning a…

Machine Learning · Computer Science 2024-07-11 Moritz Vandenhirtz , Florian Barkmann , Laura Manduchi , Julia E. Vogt , Valentina Boeva

Approximating distributions over complicated manifolds, such as natural images, are conceptually attractive. The deep latent variable model, trained using variational autoencoders and generative adversarial networks, is now a key technique…

Computer Vision and Pattern Recognition · Computer Science 2019-10-08 Wenju Xu , Shawn Keshmiri , Guanghui Wang

In this paper we propose Structuring AutoEncoders (SAE). SAEs are neural networks which learn a low dimensional representation of data which are additionally enriched with a desired structure in this low dimensional space. While traditional…

Machine Learning · Computer Science 2019-08-20 Marco Rudolph , Bastian Wandt , Bodo Rosenhahn

We propose a new concept of rateless auto-encoders (RL-AEs) that enable a flexible latent dimensionality, which can be seamlessly adjusted for varying distortion and dimensionality requirements. In the proposed RL-AEs, instead of a…

Machine Learning · Computer Science 2020-05-07 Toshiaki Koike-Akino , Ye Wang

Predicting the impact of genomic and drug perturbations in cellular function is crucial for understanding gene functions and drug effects, ultimately leading to improved therapies. To this end, Causal Representation Learning (CRL)…

Single-cell RNA sequencing (scRNA-seq) has revealed complex cellular heterogeneity, but recent studies emphasize that understanding biological function also requires modeling cell-cell communication (CCC), the signaling interactions…

Machine Learning · Computer Science 2025-12-29 Cong Qi , Yeqing Chen , Zhi Wei

Clustering using deep neural network models have been extensively studied in recent years. Among the most popular frameworks are the VAE and GAN frameworks, which learns latent feature representations of data through encoder / decoder…

Machine Learning · Computer Science 2021-05-14 Adam Lindhe , Carl Ringqvist , Henrik Hult

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

Machine Learning · Statistics 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak
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